DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15160 and Rprd2

DIOPT Version :9

Sequence 1:	NP_001286047.1	Gene:	CG15160 / 35109	FlyBaseID:	FBgn0032688	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001074762.1	Gene:	Rprd2 / 75137	MGIID:	1922387	Length:	1469	Species:	Mus musculus

Alignment Length:	1323	Identity:	267/1323 - (20%)
Similarity:	390/1323 - (29%)	Gaps:	566/1323 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EELFETRLEALKDTQEGIQQMSNWCLQHRSNHKKIIQCWLNVFKRVRVDHRLVLFYLANDVIQYS 71
            |...:.:.:::.:|.|.||.:|:||::::.:|..|:..|:...:|....|||.||||||||||..
Mouse    24 ESSLDRKFQSVTNTMESIQGLSSWCIENKKHHSTIVYHWMKWLRRSTYPHRLNLFYLANDVIQNC 88

  Fly    72 KRKR-YEFVECWATALQRATTMVRDERVKDKILRIFKIWEQREIYNEEYL--------------- 120
            |||. ..|.|.:|..|..|..:|:|..|...|.|||||||.|.:|.|:.:
Mouse    89 KRKNAIIFRESFADVLPEAAALVKDPSVSKSIERIFKIWEDRNVYPEDMIVALREALMDRAASHN 153

  Fly   121 -----------------SDLSGLLNIAPP---KKSQVDVSD----------EFQNATLIAQV--- 152
                             ..|...||..|.   ||||...:.          ||::..||.::
Mouse   154 ARLQKLQCFPGTTFKTQKQLKENLNKQPNKQWKKSQTSTNPKAALKSKIVAEFRSQALIEELLMY 218

  Fly   153 RECVELAEITDKSMQKLPKPPTFEIEVIKQQ----LKDKSHSGNIEKEVERCVAFINAYNKNLQN 213
            :...:..|:.:|.:.      |..::|...:    ||||:......||.|...:.:..:...|..
Mouse   219 KRSEDQIELKEKQLS------TMRVDVCSTETLKCLKDKTGGKKFSKEFEEASSKLEEFVNGLDK 277

  Fly   214 EIKSRKAVLASIEAAKKFYEHQGKEVKVVASAYKSFGTRIKIVKRKLDE---TIPN-LASPIPSP 274
            ::|:..::..::|.|..|||.|.|||||||:|||:|..|:..:|:|||:   |:|: ..||:|||
Mouse   278 QVKNGPSLTEALENAGIFYEAQYKEVKVVANAYKTFANRVNNLKKKLDQLKSTLPDPEESPVPSP 342

  Fly   275 DVNAPSP---------------------------------ERDAD-------------------- 286
            .::||||                                 .||.:
Mouse   343 SMDAPSPTGSESPFQGMGGEEPQSPAMESDKSATPEPVTDNRDVEDMELSDVEDDGSKIIVEDRK 407

  Fly   287 ------------------------------------------------------LQLPEENNIPL 297
                                                                  |.||...|:.|
Mouse   408 EKPVEKPAVSTGVPTKSTESVSKASPCAPPSVPTTAAPPLPKPLSTALLSPSPTLVLPNLANVDL 472

  Fly   298 NLFGGSINGFTSYLDGGKLPFDINDFKRDSKDRGSAIEVI--GSRSDDEAYVPS----ANFYK-- 354
            ......::..||.:..    ..::...|.|....::...:  |.::...|..||    ||...
Mouse   473 AKISSILSSLTSVMKN----TGVSSASRPSPGIPTSPSNLSSGLKTPAPATTPSHNPLANILSKV 533

  Fly   355 ---PEPISSA----DSSSIPGLGG-----SAVYTPDAPLFGSNSQDQYVPP-------------- 393
               ||.|.||    .:.|.|.|.|     .:|.....|.....||.....|
Mouse   534 EITPESILSALSKTQTQSAPALQGLSSLLQSVTANPVPASEVTSQSTTASPASTTGSAVKGRNLL 598

  Fly   394 -------PPSHLYGDNGN---------------------------GGSSGGPSDQYTPAPMPPP- 423
                   |.|..|..:.:                           ..||.|.:..:.|:|..||
Mouse   599 SSTQSFIPKSFNYSPSSSTSEVSSTSASKASVGQSPVLPSTTFKLPSSSLGFTGTHNPSPAAPPT 663

  Fly   424 ---------------------------------------------PLPPSLG---PSSGSADDF- 439
                                                         |:..|||   ||.|.|.||
Mouse   664 EVAVCQSSEVSKPKPESESTSPSLEMKIHNFLKGNPGFSGLNLNIPILSSLGSSAPSEGHASDFQ 728

  Fly   440 ---NSTWNMSMSWTP---------------------------LDSSLNSSGASSSSYANQSTPNS 474
               .||...|:..||                           |.|.:.|.|:|:.|    ||.:.
Mouse   729 RGPTSTSVDSIDGTPVRDERSGTPTQDEMMDKPTSSSVDTMSLLSKIISPGSSTPS----STRSP 789

  Fly   475 PPHFDRKASSTAAPIEY-NELLHTNPAALGA--------------------------------ED 506
            ||..|.     :.|.|. |.:....|..||:                                ||
Mouse   790 PPGRDE-----SYPQELPNSVSTYRPFGLGSDSPYKQPSGGVERPSSLMDSSQEKLFPDTSFQED 849

  Fly   507 VDHRTLQL---PPAFEFGAKLGLSKD------KSRQLVD----------IDHR------------ 540
            .|:|..:.   ||:    |.:.|.|.      ||.:|.|          .:||
Mouse   850 EDYRDFEYSGPPPS----AMMNLEKKPAKSILKSSKLSDATEYQPILSSYNHRAQEFGVKSAFPP 910

  Fly   541 ----------NLISLTGSPG------------GAEKDFTGGDVDYRIVPSPNDEGI-------MA 576
                      |...|:..||            |:|:..:....|....|..|..|:       :.
Mouse   911 SVRALLDSSENCDRLSSPPGLFGAFNIRGNEPGSERSPSPSKNDAFFTPDSNHSGLSQSTAGHLT 975

  Fly   577 PPGNNYAKSKTCSPLKSNASSSSESDRVDGATRYDPADMVIDMDMSDDD-------IDESLREPK 634
            .|...|..|....|.:|..||.|......|.......:.|:...:|...       :..:.|:|.
Mouse   976 LPQTQYPDSPHSVPHRSIFSSQSTLAAPAGHPPTSGVEKVLASTISTTSTIEFKNMLKNASRKPS 1040

  Fly   635 EDNGDAEIDANGALTPSRPVLLETPPDFINPWDANNSFMGPPLPDEEDQQQHH------------ 687
            :|....:....|  |.|..|.|             ::...|.||..:.||:.|
Mouse  1041 DDKHFGQTPNKG--TSSDGVSL-------------SNLTQPSLPTTDQQQEEHYRIETRVSSSCL 1090

  Fly   688 ------EQQQNQQQELQQHHQHQQHQQQQP-------------------------WNQMNR---- 717
                  |::....:.|..|:...:....:|                         |..::.
Mouse  1091 DLPDSTEEKGAPIETLGYHNAANRRMSGEPIKTVESIRVPGKGNRGHGREVSRVGWFDLSTPGSS 1155

  Fly   718 -----------MQMGGGGA---------PPPPRPPYGQ--------------------PFP---- 738
                       ..:||||:         |...|.|..|                    |.|
Mouse  1156 FDNGPSSASELASLGGGGSGGLTGFKTTPYKERAPQFQESVTSFRSNSFNSTFEHHLPPSPLEHG 1220

  Fly   739 -PFQRFPGPPMNGPDGMQRGRGRGRGWNGP---------------------GPGPFRPPYQRMPG 781
             ||||.|..|.:.|....:..|.......|                     ||.|  ||.:. .|
Mouse  1221 APFQREPVGPSSAPPAPPKDHGGIFSREAPTHLPSVDLSNPFTKEASLAHAGPPP--PPGEH-SG 1282

  Fly   782 PGFDGPGPGPRPFFPRGGGPGGP 804
            ..|..|.|.|.|.....||.|.|
Mouse  1283 VPFPPPPPPPPPGELSSGGTGVP 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15160	NP_001286047.1	RPR	10..128	CDD:214731	47/150 (31%)
Rprd2	NP_001074762.1	RPR	27..145	CDD:214731	46/117 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..445		13/115 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..524		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	572..594		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..686		6/38 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	716..867		35/163 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	919..1013		19/93 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1033..1140		18/121 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1154..1183		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1328		26/105 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1368..1414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833690
Domainoid	1	1.000	62	1.000	Domainoid score	I10343
eggNOG	1	0.900	-	-		E1_KOG2669
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3868
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1091009at2759
OrthoFinder	1	1.000	-	-		FOG0000693
OrthoInspector	1	1.000	-	-		oto94612
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12460
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1901
SonicParanoid	1	1.000	-	-		X4975
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890