DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde11 and pde8b

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_009293455.1	Gene:	pde8b / 571011	ZFINID:	ZDB-GENE-091117-3	Length:	874	Species:	Danio rerio

Alignment Length:	875	Identity:	160/875 - (18%)
Similarity:	307/875 - (35%)	Gaps:	252/875 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   414 ICNELEVRTLC------------------HKILQNVSILLNADRGS----------LFLVQGRCN 450
            :|.|.|.:|.|                  |:.:|.:.:....|..|          .|    |||
Zfish    80 MCTEAETQTSCTSVKVSGAEDRLGPMRLSHEPIQVLLVFAKEDSQSDAFWWACERAAF----RCN 140

  Fly   451 ---GPDGLKKCLVSKLFDVC------PRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAY 506
               .|:...:|.:.|..::.      ||    ..|.:...|:...|.::.|
Zfish   141 IARTPESALECFLDKHHEIVIIDGRHPR----YFEAEAICRMIRATKLSEH-------------- 187

  Fly   507 QDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVI----------NKMNGECFSEIDEKVF 561
                            |..|..||...|..:...|..::          |.....|::|:
Zfish   188 ----------------TVILAVMPQTPSDQEEPSVLPLLSAGFSRRYLENSSVSACYNEL----- 231

  Fly   562 SSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFE--EQSTIEHMVFRILTHMQSLIQCQR 624
                    |.|.:.::  ::|.:::....:........|  |.|:.:|::..:....:.::...|
Zfish   232 --------IQLEHGEV--RAQFKLRACNAVFTALEQCQEAVEISSEDHVIQYVNPAFEKMMGYHR 286

  Fly   625 VQIL-----LVHEADKGS----------FSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGH 674
            .:::     .:..:||.|          ..:..:::....|..::......|....|: :|..|.
Zfish   287 GELIGKELTELPRSDKNSADLLDTINTCIKKGKEWQGIYFSRRKSGDSIQQYVKITPV-VGQGGK 350

  Fly   675 VATTGETVNVPNAYED-----------------------------DRFDASVDENSCFKHRS--- 707
            :.   ..|::...|.|                             ||...|||..|...|.|
Zfish   351 IR---HFVSIKRPYSDNHRQVHKLSKEEKCCGEHSQSECNSLRHKDRRKESVDVRSISSHSSDAP 412

  Fly   708 ------------ILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMY 760
                        |..|.|:..:.::|.:|....:.:.:...:..:..:|.        :..|.:|
Zfish   413 SLQNRRYSSMARIHSMTIEAPITKVINIINAAQESSPVTVAEALDRVLEI--------LRTTELY 469

  Fly   761 EKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLR---------------------------VPS 798
            ...:.:......|.:::    ...|.:.  ||||.                           :|.
Zfish   470 SPQLASKEDDPHTNDLV----GGLMSDG--LRRLSGNEYIFSKSALQNMSQSQLGVPVPLNDIPP 528

  Fly   799 AVHFRLHD---FKFDDIHFEDDDTLKAC----LRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRN 856
            ::...|::   ::|:.:..|.....:..    |::|......|..:.....|..||..::.||.:
Zfish   529 SIAELLNEEEQWEFNILELEAATHKRPLSYLGLKIFSAFGVCEFLNCSESTLRLWLQVIETNYHS 593

  Fly   857 V-TYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLA 920
            . :|||..||.:|.......|...:......:::.:|.::....||:||.|..|||...|.|.||
Zfish   594 SNSYHNSTHAADVLHATAYFLRKERVKASLDQLDEVAALLAATVHDVDHPGRTNSFLCNAGSELA 658

  Fly   921 QLYS-TSTMEHHH----FDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRG 980
            .||: |:.:|.||    |.  |.:.:|..| |..|:....:..:.:.:.|.:|:|::..:|:...
Zfish   659 ILYNDTAVLESHHAALAFQ--LTVRDSKCN-IFKNMERTQFRTLRQAIIDMVLATEMTRHFEHVN 720

  Fly   981 PFLESVSQPTSYWVAE--------------------EPRALLRAMSMTVCDLSAITKPWEIEKRV 1025
            .|:.|:::|.|. :.|                    |.|.|::.|.:...|::...:|.|:....
Zfish   721 KFVNSINKPMSA-IEETSSNSEGSDCEGQASIRNSPENRLLIKRMLIKCADVANPCRPLELCIEW 784

  Fly  1026 ADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIY---EAFATLSDKLE 1087
            |..:|.|:|.|.|.||::.....:.:.:| ....:|..|::|||.....::   :|||:|...:|
Zfish   785 AGRISEEYFAQTDEEKRQGLPVVMPVFDR-NTCSIPKSQISFIDYFITDMFDAWDAFASLPGLME 848

  Fly  1088 PLVEGVRDNRGHWIDLADVVKTKTSQDQEP 1117
            .|.|    |..:|.:| |.:|.|:.:...|
Zfish   849 HLAE----NYKYWKNL-DEMKCKSLRPPPP 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	30/208 (14%)
		GAF	611..762	CDD:214500	28/209 (13%)
		PDEase_I	859..1094	CDD:278654	69/262 (26%)
pde8b	XP_009293455.1	PDE8	1..47	CDD:285793
		TIM_phosphate_binding	<143..>212	CDD:304361	15/102 (15%)
		PAS_9	260..357	CDD:290162	14/100 (14%)
		PAS	264..357	CDD:238075	12/96 (13%)
		PDEase_I	597..850	CDD:278654	67/257 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589313
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850