DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15160 and rprd2a

DIOPT Version :9

Sequence 1:	NP_001286047.1	Gene:	CG15160 / 35109	FlyBaseID:	FBgn0032688	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_956216.1	Gene:	rprd2a / 334701	ZFINID:	ZDB-GENE-030131-6641	Length:	1113	Species:	Danio rerio

Alignment Length:	1132	Identity:	265/1132 - (23%)
Similarity:	391/1132 - (34%)	Gaps:	379/1132 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EELFETRLEALKDTQEGIQQMSNWCLQHRSNHKKIIQCWLNVFKRVRVDHRLVLFYLANDVIQYS 71
            |...:.|.:.:.:|.|.||.:|.||::::..|..|::.|:...::....|||.||||||||||..
Zfish    20 ESTLDRRFQTVSNTMESIQGLSTWCIENKKFHSVIVKYWIKWLRKSDASHRLNLFYLANDVIQNC 84

  Fly    72 KRK-----RYEFVECWATALQ--RATTMVRDERVKDKILRIFKIWEQREIYNEEYLSDL-SGLLN 128
            |||     |..|.:....|:.  |||   :|.:||..:.||..|||:|.:|:||::|.| :.|..
Zfish    85 KRKNAIVYRTTFTDLLPEAMHLIRAT---KDAKVKKSVERILSIWEERNVYSEEFISQLRNSLAR 146

  Fly   129 IAPPKKSQ-----------VDVSDEFQNATLI---AQVRECVELAEITDKSMQKLPKPPTFEIEV 179
            ...|.|.|           ..:..||..:|.|   ::.|:.::..|:.:|.:..: :......|.
Zfish   147 KEEPVKVQPAPVNSKSALKSKIVAEFVPSTFIEHLSKYRKSMDEIELKEKQLAAM-RVDVCSTEA 210

  Fly   180 IKQQLKDKSHSGNIEKEVERCVAFINAYNKNLQNEIKSRKAVLASIEAAKKFYEHQGKEVKVVAS 244
            :| :||||:......|:.|.....:..:...|..|:|...|::.::|.|..|||.|.||||:||.
Zfish   211 LK-KLKDKAGGKRFSKDFEDGSMKLQEFVSFLDGEVKKGPALMEALENADIFYEMQYKEVKIVAK 274

  Fly   245 AYKSFGTRIKIVKRKLD---ETIPNL-ASPIPSPDVNAPSP----------ER------DADLQL 289
            ||::|..|:..:|||||   ..||:. .||||||..:||||          ||      |.|.|.
Zfish   275 AYETFANRVSHLKRKLDAQKTMIPDPDDSPIPSPIEDAPSPTGSESPFHALERIGTPDPDLDGQA 339

  Fly   290 PEENNI-------PLNLFGGSINGFTSYLDGGKLPFDINDFKRDSKDRGSAIEVIGSRSDDEAYV 347
            .||:..       ||:..|||.....|.  |.|...|:.|.:....:......:|....:.:..|
Zfish   340 MEEDLFALADAPSPLSSSGGSPPPSVSM--GDKDNRDVEDMELSDAEETETPAIIVEECEAQTVV 402

  Fly   348 --------------PSANFYKPEPISS--------ADSSSIPGL--------GGSAVYTPDAPLF 382
                          |:....:.|.|::        |..||:..:        ..:|..||..|
Zfish   403 SKESPVTPNVTESLPTNEVTQTEKIATPPATAPQLAPQSSVTAVTTTTTTTTAAAATTTPTTP-- 465

  Fly   383 GSNSQDQYVPPPPSHLYGDNG--------------NGG------SSGGPSDQYTPAPM---PPPP 424
                ..|.:|..|:.:  |.|              |..      |...||...||..:   |..|
Zfish   466 ----TTQTLPVNPAGV--DLGKISSILSTLTNVMKNSAVGVSPVSRSSPSVPATPTSVQKTPTTP 524

  Fly   425 LPPSLGPSSG--SADDFNSTWNMS-MSWTP-------LDSSLNSSGASSSSYANQ-----STP-- 472
            .||: .|.:.  |..|.|:...:| :|.|.       |.|.||:..|.:.:.:|.     :||
Zfish   525 APPA-NPLTSILSRVDINTNTLLSALSKTQSLGGFHGLSSLLNNPAAKTPTNSNSEKQSLTTPVT 588

  Fly   473 ---NSPPHFDRKASSTAAPIEYNELLHTNPAALGAEDVDHRT-----------------LQLPPA 517
               ::||......:|.....:.....:..|:.|.:..|:.:.                 ||:.|.
Zfish   589 EESHTPPKVIPTPTSVPLTSDTTSQGYVAPSTLQSNVVNEKVNPNSSLNPTLDSKIDTFLQVHPG 653

  Fly   518 FEFGAKLGLSKDKSRQLVDIDHRNLISLTGSPGGAEKDFTGGDVDYRIVPSPNDEGIMAPPGNN- 581
            .: |:.||...........:|         ||..:.::..|..|......:|..:.||..|.:.
Zfish   654 LK-GSNLGFPSVLPWPKGTVD---------SPSASAENLGGTPVRDEAGATPTQDEIMDDPRSEP 708

  Fly   582 --YAKSKTCS-PLKSNASSSSESDRVDGATRYDP---------ADMVID---------------- 618
              |.:.:|.| ..||....||..|::..|....|         .|.|..
Zfish   709 FPYQQGQTASTDSKSTCQLSSWQDQIAHADAQAPEIHQTIASIKDSVPSLAEAEAQRHQRMEAMR 773

  Fly   619 ---MDMSDDDIDESLR-----------------------EPK--------EDNGDAEI----DAN 645
               |..:.....|||.                       .||        :|..:..:    |..
Zfish   774 SSLMSSNQQSSRESLEATERSSMLLQDMRQNPLIHNVAPNPKLAEGSYAYQDGQERHVLPNSDTY 838

  Fly   646 GA------------------LTPSRPVLLETPP--------------------DFINPW-DANNS 671
            |.                  .||..|:....||                    |...|: ||...
Zfish   839 GGDPYLSKDQRPNLTAPAFFTTPLPPIPKLPPPPKEFMAAASSLRANAPHTTRDLPGPFGDAERG 903

  Fly   672 FM-GPPLPDEEDQQQ-------------------------HHEQQQNQQQELQQHHQHQ-----Q 705
            .: |..:|.:.|.:|                         ||..:......:..:|||.     |
Zfish   904 GVDGSYIPAKSDYEQLSHEVPKEGPFHPHGDRIAHSAHAPHHASKIPPNGPMDYNHQHPPRAPLQ 968

  Fly   706 HQQQQPWNQMNRMQMGGGGAPP---------PPRP----PYGQPF---PPFQRFPGP-------- 746
            |....|.:.:       ||.||         ||||    ||...:   |  ||.|.|
Zfish   969 HPPSIPHHHI-------GGPPPVMSYHEAQSPPRPLPEDPYADTYYDHP--QRSPSPSHYDMHSV 1024

  Fly   747 -------------PMNGPDGMQRGRGRGRGWNGPGPGPFRPPYQRMPGPGFDGPG--PGPRPF-- 794
                         |...|..|:.        ..|.|...|||:          ||  |.|||.
Zfish  1025 SSHAQEYYPEGRAPPRAPPHMEH--------RPPPPHHVRPPH----------PGHYPPPRPIRR 1071

  Fly   795 ---------FPRGGGPGGPMRGRGRMR 812
                     ||||..||.|..|..|:|
Zfish  1072 PPPVHHEPPFPRGKRPGPPFGGPPRVR 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15160	NP_001286047.1	RPR	10..128	CDD:214731	48/125 (38%)
rprd2a	NP_956216.1	RPR	22..144	CDD:214731	47/124 (38%)
rprd2a	NP_956216.1	CREPT	196..321	CDD:293174	46/126 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576405
Domainoid	1	1.000	52	1.000	Domainoid score	I11452
eggNOG	1	0.900	-	-		E1_KOG2669
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3837
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1091009at2759
OrthoFinder	1	1.000	-	-		FOG0000693
OrthoInspector	1	1.000	-	-		otm24252
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12460
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4975
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.860