DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and pde2a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_031751996.1	Gene:	pde2a / 780063	XenbaseID:	XB-GENE-5945995	Length:	964	Species:	Xenopus tropicalis

Alignment Length:	739	Identity:	230/739 - (31%)
Similarity:	368/739 - (49%)	Gaps:	70/739 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 YYHCHQRPQRLSRNELKQLDEKELIFELVKDICNE---LEVRTLCHKILQNVS----------IL 434
            |.:...:|...:.....:||.|      :..:|.|   |:..:|..|::..:.          :|
Frog   222 YQNSLPKPSPTANESYDELDRK------ILQLCGELYDLDAASLQIKVIHYLEQQTQSPCCCLLL 280

  Fly   435 LNADRGSLFLVQGRCNGPDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEP 499
            ::.|...||     |....|  |.|                  ::|:......|..|.|.:..:.
Frog   281 VSEDSHQLF-----CQVVGG--KVL------------------EEEISFPLTFGHLGQVVDKKKS 320

  Fly   500 VNIPDAYQDERFNCEIDSLTGYRTKALLCMP-IKDSSGDVIGVAQVINKMNGECFSEIDEKVFSS 563
            :.:.|...:|  :.:::::.|:...::||:| |..::..|:.:|...||..|: ::|:||.....
Frog   321 ITLQDISSEE--HRQLNNMLGFEVHSMLCVPVISRATSQVVALACAFNKQGGK-YTEVDEHKIQH 382

  Fly   564 YLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQIL 628
            ...:....|.:...::|.|......|.||.:|:.:|.....:..::..|:|..::|...:...:.
Frog   383 CFCYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVF 447

  Fly   629 LVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRF 693
            |:........::|||   ..:.::|:      ||.|.|.:.||.|||||||:.:|:.:||....|
Frog   448 LLERQSHELVAKVFD---GGVVDDES------YEIRIPADQGIAGHVATTGQILNIKDAYSHPLF 503

  Fly   694 DASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTH 758
            ...||:::.|:.|:|||..|||...::|||.:|:||.|...|||.||:...||:|:||:.|.::.
Frog   504 YRGVDDSTGFRTRNILCFPIKNESNEVIGVAELVNKINGPGFTKFDEDLATAFSIYCGISIAHSL 568

  Fly   759 MYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHF--RLHDFKFDDIHFEDDDTLK 821
            :|::...|..:..:..|::.||.....||..:|:...:.|....  ....|.:......:|||:.
Frog   569 LYKQVREAQFRSHLANEMMMYHMKVCEDETKKLQSNGIVSVCQIDPGFASFSYTPRSLPEDDTVM 633

  Fly   822 ACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFG 886
            ..:.||.|:.||..:.||...|.|:.|.|||.||:..||||.|||:|:...:.:....:......
Frog   634 CVISMFEDMGFVNNYKIDRTTLIRFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLFKNLELVNYLE 698

  Fly   887 EIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYST--STMEHHHFDQCLMILNSPGNQILA 949
            .||..||.:.||||||||||||||||:.:.|.||.|||:  |.||.|||.|.:.||||.|..||.
Frog   699 YIEIFALFVSCLCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNSQGCNILE 763

  Fly   950 NLSSDDYCRVIRVLEDAILSTDLAVY---FKKRGPFLESVSQPTSYWVAEEPRALLRAMSMTVCD 1011
            ..|..||.|::.::.|.||:||||.:   ||:    |..:||.......:....||..:.||..|
Frog   764 QFSRKDYQRMLDLMRDIILATDLAHHLRIFKE----LTRMSQDGFDPQNKHHHYLLICLLMTSSD 824

  Fly  1012 LSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIY 1076
            ||..||.|:..:::|:|:..|||.|||:||...| .|.::|:|||. .:|.:|::|::.|.:|||
Frog   825 LSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGN-RPSEMMDREKA-YIPELQISFMEHIAMPIY 887

  Fly  1077 EAFATLSDKLEPLVEGVRDNRGHW 1100
            .....|..:...|.|.|..||..|
Frog   888 NLLKDLFPRSAELYERVATNREKW 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	31/172 (18%)
		GAF	611..762	CDD:214500	54/150 (36%)
		PDEase_I	859..1094	CDD:278654	100/239 (42%)
pde2a	XP_031751996.1	GAF	255..401	CDD:214500	31/173 (18%)
		GAF	423..574	CDD:214500	54/159 (34%)
		PDEase_I	671..904	CDD:395177	100/238 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I6990
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010