Protein Alignment Pde11 and pde6b

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_685002.1
• Gene: pde6b / 559332
• ZFINID: ZDB-GENE-090421-2
• Length: 854
• Species: Danio rerio
• Alignment Length: 846
• Identity: 252/846 - (29%)
• Similarity: 428/846 - (50%)
• Gaps: 109/846 - (12%)

  Fly   394 SRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKKC 458
            |..|:..::|..:.::|:.|:...:.:..:..|||:.:|.|::|||.|||:.:.|    :|:.:
Zfish    47 SFKEIVSVEEGAIFYDLITDMQENVNMEKVIFKILKRISALIHADRCSLFMYRQR----NGIAE- 106

  Fly   459 LVSKLFDVCPRSTVEE--MEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGY 521
            |.::||:|...|.:::  :....|:......||.||||::.:.||:.|..||..|:..:|.||.|
Zfish   107 LATRLFNVNKDSELDDCVVAPDSEIVFPLDIGIVGHVAQTKKQVNVKDVTQDSHFSTFVDELTEY 171

  Fly   522 RTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQL--- 583
            .|..||..||.:.. ||:.|...:||..|..|::.|..:|..||:   :|..|.:::..|.|
Zfish   172 TTHNLLAAPIMNGK-DVVAVIMAVNKTTGPHFTDEDMDLFLKYLK---VGSLNLKIFHLSYLHNC 232

  Fly   584 EIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQI----------------LLVHE 632
            |.::.|:||..|..:|||.:.||....:.|..:::.:.|.|..:                :|:.|
Zfish   233 ETRKGQLLLWSANKVFEELTDIERQFHKALYTVRAYLNCDRYSVGLLDMTKEKEFFDIWPVLMGE 297

  Fly   633 ADKGS-----------FSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPN 686
            ....|           |.:|.|:..:  .:|:.....:|....:.:..|:..:||.:|...|:.|
Zfish   298 QPPYSGPVTPDGREIIFYKVIDYILH--GKEDIKVIPNPTADHWALASGLPTYVAESGFICNIMN 360

  Fly   687 AYEDD--RFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIF 749
            |..::  :|.....::|.:..:::|.:.|.|...:|:||....|:.:...|.::||..:||...|
Zfish   361 AASEEMFKFQTEALDDSGWTIKNVLSLPIVNKKEEIVGVATFYNRKDGKPFDEHDEQLMEALTQF 425

  Fly   750 CGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLR------------------- 795
            .|....||..|:|......::.:..:::.||.....||...:.:.|
Zfish   426 LGWSALNTDTYDKMNKLENRKDIAQDMVLYHVKCRDDEIQDILKTREYFDREPRDCEEEELLEIL 490

  Fly   796 ---VPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNV 857
               :|....|.::.|.|.|....:...:...::|:.::..|::|.:..|||.|::.||.|.||.:
Zfish   491 KKELPGPKKFEIYAFHFSDFDCTELQLVMCGIQMYYEVGVVKKFQVPQEVLVRFMYSVSKGYRRI 555

  Fly   858 TYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQL 922
            |||||||.|||.|.||.:|||.:..:.:.::|.:|:|.....||:|||||||.:|:|:.:|||:|
Zfish   556 TYHNWRHGFNVGQTMFTLLTTGKLKQYYTDLEVMAMITAGFLHDIDHRGTNNLYQVKSQNPLAKL 620

  Fly   923 YSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVS 987
            :.:|.:|.||.:....:|......|..||:......|..:::.||::||||:|||||..|.:.|.
Zfish   621 HGSSILERHHLEFGKFLLGEESLNIFQNLNRRQTEHVFHLIDIAIIATDLALYFKKRTMFQKIVD 685

  Fly   988 QPTSY-----WV----AEEPR-ALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQ 1042
            ...:|     |:    .|..| .::.||.||.|||||||||||::.:||..|::||:||||:|:.
Zfish   686 LSETYEERKKWIDFMSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALSVAAEFWEQGDLERT 750

  Fly  1043 ELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVV 1107
            .|...||.:|:|.|..|||.:|..|||.:|..:|:.|:....:::|:.:|:.:||.||
Zfish   751 VLEQQPIPMMDRNKAAELPKLQCGFIDFVCTFVYKEFSRFHPEIKPMFDGILNNRMHW------- 808

  Fly  1108 KTKTSQDQEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDSPSEKASVNGSNVANNSSNTNK 1172
                   :|.:||.:.:       .|||          |.||.:..|.|:.|.:| :|::..:..
Zfish   809 -------KERQEEYEAK-------LKAM----------EEAVKARQEAAAKNAAN-SNSTGGSGS 848

  Fly  1173 K 1173
            |
Zfish   849 K 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	53/163 (33%)
		GAF	611..762	CDD:214500	37/179 (21%)
		PDEase_I	859..1094	CDD:278654	102/244 (42%)
pde6b	XP_685002.1	GAF	72..210	CDD:214500	48/143 (34%)
		GAF	253..440	CDD:214500	40/188 (21%)
		PDEase_I	557..801	CDD:278654	101/243 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589302
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750