Protein Alignment Pde11 and Pde3a

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_061249.1
• Gene: Pde3a / 54611
• MGIID: 1860764
• Length: 1141
• Species: Mus musculus
• Alignment Length: 579
• Identity: 128/579 - (22%)
• Similarity: 214/579 - (36%)
• Gaps: 152/579 - (26%)

  Fly   646 ANDLSEE------EATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDENSCFK 704
            |.|||.:      ..:|...||....|.:    |....:|..:..||..:|
Mouse   571 APDLSPQIPPPSVICSSCGRPYSQGNPAD----GPSERSGPAMLKPNRTDD-------------- 617

  Fly   705 HRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENF-----VEAFAIFCGMGIHNTHMY-EKA 763
                        ..|:....:..|..:..|..:|:|..     .:..|..||.....|.:: :|.
Mouse   618 ------------TSQVTSDYETNNNSDSSDILQNEEEAECQREPQRKASACGTYTSQTMIFLDKP 670

  Fly   764 IVA-----MAKQSVTLEVLSYHASATMDEAHRLRRL--RVPSAVHFRLHDFKFDDIHFEDDDTLK 821
            |:|     |......::.|:.......|....:.|.  |:.|.|.:||
Mouse   671 ILAPEPLVMDNLDSIMDQLNTWNFPIFDLMENIGRKCGRILSQVSYRL----------------- 718

  Fly   822 ACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQ------ 880
                 |.|:...|.|.|.......:..:::..||::.|||..||.:|...::.:  |||
Mouse   719 -----FEDMGLFEAFKIPVREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYL--TTQPIPGLP 776

  Fly   881 --------------------------WWKIF-----------GEI---ECLALIIGCLCHDLDHR 905
                                      :.|::           |.|   |.:||.:....||.||.
Mouse   777 SVIGDHGSASDSDSDSGFTHGHMGYVFSKMYHVPDDKYGCLSGNIPALELMALYVAAAMHDYDHP 841

  Fly   906 GTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCL-MILNSPGNQILANLSSDDYCRVIRVLEDAIL 968
            |..|:|.:..|:|.|.||: .|.:|:||..... :.::.|....|.||...::.....::.:|||
Mouse   842 GRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAIL 906

  Fly   969 STDLAVYFKKRGPFLESVSQPTSY-WVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSE 1032
            :|||..:|.....|...|:..... |..|..|.|:..|.:.:.|::...|..|:..|..:.::||
Mouse   907 ATDLKKHFDFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLRWTEGIASE 971

  Fly  1033 FFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNR 1097
            |:|||| |:..|.: ||.........:|..:|.:||..|..|:..::.  |..|.|
Mouse   972 FYEQGD-EEASLGL-PISPFMDRSAPQLANLQESFISHIVGPLCHSYD--SAGLMP--------- 1023

  Fly  1098 GHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDSPSEKA 1156
            |.|:|.:|    .:....:||||:::          |.:..:..|.|:.:|   |.:|:
Mouse  1024 GKWVDDSD----DSGDTDDPEEEEEE----------AETPHEDEACESSIA---PRKKS 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	22/127 (17%)
		PDEase_I	859..1094	CDD:278654	73/283 (26%)
Pde3a	NP_061249.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..111
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..483
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	505..654		18/112 (16%)
		PDEase_I	751..1012	CDD:278654	69/264 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1024..1060		11/49 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1120..1141

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844393
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850