DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and pde9ab

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_700447.5	Gene:	pde9ab / 571737	ZFINID:	ZDB-GENE-210629-1	Length:	518	Species:	Danio rerio

Alignment Length:	326	Identity:	105/326 - (32%)
Similarity:	175/326 - (53%)	Gaps:	31/326 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   809 FDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMF 873
            ||..|:|.::.|.....|:.||..|:.|:::...|.||||::::|||:..:||:||.|.|:|||:
Zfish   201 FDVWHWEHNEMLSCLEYMYHDLGLVKEFNMNPITLKRWLLAIQENYRDNPFHNFRHCFCVSQMMY 265

  Fly   874 AI---------LTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTM 928
            .:         ||.|..        |: |:...:||||||.|.||::||.|.:.||..|: .|.:
Zfish   266 GMIHLCGLQDRLTMTDM--------CI-LMTAAVCHDLDHPGYNNTYQINARTELAVRYNDISPL 321

  Fly   929 EHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYW 993
            |:||......||:.|...|.||:..:.:.::.:.:...||:||:|    |.|..|:|..|....:
Zfish   322 ENHHCAVAFQILSMPECNIFANIEPESFKQIRQAIITLILATDMA----KHGEILDSFKQKVDNF 382

  Fly   994 --VAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNRE 1055
              ..||....|:.:.:..||:|...:|.|:.:...|.:..|:|.|.|.||.| |.:.|  .|:|:
Zfish   383 DCTNEEHVKSLKMVLIKCCDISNEVRPTEVAEPWVDCLLEEYFMQSDREKSEGLPVAP--FMDRD 445

  Fly  1056 KEDELPMMQVNFIDSICLPIYEAFATLSDKLEP-LVEGVRDNRGHWIDLADVVKTKTSQDQEPEE 1119
            |..: |..|:.||..:.:|::|....|..::|. :|:.:||:|.|:.:|.. ::...|:.|:.:.
Zfish   446 KVTK-PTAQIGFIKFVLIPMFETVMKLFPQIEEIMVQPLRDSRDHYEELKQ-IEDAMSEAQKKKT 508

  Fly  1120 E 1120
            |
Zfish   509 E 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500
		PDEase_I	859..1094	CDD:278654	79/248 (32%)
pde9ab	XP_700447.5	PDEase_I	251..481	CDD:278654	78/245 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920