Protein Alignment Pde11 and pde4a

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_009298019.1
• Gene: pde4a / 572061
• ZFINID: ZDB-GENE-131125-7
• Length: 777
• Species: Danio rerio
• Alignment Length: 646
• Identity: 143/646 - (22%)
• Similarity: 239/646 - (36%)
• Gaps: 166/646 - (25%)

  Fly   594 LARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFEANDLSEEEATSRT 658
            |||...||.......:..|.||..            |.|.....|.|:.:.|.:.|||   .||:
Zfish   221 LARETLEELDWCLDQLETIQTHRS------------VSEMASNKFKRMLNRELSHLSE---MSRS 270

  Fly   659 SPYESRFPINIGITGHVATT----GETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQ 719
            ....|.:         ::||    ...|.:|:....:|                     :..:..
Zfish   271 GNQVSEY---------ISTTFLDKQNEVEIPSPTLRER---------------------EKPMSH 305

  Fly   720 IIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASAT 784
            |.||.:|                              ||          ..|:|...|......|
Zfish   306 ISGVKKL------------------------------TH----------SSSLTSAALPRFGVKT 330

  Fly   785 MDEAHRLRRLRVPSAVHFRLHDFK------FDDIHFEDDDTLKACL--RMFLDLDFVERFHIDYE 841
            ..|          .|:...|:|..      |....|.::..| :|:  .:|.:.|.::.|.|..:
Zfish   331 EQE----------DALARELNDLNKWGLNIFHVAEFSNNRPL-SCIMFAIFQERDLLKTFRIPVD 384

  Fly   842 VLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHR 905
            ....::::::.:|. ||.|||..||.:|.|....:|:|.....:|.::|.||.:.....||:||.
Zfish   385 TFITYVMTLEDHYHANVAYHNSLHAADVTQSTHVLLSTPALDAVFSDLEILAALFAAAIHDVDHP 449

  Fly   906 GTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILS 969
            |.:|.|.|..:|.||.:|: .|.:|:||......:|:.....|..||:......:.:::.|.:|:
Zfish   450 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLHEENCDIFQNLTKRQRQSLRKLVIDMVLA 514

  Fly   970 TDLAVYFKKRGPF--LESVSQPTSYWVA-----EEPRALLRAMSMTVC-DLSAITKPWEIEKRVA 1026
            ||::.:.......  :....:.||..|.     .:...:||  :|..| |||..|||..:.::..
Zfish   515 TDMSKHMSLLADLKTMVETKKVTSSGVLMLDHYNDRIQVLR--NMVHCADLSNPTKPLAVYRQWT 577

  Fly  1027 DLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEP-- 1088
            :.:..|||:|||.|::. :.|:|   |..:....:...||.|||.|..|::|   |..|.:.|
Zfish   578 ERIMEEFFQQGDKERERGMEISP---MCDKHTASVEKSQVGFIDYIVHPLWE---TWGDLVHPDA 636

  Fly  1089 --LVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDS 1151
              :::.:.|||       |..::...|...|..::....:.|   |:.....::.. |.|...|.
Zfish   637 QEILDTLEDNR-------DWYQSTIPQSPSPPPDRPDNELES---CRNKFQFELTL-EGETVQDG 690

  Fly  1152 PSEKASVNGSNVANNSSNTNKKIAVASHPTSTQPSDDDNDVDADADDVDEQAAEENGHDAE 1212
            |                        .||........|:...|.:|::.:|..|||...|.|
Zfish   691 P------------------------PSHNHIVIHDQDEKKDDEEAEEAEEDEAEEKMEDGE 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	25/154 (16%)
		PDEase_I	859..1094	CDD:278654	71/248 (29%)
pde4a	XP_009298019.1	PDEase_I	403..644	CDD:278654	71/248 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589311
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750