Protein Alignment Pde11 and pde4d

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_009302145.1
• Gene: pde4d / 566998
• ZFINID: ZDB-GENE-081105-16
• Length: 769
• Species: Danio rerio
• Alignment Length: 856
• Identity: 177/856 - (20%)
• Similarity: 317/856 - (37%)
• Gaps: 227/856 - (26%)

  Fly   454 GLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGH------VAESGEPVNIP--------- 503
            ||.:.||..|        .|.:.||:..|        ||      ::....|.|.|
Zfish    23 GLNEDLVKIL--------RENLLQQERPR--------GHRRSPSSISPRLSPRNSPRLLRRMLLN 71

  Fly   504 -DAYQDERF----NC-EIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECF---SEIDEK 559
             :.::..||    .| ::|:.|......|  .|:......:|..|..::....|.|   |:.|
Zfish    72 NNIHKQRRFTVAHTCFDVDNGTSSGRSPL--DPMASPGSGLILQANFVHSQRRESFLYRSDSD-- 132

  Fly   560 VFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQR 624
                              |:.|...:.||              |:|...:     |...:|....
Zfish   133 ------------------YDLSPKSMSRN--------------SSIASDI-----HGDDMIVTPF 160

  Fly   625 VQILLVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYE 689
            .|:|......:.:|:.:     .::.:|.:.::.||..:..||.           :|.....||:
Zfish   161 AQVLASLRTVRNNFAAL-----TNVQQERSNNKRSPMCNPPPIT-----------KTSYTEEAYQ 209

  Fly   690 D-------------DRFDA-----SVDENSCFKHRSIL------CMAIKNSLGQIIGVIQ--LIN 728
            .             |:.:.     ||.|.:..|.:.:|      ...:..|..|:...|.  .::
Zfish   210 KLATETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISSTFLD 274

  Fly   729 KFNELDF-----TKNDENFVEAFAIFCGMG--IHNTHMYEKAIVAMAKQSVTLEVLSYHASATMD 786
            |.||::.     .|:.|......:...|:.  .|::.:....|.....::.|.:.|    :..::
Zfish   275 KQNEVEMPSPQSQKDKEKKKRPMSQISGVKKLTHSSSLTNSNIPRFGVKTETEDEL----AKELE 335

  Fly   787 EAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACL-RMFLDLDFVERFHIDYEVLCRWLLSV 850
            :.::           :.|:.||..:  |..:..|...: .:|.:.|.::.|.|..:....:|:::
Zfish   336 DVNK-----------WGLNVFKVSE--FSGNRPLTVMMYTIFQERDLLKTFKIPLDTFITYLMTL 387

  Fly   851 KKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIK 914
            :.:|. :|.|||..||.:|.|....:|:|.....:|.::|.||.|.....||:||.|.:|.|.|.
Zfish   388 EDHYHADVAYHNNIHAADVTQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN 452

  Fly   915 ASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKK 978
            .:|.||.:|: :|.:|:||......:|......|..||:......:.:::.|.:|:||::.:...
Zfish   453 TNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNL 517

  Fly   979 RGPF--LESVSQPTSYWV------AEEPRALLRAMSMTVC-DLSAITKPWEIEKRVADLVSSEFF 1034
            ....  :....:.||..|      ::..:.|   .:|..| |||..|||.::.::..|.:..|||
Zfish   518 LADLKTMVETKKVTSSGVLLLDNYSDRIQVL---QNMVHCADLSNPTKPLQLYRQWTDRIMEEFF 579

  Fly  1035 EQGDMEKQE-LNITPI-DIMNREKEDELPMMQVNFIDSICLPIYEAFATL-SDKLEPLVEGVRDN 1096
            .|||.|::. :.|:|: |..|...|..    ||.|||.|..|::|.:|.| ....:.:::.:.||
Zfish   580 SQGDRERERGMEISPMCDKHNASVEKS----QVGFIDYIVHPLWETWADLVHPDAQDILDTLEDN 640

  Fly  1097 RGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDSPSEKASVNGS 1161
            | .|.        :::..|.|                                 ||:...|..|.
Zfish   641 R-EWY--------QSTIPQSP---------------------------------SPALDTSSEGR 663

  Fly  1162 NVANNSSNTNKKIAVASHPTSTQPSDDDNDVDADADDVDEQAAEENGHDAEVDEASCRSNST-CS 1225
            ..|.......:         .|...|.::|.:.|:....|:..||.    |.:|.||..:.| |:
Zfish   664 RAAGQEKFQFE---------LTLEEDGESDTEKDSGSPPEEDEEEE----EEEENSCSDSKTLCT 715

  Fly  1226 SSTASSCLSTP 1236
            ..  |.|...|
Zfish   716 QD--SECTEIP 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	28/151 (19%)
		GAF	611..762	CDD:214500	29/183 (16%)
		PDEase_I	859..1094	CDD:278654	73/247 (30%)
pde4d	XP_009302145.1	PDEase_I	397..634	CDD:306695	73/243 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589312
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750