DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde11 and PDE9A

DIOPT Version :9

Sequence 1:NP_001286044.1 Gene:Pde11 / 35107 FlyBaseID:FBgn0085370 Length:1451 Species:Drosophila melanogaster
Sequence 2:NP_002597.1 Gene:PDE9A / 5152 HGNCID:8795 Length:593 Species:Homo sapiens


Alignment Length:543 Identity:146/543 - (26%)
Similarity:237/543 - (43%) Gaps:83/543 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   654 ATSRTSPYESRFPINI-----GITGHVATT-GETVNVP---------------NAYEDDRFDASV 697
            |.|..:||:.| |:.|     |:.....|: |::...|               .|:|..:.:...
Human    69 ANSERTPYKVR-PVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRP 132

  Fly   698 DE-NSCFK-------HRSILCMAIKNSLGQIIGVIQLINKFNELDF-TKNDENFVEAFAIFCGMG 753
            .| ..|::       .|..|   |::.|.|:........|.|||.. ..|....:|......|:.
Human   133 REPQGCYQEGQRIPPEREEL---IQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLK 194

  Fly   754 IHNTHMYEKAIVAMAKQSVTLEVLSYHASAT--------MDEAHRLR-RLRVPSAVHFRLHDFKF 809
            :......:..|..|.      |.|:..:|.|        :|...:|. |..||:...:.|.....
Human   195 VVEIEKCKSDIKKMR------EELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETI 253

  Fly   810 D-------DIHFEDDDTLKACL-RMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAF 866
            :       |:...:.:.:.:|| .|:.||..|..|.|:...|.|||..|..||||..:||:||.|
Human   254 EALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCF 318

  Fly   867 NVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEH 930
            .|||||::::......:.|.:.:.|.|:...:||||||.|.||::||.|.:.||..|: .|.:|:
Human   319 CVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLEN 383

  Fly   931 HHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVA 995
            ||......||..|...|.:|:..|.:.::.:.:...||:||:|.:.:....|.|.:.  ...:..
Human   384 HHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME--NFDYSN 446

  Fly   996 EEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDE 1059
            ||...||:.:.:..||:|...:|.|:.:...|.:..|:|.|.|.||.| |.:.|  .|:|:|..:
Human   447 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAP--FMDRDKVTK 509

  Fly  1060 LPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVR-----DNRGHWIDLA---DVVK-------T 1109
             ...|:.||..:.:|::|...    ||.|:||.:.     ::|..:.:|.   |.:|       :
Human   510 -ATAQIGFIKFVLIPMFETVT----KLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDS 569

  Fly  1110 KTSQDQEPEEEQQQQNVISNGDC 1132
            .||...|...|:.:....|.|||
Human   570 LTSGATEKSRERSRDVKNSEGDC 592

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde11NP_001286044.1 GAF 420..582 CDD:214500
GAF 611..762 CDD:214500 27/137 (20%)
PDEase_I 859..1094 CDD:278654 77/236 (33%)
PDE9ANP_002597.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 87..141 8/53 (15%)
PDEase_I 311..539 CDD:278654 77/236 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 564..593 8/29 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D904682at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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