DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde11 and si:dkey-219c10.4

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_017213373.2	Gene:	si:dkey-219c10.4 / 562357	ZFINID:	ZDB-GENE-081105-151	Length:	529	Species:	Danio rerio

Alignment Length:	544	Identity:	136/544 - (25%)
Similarity:	226/544 - (41%)	Gaps:	123/544 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   660 PYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVI 724
            |.::.|||               :.|.....|.|.|:.:...    ..||  .:.|:.|.||.:.
Zfish    14 PEQAEFPI---------------DCPAQDVKDLFRAAAEAGP----HDIL--KLYNTKGNIINIS 57

  Fly   725 QLINKFNELDFTKNDENFVEAFAIFC-----------GMGIHNTHMYEKAIVAMAKQSVT----- 773
            ..:...:...:.|     :|..|..|           .:|...|.| ||.:.::.|:.:|
Zfish    58 PQLASNSPHSYYK-----LEVVAADCNSELLGSELAVALGFDLTSM-EKRLQSLEKRILTEAAET 116

  Fly   774 --------------------LEVLS------------------YHASA---TMDEAHRLRR---- 793
                                :|.||                  ||...   |.:|...:|.
Zfish   117 PAIVYEMKRQVESFREKLESVEHLSWLGLFKDMSEGTHKPSPFYHKRTLRKTREECEHVREKFLQ 181

  Fly   794 ---LRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYR 855
               |.|...|...|....||:..:||.:.:.....|:.||||:..|:|:.:||.::|..|.:.|.
Zfish   182 MSSLEVSEEVRQYLKTPTFDNWQWEDAEIMVLLQVMYTDLDFISTFNIEPDVLQQFLYEVYRRYN 246

  Fly   856 NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLA 920
            |:.:||::|.|.|.|||:.::..|........|:.|.::...:||||||.|.||::||.|.:.||
Zfish   247 NIPFHNFKHCFCVTQMMYGLIWLTDLRSKIDSIDLLIMLTSAVCHDLDHTGYNNAYQINARTELA 311

  Fly   921 QLYS-TSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVY------FKK 978
            ..|: .|.:|:||......||....:.|..||.::.|.|:...:...||:||::.:      ||.
Zfish   312 LRYNDISPLENHHCAVAFEILEKTESNIFRNLPTEQYKRIREGIIKCILATDMSRHTDILNKFKA 376

  Fly   979 RGPFLESVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE 1043
            ..|..:        :..::.|.:|..:.:.|.|:|...:|.::.:...|.:..|||.|.||||.|
Zfish   377 ILPVFD--------FGNKDHRDVLMMIMIKVSDISNEARPMDVAEPWLDCLLQEFFNQSDMEKLE 433

  Fly  1044 -LNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEP-LVEGVRDNRGHWIDLADV 1106
             |.:||  .|:|:|..: |..|..||..:..|::...|.|...||. :::.||....::.::...
Zfish   434 GLPVTP--FMDRDKVTK-PSSQTGFIRFVLFPLFIELANLFPCLEQHIIDPVRKALDYYTEMEKA 495

  Fly  1107 VK------------TKTSQDQEPE 1118
            ::            .|||..:||:
Zfish   496 LEREKQNRALNETTVKTSTSKEPD 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	21/112 (19%)
		PDEase_I	859..1094	CDD:278654	75/243 (31%)
si:dkey-219c10.4	XP_017213373.2	PDEase_I	250..478	CDD:306695	75/238 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820