DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and Pde10a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_038945075.1	Gene:	Pde10a / 63885	RGDID:	68434	Length:	1075	Species:	Rattus norvegicus

Alignment Length:	855	Identity:	270/855 - (31%)
Similarity:	410/855 - (47%)	Gaps:	142/855 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   347 GAVGSSSLGSTGGASGAGGAPSLGGSGGAG-------NGHQYPY-------------------YH 385
            ||..:.|||..|   ..||.|.||....||       .|...|.                   ..
  Rat   230 GAHRADSLGFPG---AGGGCPGLGPGSAAGGRTPWRPRGTALPLATAWPLLFGSDMEDGPSNNAS 291

  Fly   386 CHQR----------------------PQ-----------------RLSRNELKQLDE---KE--- 405
            |.:|                      ||                 .|.|...|..||   ||
  Rat   292 CFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKAEDEPSPKEVSR 356

  Fly   406 --------LIFELVKDICNELEVRTLCHKILQNVS----ILLNADRGSLFLVQGRCNG------P 452
                    :::||...|...|:.....|.:|..:|    |...||..:|:.: |.||.      |
  Rat   357 YQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFL-GECNNSLCVFTP 420

  Fly   453 DGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDS 517
            .|:|:. ..:|....|              :..||.|:.:||:|.:.:.:.|...||||......
  Rat   421 PGMKEG-QPRLIPAGP--------------ITQGTTISAYVAKSRKTLLVEDILGDERFPRGTGL 470

  Fly   518 LTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQ 582
            .:|.|.:::||:||..:.||:||:.::......|.|....::|.::.|.:..:.:...|:.....
  Rat   471 ESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLA 535

  Fly   583 LEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFEAN 647
            .:.:.|..|||:::..|:....|:.::..|:.:.::|:...|..:..|...:|..:|.:|
  Rat   536 KQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLF----- 595

  Fly   648 DLSEEE----ATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDENSCFKHRSI 708
            |:.||:    ...:|.  |.||.|..||.|.||.|||.:|:|:||.|.||:..||..:.:..|:|
  Rat   596 DIGEEKEGKPVFKKTK--EIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNI 658

  Fly   709 LCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVT 773
            |||.|. |.|.:|||:|::||.:...|:|.|||..:.||:||.:.:|..:||.:...:.....||
  Rat   659 LCMPIV-SRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVT 722

  Fly   774 LEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFH- 837
            :|.||||:..|.:|...|....:|:.:...:..|.||...||:         |:..: ||...|
  Rat   723 MEKLSYHSICTSEEWQGLMHFNLPARICRDIELFHFDIGPFEN---------MWPGI-FVYMIHR 777

  Fly   838 ------IDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIG 896
                  .:.|.|||:::|||||||.|.||||:||..||..|:|||....  .:|.::|...|:|.
  Rat   778 SCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNN--GLFTDLERKGLLIA 840

  Fly   897 CLCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIR 961
            ||||||||||.:||:..|...|||.||||||||.|||.|.:.||...|:.|.:.|||.:|.:|:.
  Rat   841 CLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 905

  Fly   962 VLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEP-RALLRAMSMTVCDLSAITKPWEIEKRV 1025
            ::..||::||||:||..|.. ||.:.|..|..:..:. |..:..:.||.|||.::||.|.:.|..
  Rat   906 IIRKAIIATDLALYFGNRKQ-LEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLWPVTKLT 969

  Fly  1026 ADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLV 1090
            |:.:.:||:.:|| |.::|.|.||.:|:|:|.||:|..|:.|.:::.:|.|.....:....|||:
  Rat   970 ANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 1033

  Fly  1091 EGVRDNRGHW 1100
            :..|||...|
  Rat  1034 KACRDNLNQW 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	41/171 (24%)
		GAF	611..762	CDD:214500	58/154 (38%)
		PDEase_I	859..1094	CDD:278654	99/235 (42%)
Pde10a	XP_038945075.1	GAF	382..525	CDD:396252	40/158 (25%)
		GAF	558..713	CDD:214500	59/162 (36%)
		PDEase_I	805..1037	CDD:395177	99/235 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920