Protein Alignment Pde11 and pde4b

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_031756141.1
• Gene: pde4b / 780324
• XenbaseID: XB-GENE-963512
• Length: 733
• Species: Xenopus tropicalis
• Alignment Length: 636
• Identity: 143/636 - (22%)
• Similarity: 257/636 - (40%)
• Gaps: 142/636 - (22%)

  Fly   594 LARMIFEEQS-------TIEHMVFRILTHMQSLIQCQRVQIL-LVHEADKGSFSRVFDFEANDLS 650
            ::|:..:|.|       |:|.:.:       .|.|.:.:|.. .|.|.....|.|:.:.|...||
 Frog   203 ISRVNLQEDSYQKIAMDTLEELDW-------CLDQLETIQTYRSVSEMASNKFKRMLNRELTHLS 260

  Fly   651 EEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKN 715
            |   .||:....|.:     |:.........|.:|:..:.||      |..  |.:.::.
 Frog   261 E---MSRSGNQVSEY-----ISSTFLDKQNDVEIPSPTQKDR------EKK--KKQQLMT----- 304

  Fly   716 SLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTL-EVLSY 779
               ||.||.:|::. :.|:.|.     :..|    |:......|..|.:..:.|..:.: :|.||
 Frog   305 ---QISGVKKLMHS-SSLNNTS-----MSRF----GVKTEYEDMLSKELEDLNKWGLNIFKVASY 356

  Fly   780 HASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACL--RMFLDLDFVERFHIDYEV 842
            ..:..:                                    .|:  .:|.:.|.::.|.|..:.
 Frog   357 SCNRPL------------------------------------TCIMYAIFQERDLLKTFKIPADT 385

  Fly   843 LCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRG 906
            |..:.::::.:|. :|.|||..||.:|.|....:|:|.....:|.::|.||.|.....||:||.|
 Frog   386 LITYTMTLEDHYHSDVAYHNSLHAADVTQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPG 450

  Fly   907 TNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILST 970
            .:|.|.|..:|.||.:|: .|.:|:||......:|......|..||:......:.:::.|.:|:|
 Frog   451 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKKQRQSLRKMVIDMVLAT 515

  Fly   971 DLAVYFKKRGPF--LESVSQPTSYWVA-----EEPRALLRAMSMTVC-DLSAITKPWEIEKRVAD 1027
            |::.:.......  :....:.||..|.     .:...:||  :|..| |||..||..|:.::..|
 Frog   516 DMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLR--NMVHCADLSNPTKSLELYRQWTD 578

  Fly  1028 LVSSEFFEQGDMEKQE-LNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEP--- 1088
            .:..|||:|||.|::. :.|:|   |..:....:...||.|||.|..|::|.:|   |.::|
 Frog   579 RIMEEFFQQGDKERERGMEISP---MCDKHTASVEKSQVGFIDYIVHPLWETWA---DLVQPDAQ 637

  Fly  1089 -LVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCKAMSDD---DVAASEAEVAV 1149
             :::.:.||| :|      .::...|...|..::..:      ||:.:|:.   ::...|.:
 Frog   638 DILDTLEDNR-NW------YQSMIPQSPSPLLDEHDK------DCQGLSEKFHFELTLEEED--- 686

  Fly  1150 DSPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQPSDDDNDVDAD--ADD 1198
               |:....:|..::..||.....|.       .|..:|..|.|.:  .||
 Frog   687 ---SDGHDKDGDCLSFYSSTKTLHIV-------DQGMEDSPDADTEFLTDD 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	31/151 (21%)
		PDEase_I	859..1093	CDD:459723	73/247 (30%)
pde4b	XP_031756141.1	PDE4_UCR	164..279	CDD:465648	20/90 (22%)
		PDEase_I	403..643	CDD:459723	73/247 (30%)