DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde11 and Pde1c

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_112340.1	Gene:	Pde1c / 81742	RGDID:	68332	Length:	768	Species:	Rattus norvegicus

Alignment Length:	729	Identity:	174/729 - (23%)
Similarity:	283/729 - (38%)	Gaps:	141/729 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   629 LVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRF 693
            ||.:.::|..| |.|.:.|  .|..||...|.|             :..|...::..:...|.:.
  Rat   107 LVKQLERGEAS-VVDLKKN--LEYAATVLESVY-------------IDETRRLLDTEDELSDIQS 155

  Fly   694 DASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTH 758
            ||...|     .|..|.......:|      .::.:.:|....|:..:.|:|       ||....
  Rat   156 DAVPSE-----VRDWLASTFTRQMG------MMLRRSDEKPRFKSIVHAVQA-------GIFVER 202

  Fly   759 MYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHD---FKFDDIHFED---D 817
            ||        :::..:..|||                 |.||...|.|   :.||.....:   |
  Rat   203 MY--------RRTSNMVGLSY-----------------PPAVIDALKDVDTWSFDVFSLNEASGD 242

  Fly   818 DTLKACLRMFLDL----DFVERFHIDYEVLCRWLLSVKKNY---RNVTYHNWRHAFNVAQMMFAI 875
            ..||.   :|.:|    |.:.||.|....|..::.:::..|   :| .|||..||.:|.|.:..:
  Rat   243 HALKF---IFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKN-PYHNLMHAADVTQTVHYL 303

  Fly   876 LTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMI 939
            |..|.......|:|..|:|.....||.:|.||.|:|.|:..|..|.||: .|.:|:||......:
  Rat   304 LYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRL 368

  Fly   940 LNSPGN-QILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEPRALLR 1003
            |..... .||.|||.||:.....::.:.:::||::.:|::......::.||.:   .|:|:||
  Rat   369 LQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA---IEKPKAL-- 428

  Fly  1004 AMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFI 1068
            ::.:...|:|...|.|::..|....:..|||.|||.| .||.: |...:...|...:...||.||
  Rat   429 SLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDRE-AELGL-PFSPLCDRKSTMVAQSQVGFI 491

  Fly  1069 DSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCK 1133
            |.|..|   .|..|:|..|.:|..:.|              :|||.....:.:...|.|::.|.|
  Rat   492 DFIVEP---TFTVLTDMTEKIVSPLID--------------ETSQTGGTGQRRSSLNSINSSDAK 539

  Fly  1134 ------AMSDDDVAASEAEVAVDSPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQPSDDDNDV 1192
                  :.|:.....:.:.:.||..|.||:.. ..|..|......|:          |.::  ..
  Rat   540 RSGVKSSGSEGSAPINNSVIPVDYKSFKATWT-EVVQINRERWRAKV----------PKEE--KA 591

  Fly  1193 DADADDVDEQAAEENGHDAEVDEASCRSNSTCSSSTASSCLSTPPPTGEDDSTPVSPLKTLQAKL 1257
            ..:|::....||||.  ..|::..|.....|.|.:...:...|   .|:.:.|..|.....:.|.
  Rat   592 KKEAEEKARLAAEEK--QKEMEAKSQAEQGTTSKAEKKTSGET---KGQVNGTRTSKGDNPRGKN 651

  Fly  1258 VAANLNALQRQTSNQAQTQKQRCKSCDHSRSGLQVRKTSSLRGAQELDLDSKTRNGTHAALCKST 1322
            ...: .|.::|.:...:..|.:....|||.:|.:.:|.         |...|..:|:.|....||
  Rat   652 SKGD-KAGEKQQNGDLKDGKNKADKKDHSNTGNESKKA---------DGTKKRSHGSPAPSTSST 706

  Fly  1323 -----PVINNHSHH 1331
                 |||.....|
  Rat   707 SRLTLPVIKPPLRH 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	28/132 (21%)
		PDEase_I	859..1094	CDD:278654	74/236 (31%)
Pde1c	NP_112340.1	PDEase_I_N	146..202	CDD:285672	13/73 (18%)
		PDEase_I	287..515	CDD:278654	74/237 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..557		9/57 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..719		33/161 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347770
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940