Protein Alignment Pde11 and pde5a

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_012821480.2
• Gene: pde5a / 780273
• XenbaseID: XB-GENE-479676
• Length: 943
• Species: Xenopus tropicalis
• Alignment Length: 946
• Identity: 417/946 - (44%)
• Similarity: 549/946 - (58%)
• Gaps: 146/946 - (15%)

  Fly   220 RQTVDAWLVS--HATSAGNDVVSSTSPTHANGQTSSSRGGSGATTPVRKISAHEFERGGLLKPIV 282
            ::.|:||...  |...|..:...:.|  .:|.|...|...:.. ||||||||.||:|.  |:|||
 Frog   121 QEMVNAWFAERVHTIPASKEQGKNNS--ESNPQVCYSENTTQG-TPVRKISASEFDRP--LRPIV 180

  Fly   283 --NTIDGTPTFLSIGPPMDNGSVGGSCSNLQNVGGVVAGQYQYNHQQHHHNHAHLHHSQHSHYQA 345
              ::: ||..|||       .|.......||
 Frog   181 VKDSV-GTLKFLS-------DSEKKELMPLQ---------------------------------- 203

  Fly   346 GGAVGSSSLGSTGGASGAGGAPSLGGSGGAGNGHQYPYYHCHQRPQRLSRNELKQLDEKELIFEL 410
                                .|||..:|                            |:...:.||
 Frog   204 --------------------PPSLSRAG----------------------------DQCSRLLEL 220

  Fly   411 VKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKKCLVSKLFDVCPRSTVEEM 475
            ||||.:.|:|.||||||..::..|:.|||.|||||   |..... ||.|||:||||...:|||:
 Frog   221 VKDISSHLDVTTLCHKIFLHIHELIAADRYSLFLV---CEDSSN-KKFLVSRLFDVAEGTTVEQ- 280

  Fly   476 EQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIG 540
            ...:.:|:.|..||.|||||.|:|:||.|||||.|||.|:|.:|||:|:::||||||:...:|:|
 Frog   281 ASNNCIRLEWNKGIVGHVAEFGQPLNIKDAYQDSRFNAEVDQITGYKTQSILCMPIKNHREEVVG 345

  Fly   541 VAQVINKMNGE--CFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQS 603
            |||.|||.:|.  .|::.|||.|::||.||||.|.||||||.|.||.:|||||||||.:|||||.
 Frog   346 VAQAINKKSGSNGTFTDQDEKDFAAYLAFCGIVLHNAQLYETSLLENRRNQVLLDLATLIFEEQQ 410

  Fly   604 TIEHMVFRILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPIN 668
            ::|.::.:|...:.|.:|.||..|.:|.|....:||.||..|:::| ||.|.:....|:.. .:|
 Frog   411 SLEVILKKIAATILSFMQAQRCTIFIVDEDSPDTFSSVFHMESDEL-EESADAVKREYDVS-KMN 473

  Fly   669 IGITGHVATTGETVNVPNAYEDDRFD-ASVDENSCFKH-RSILCMAIKNS-LGQIIGVIQLINKF 730
            .....:||.|.|.:|:|:..:|.||. .:.:|...||| :|:||..|||: ..::|||.||:||.
 Frog   474 YMYAQYVANTMEAINIPDICKDTRFPWTNGNEEKNFKHIQSLLCSPIKNAKKNKVIGVCQLVNKV 538

  Fly   731 NELD-----FTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHR 790
            :|..     |.||||.|:||||||||:||.||.|:|....|||||.||||:|||||||..:|...
 Frog   539 DENSGKIKAFNKNDEQFLEAFAIFCGLGIQNTQMFEVVERAMAKQMVTLEILSYHASAAEEETME 603

  Fly   791 LRRLR---VPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKK 852
            |:...   ||||...:|.:|.|.|....|.:|..|..|||.||:.|:.|.:.||.||||:|||||
 Frog   604 LQVTAGAIVPSAQSLKLTEFYFSDFELSDMETTLATSRMFTDLNLVQTFQMKYETLCRWILSVKK 668

  Fly   853 NYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKAS 916
            ||| ||.|||||||||.||.|||.|.|.:......::|.|||:|..|.|||||||.||||..::.
 Frog   669 NYRKNVAYHNWRHAFNTAQCMFAALRTGKIQGKLNDLEILALMIATLSHDLDHRGVNNSFIQRSE 733

  Fly   917 SPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGP 981
            .||||||..|.||:||||||||||||.|||||:.||..||..|:::::.|||:||||:|.|:|..
 Frog   734 HPLAQLYCHSIMENHHFDQCLMILNSQGNQILSGLSVQDYKTVLKMIKQAILATDLALYIKRRSD 798

  Fly   982 FLESVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNI 1046
            |.|.|::....|.....:.|..||.||.||||||||||.:::|:|:||:|||::|||.|::||||
 Frog   799 FFELVNKKKFKWDDPSQKELFLAMLMTACDLSAITKPWPVQQRIAELVASEFYDQGDKERRELNI 863

  Fly  1047 TPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKT 1111
            .|||:|||||:|::|.|||.|||::||.:|||...:|:...||::|.:.||..|..||
 Frog   864 EPIDLMNREKKDKIPSMQVGFIDAVCLELYEALTQISESCYPLLDGCQRNRQMWQILA------- 921

  Fly  1112 SQDQEPEEEQQQQNVISNGDCKAMSDDDVAASEAEV 1147
                    |||::|:: ||          |.|:.||
 Frog   922 --------EQQEKNLV-NG----------AKSQPEV 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	89/163 (55%)
		GAF	611..762	CDD:214500	65/158 (41%)
		PDEase_I	859..1094	CDD:278654	133/234 (57%)
pde5a	XP_012821480.2	GAF	229..386	CDD:214500	87/161 (54%)
		GAF	412..577	CDD:214500	67/166 (40%)
		PDEase_I	676..911	CDD:395177	133/234 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4740
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H842
Inparanoid	1	1.050	712	1.000	Inparanoid score	I633
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	1	1.000	-	-		FOG0002593
OrthoInspector	1	1.000	-	-		otm48017
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5988
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970