Protein Alignment Pde11 and Pde10a

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_038945075.1
• Gene: Pde10a / 63885
• RGDID: 68434
• Length: 1075
• Species: Rattus norvegicus
• Alignment Length: 857
• Identity: 270/857 - (31%)
• Similarity: 409/857 - (47%)
• Gaps: 146/857 - (17%)

  Fly   347 GAVGSSSLGSTGGASGAGGAPSLGGSGGAG-------NGHQYP---------------------- 382
            ||..:.|||..|   ..||.|.||....||       .|...|
  Rat   230 GAHRADSLGFPG---AGGGCPGLGPGSAAGGRTPWRPRGTALPLATAWPLLFGSDMEDGPSNNAS 291

  Fly   383 ---------------------YYHCHQRPQ-----------------RLSRNELKQLDE---KE- 405
                                 |...|  ||                 .|.|...|..||   ||
  Rat   292 CFRRLTECFLSPSLTDEKVKAYLSLH--PQVLDEFVSESVSAETVEKWLKRKNNKAEDEPSPKEV 354

  Fly   406 ----------LIFELVKDICNELEVRTLCHKILQNVS----ILLNADRGSLFLVQGRCNG----- 451
                      :::||...|...|:.....|.:|..:|    |...||..:|:.: |.||.
  Rat   355 SRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFL-GECNNSLCVF 418

  Fly   452 -PDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEI 515
             |.|:|:. ..:|....|              :..||.|:.:||:|.:.:.:.|...||||....
  Rat   419 TPPGMKEG-QPRLIPAGP--------------ITQGTTISAYVAKSRKTLLVEDILGDERFPRGT 468

  Fly   516 DSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEK 580
            ...:|.|.:::||:||..:.||:||:.::......|.|....::|.::.|.:..:.:...|:...
  Rat   469 GLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRG 533

  Fly   581 SQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFE 645
            ...:.:.|..|||:::..|:....|:.::..|:.:.::|:...|..:..|...:|..:|.:|
  Rat   534 LAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLF--- 595

  Fly   646 ANDLSEEE----ATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDENSCFKHR 706
              |:.||:    ...:|.  |.||.|..||.|.||.|||.:|:|:||.|.||:..||..:.:..|
  Rat   596 --DIGEEKEGKPVFKKTK--EIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTR 656

  Fly   707 SILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQS 771
            :||||.|. |.|.:|||:|::||.:...|:|.|||..:.||:||.:.:|..:||.:...:.....
  Rat   657 NILCMPIV-SRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYR 720

  Fly   772 VTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERF 836
            ||:|.||||:..|.:|...|....:|:.:...:..|.||...||:         |:..: ||...
  Rat   721 VTMEKLSYHSICTSEEWQGLMHFNLPARICRDIELFHFDIGPFEN---------MWPGI-FVYMI 775

  Fly   837 H-------IDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALI 894
            |       .:.|.|||:::|||||||.|.||||:||..||..|:|||....  .:|.::|...|:
  Rat   776 HRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNN--GLFTDLERKGLL 838

  Fly   895 IGCLCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRV 959
            |.||||||||||.:||:..|...|||.||||||||.|||.|.:.||...|:.|.:.|||.:|.:|
  Rat   839 IACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQV 903

  Fly   960 IRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEP-RALLRAMSMTVCDLSAITKPWEIEK 1023
            :.::..||::||||:||..|.. ||.:.|..|..:..:. |..:..:.||.|||.::||.|.:.|
  Rat   904 LEIIRKAIIATDLALYFGNRKQ-LEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLWPVTK 967

  Fly  1024 RVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEP 1088
            ..|:.:.:||:.:|| |.::|.|.||.:|:|:|.||:|..|:.|.:::.:|.|.....:....||
  Rat   968 LTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQILPPTEP 1031

  Fly  1089 LVEGVRDNRGHW 1100
            |::..|||...|
  Rat  1032 LLKACRDNLNQW 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	41/171 (24%)
		GAF	611..762	CDD:214500	58/154 (38%)
		PDEase_I	859..1093	CDD:459723	99/234 (42%)
Pde10a	XP_038945075.1	GAF	<356..>540	CDD:441805	45/199 (23%)
		GAF	558..713	CDD:214500	59/162 (36%)
		PDEase_I	805..1036	CDD:459723	99/234 (42%)