DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde11 and pde3a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_009298269.1	Gene:	pde3a / 567051	ZFINID:	ZDB-GENE-041210-23	Length:	1124	Species:	Danio rerio

Alignment Length:	493	Identity:	102/493 - (20%)
Similarity:	188/493 - (38%)	Gaps:	132/493 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   825 RMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQ------WWK 883
            |:|:|....|.|.|.......:..:::..||::.|||..||.:|...::.:  |||      ..:
Zfish   654 RLFVDTGLFETFKIPVREFMNYFHALENGYRDIPYHNRIHATDVLHAVWYL--TTQPVPGLPTLR 716

  Fly   884 IFGE------------------------------------IECLALIIGCLCHDLDHRGTNNSFQ 912
            ..|.                                    :|.:||.:....||.||.|..|:|.
Zfish   717 TLGSSDSDSGLAHGRMKYLMSRTNAVEEEGYGCLSGLIPALELMALYVAAAMHDYDHPGRTNAFL 781

  Fly   913 IKASSPLAQLYS-TSTMEHHHFDQCL-MILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVY 975
            :..|:|.|.||: .|.:|:||..... :.::.|....||:|...::.|...::.:|||:|||..:
Zfish   782 VATSAPQAVLYNDRSVLENHHAASAWNLFMSRPEYNFLASLDHMEFKRFRFLVIEAILATDLKKH 846

  Fly   976 FKKRGPFLESVSQPTSY---WVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQG 1037
            |.....|...|......   |..|..|.|:..|.:.:.|::...|..::..:..:.:.:||:|||
Zfish   847 FDFLAEFNAKVGDDGCSGIDWTNENDRLLVCQMCIKLADINGPLKCKDLHLQWTEGIVNEFYEQG 911

  Fly  1038 DMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWID 1102
            | |:..|.: ||.........:|..:|.:||..|..|:..::.  |..|.|         |.|:.
Zfish   912 D-EESSLGL-PISPFMDRSAPQLAKLQESFITHIVGPLCSSYD--SAALMP---------GRWVH 963

  Fly  1103 L----ADVVKTKTSQDQEPEEEQQQQNVISNGD--------------C--------------KAM 1135
            .    .|.|:.::.::.|...|:::::..::.:              |              |.:
Zfish   964 PLPKDGDEVEDESEEEDEDTAEEEEEDASTSSELSQKPAPKKRRKVFCQISHHLLENHEMWKKVI 1028

  Fly  1136 SDDDVAASEAE------------VAVDSPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQPSDD 1188
            :::..:.:|.|            :|:|...|:..                       :..:|:||
Zfish  1029 AEESQSQTEGEESTCLSTTPEPILAIDEEEEEPG-----------------------SKEEPTDD 1070

  Fly  1189 DNDVDADADD--VDEQAAEENGHDAE-VDEASCRSNST 1223
            ..:...:.::  |.|...|....|.| |:||..::..|
Zfish  1071 QGEGSTEEEEGPVPEDTHETQEPDGETVEEADEKNTET 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500
		PDEase_I	859..1094	CDD:278654	69/281 (25%)
pde3a	XP_009298269.1	PDEase_I	688..947	CDD:278654	65/262 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589298
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850