Protein Alignment Pde11 and PDE9A

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_002597.1
• Gene: PDE9A / 5152
• HGNCID: 8795
• Length: 593
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 146/543 - (26%)
• Similarity: 237/543 - (43%)
• Gaps: 83/543 - (15%)

  Fly   654 ATSRTSPYESRFPINI-----GITGHVATT-GETVNVP---------------NAYEDDRFDASV 697
            |.|..:||:.| |:.|     |:.....|: |::...|               .|:|..:.:...
Human    69 ANSERTPYKVR-PVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRP 132

  Fly   698 DE-NSCFK-------HRSILCMAIKNSLGQIIGVIQLINKFNELDF-TKNDENFVEAFAIFCGMG 753
            .| ..|::       .|..|   |::.|.|:........|.|||.. ..|....:|......|:.
Human   133 REPQGCYQEGQRIPPEREEL---IQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLK 194

  Fly   754 IHNTHMYEKAIVAMAKQSVTLEVLSYHASAT--------MDEAHRLR-RLRVPSAVHFRLHDFKF 809
            :......:..|..|.      |.|:..:|.|        :|...:|. |..||:...:.|.....
Human   195 VVEIEKCKSDIKKMR------EELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETI 253

  Fly   810 D-------DIHFEDDDTLKACL-RMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAF 866
            :       |:...:.:.:.:|| .|:.||..|..|.|:...|.|||..|..||||..:||:||.|
Human   254 EALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCF 318

  Fly   867 NVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEH 930
            .|||||::::......:.|.:.:.|.|:...:||||||.|.||::||.|.:.||..|: .|.:|:
Human   319 CVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLEN 383

  Fly   931 HHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVA 995
            ||......||..|...|.:|:..|.:.::.:.:...||:||:|.:.:....|.|.:.  ...:..
Human   384 HHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME--NFDYSN 446

  Fly   996 EEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDE 1059
            ||...||:.:.:..||:|...:|.|:.:...|.:..|:|.|.|.||.| |.:.|  .|:|:|..:
Human   447 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAP--FMDRDKVTK 509

  Fly  1060 LPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVR-----DNRGHWIDLA---DVVK-------T 1109
             ...|:.||..:.:|::|...    ||.|:||.:.     ::|..:.:|.   |.:|       :
Human   510 -ATAQIGFIKFVLIPMFETVT----KLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDS 569

  Fly  1110 KTSQDQEPEEEQQQQNVISNGDC 1132
            .||...|...|:.:....|.|||
Human   570 LTSGATEKSRERSRDVKNSEGDC 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	27/137 (20%)
		PDEase_I	859..1093	CDD:459723	77/235 (33%)
PDE9A	NP_002597.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..141		8/53 (15%)
		PDEase_I	311..539	CDD:459723	77/236 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	564..593		8/29 (28%)