Protein Alignment Pde11 and PDE2

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_015005.1
• Gene: PDE2 / 854542
• SGDID: S000005887
• Length: 526
• Species: Saccharomyces cerevisiae
• Alignment Length: 563
• Identity: 116/563 - (20%)
• Similarity: 220/563 - (39%)
• Gaps: 142/563 - (25%)

  Fly   630 VHEADKGS--------FSRVFDFEAND-LSEEEATSRTSPYESRFPINIGITGHVATTGETVNVP 685
            :||.:|..        |.||.:.:..| |.......|.||    || |:    |...||.::.:
Yeast     9 IHEIEKSQTIVQNEHYFDRVIELQDLDSLMVALYKDRVSP----FP-NV----HNFETGVSIVL- 63

  Fly   686 NAYEDDRFDASVDE-NSCFKH------------------RSILCMAIKNSLGQIIGVIQLINKFN 731
              |:..:|..||.: :..||.                  :.:.|:..:||:.:     ..|.:.|
Yeast    64 --YDPSKFQLSVRQLDVLFKRFFPSFNISAIDHTREENLQRLECVERENSICR-----NRITRIN 121

  Fly   732 ELDFTKNDENFVEAFAIFCGMGIHNTHMY----EKAIVAMAKQSVTLEVLSYHASATMDEAHRLR 792
            ...:..:|:.         ..|| |.:.|    ..::...|.:: .:..|..|.:.:  :|..||
Yeast   122 HWMYHHHDDT---------PDGI-NKNSYGTVNGNSVPTQACEA-NIYTLLLHLNDS--KAQHLR 173

  Fly   793 RLRVPSAV-HFRLHDFKFDDIHFEDDD----------------TLKACLRMFLDLDFVERFHIDY 840
            :..||..: :.....|..|.|.....:                :|.....::.....:::...|.
Yeast   174 KASVPRLIRNIEFMSFLSDPIEKISQEGSHYWNILSTWDFCALSLSTQELIWCGFTLIKKLSKDA 238

  Fly   841 EVLCR------WLLSVKKNYRNVT-YHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCL 898
            :||..      .|.:::.:|..|. :||:|||.:|.|..:.:.|   :......::.|.|.:..:
Yeast   239 KVLIADNKLLLLLFTLESSYHQVNKFHNFRHAIDVMQATWRLCT---YLLKDNPVQTLLLCMAAI 300

  Fly   899 CHDLDHRGTNNSFQIKASSPLAQLY-STSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRV 962
            .||:.|.||||.......|.:||.: :.|.:|:.|.:....:|:....|:| ::|...:    ..
Yeast   301 GHDVGHPGTNNQLLCNCESEVAQNFKNVSILENFHRELFQQLLSEHWPQLL-SISKKKF----DF 360

  Fly   963 LEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEPRALLRAMSMTV--CDLSAITKPWEIEKRV 1025
            :.:|||:||:|::           ||.....:.|.|...:..:|:.:  .|:|.:|:...|..|.
Yeast   361 ISEAILATDMALH-----------SQYEDRLMHENPMKQITLISLIIKAADISNVTRTLSISARW 414

  Fly  1026 ADLVSSEF-----------------------FEQGDMEKQEL--------NIT-PIDIMNREKED 1058
            |.|::.||                       ::..|..|::|        |:| |.||:  :...
Yeast   415 AYLITLEFNDCALLETFHKAHRPEQDCFGDSYKNVDSPKEDLESIQNILVNVTDPDDII--KDHP 477

  Fly  1059 ELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWI 1101
            .:|..|:.||::.....:.|.:.....|:.|.:.|:.|:.:|:
Yeast   478 HIPNGQIFFINTFAEVFFNALSQKFSGLKFLSDNVKINKEYWM 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	33/163 (20%)
		PDEase_I	859..1093	CDD:459723	62/268 (23%)
PDE2	NP_015005.1	PDEase_I	264..512	CDD:459723	62/268 (23%)