Protein Alignment Pde11 and PDE8A

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_002596.1
• Gene: PDE8A / 5151
• HGNCID: 8793
• Length: 829
• Species: Homo sapiens
• Alignment Length: 887
• Identity: 169/887 - (19%)
• Similarity: 323/887 - (36%)
• Gaps: 230/887 - (25%)

  Fly   356 STGG-----ASGAGGAPSLGGSG------GAGNGHQYPYYHCHQRPQRLSRNELKQLDEKELIFE 409
            |:||     .......|...|:|      ..|:|.:.........|.|..:::|:.|    |:|.
Human    27 SSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVL----LVFT 87

  Fly   410 LVKDICN------------------------------------------ELEVRTLCH-----KI 427
            ...:.||                                          :|:...||.     |:
Human    88 KEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKL 152

  Fly   428 LQN---VSILLNADRGSL----FLVQG---RCNGPDGLKKCLVSKLFDVCPRSTVEEMEQQDEVR 482
            .:|   |.::...||..|    |:..|   |......:..|....|       .:|..|.:.:::
Human   153 SENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELL-------QLEFGEVRSQLK 210

  Fly   483 VAWGTGIAGHVAESGEPVNIPDAYQDERF----NCEIDSLTGYRTKALLCMPIKDSSGDVIG--V 541
            :.....:...:..|.:.:.|.   .::||    |...::..||:            ||::||  :
Human   211 LRACNSVFTALENSEDAIEIT---SEDRFIQYANPAFETTMGYQ------------SGELIGKEL 260

  Fly   542 AQV-INKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLY---EKSQLEIKRNQVLLDLARMIFEEQ 602
            .:| ||:...:....|:..:        .||.....:|   :|:...|::|..::.    :..:.
Human   261 GEVPINEKKADLLDTINSCI--------RIGKEWQGIYYAKKKNGDNIQQNVKIIP----VIGQG 313

  Fly   603 STIEHMV--FRIL---THMQSLIQCQRVQILLVH---------EADKGSFS-RVFDFEANDLSEE 652
            ..|.|.|  .|:.   ...:.:.:|.:..   .|         :..|||.. :.....|.::|.:
Human   314 GKIRHYVSIIRVCNGNNKAEKISECVQSD---THTDNQTGKHKDRRKGSLDVKAVASRATEVSSQ 375

  Fly   653 EATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSL 717
            ...|..:...| ..|...||       :.:|:.||.::..                 .|.:..:|
Human   376 RRHSSMARIHS-MTIEAPIT-------KVINIINAAQESS-----------------PMPVTEAL 415

  Fly   718 GQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGM---GIHNTHMYEKAIVAMAKQSVTLEVLSY 779
            .:::.:::....::.....|:|:  ..|..:..|:   |:......|..:.....|.|:..:::
Human   416 DRVLEILRTTELYSPQFGAKDDD--PHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIIT- 477

  Fly   780 HASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIH-FEDDDTLKAC----------LRMFLDLDFV 833
              ..::|:        ||..:...:.:.::.|.. ||    |:|.          |:||......
Human   478 --PISLDD--------VPPRIARAMENEEYWDFDIFE----LEAATHNRPLIYLGLKMFARFGIC 528

  Fly   834 ERFHIDYEVLCRWLLSVKKNYRNVT-YHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGC 897
            |..|.....|..||..::.||.:.. |||..|:.:|.......|:..:..:....|:.:|.:|..
Human   529 EFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAA 593

  Fly   898 LCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHF----------DQCLMILNSPGNQILANL 951
            ..||:||.|..|||...|.|.||.||: |:.:|.||.          |:|         .|..|:
Human   594 TIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKC---------NIFKNM 649

  Fly   952 SSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQP-----------------TSYWVAEEPR 999
            ..:||..:.:.:.|.:|:|::..:|:....|:.|:::|                 .:.....|.|
Human   650 ERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENR 714

  Fly  1000 ALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQ 1064
            .|::.|.:...|:|...:|.:.....|..:|.|:|.|.|.|||:.....:.:.:| ....:|..|
Human   715 TLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDR-NTCSIPKSQ 778

  Fly  1065 VNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADV 1106
            ::|||.....:::|:....| |..|::.:.:|..:|..|.::
Human   779 ISFIDYFITDMFDAWDAFVD-LPDLMQHLDNNFKYWKGLDEM 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	34/186 (18%)
		GAF	611..762	CDD:214500	23/166 (14%)
		PDEase_I	859..1093	CDD:459723	66/261 (25%)
PDE8A	NP_002596.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..46		4/18 (22%)
		RpfG	73..>169	CDD:442663	15/99 (15%)
		PAS	219..>324	CDD:441804	24/131 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..360		3/21 (14%)
		Involved in RAF1-binding. /evidence=ECO:0000269|PubMed:23509299	454..461		0/6 (0%)
		PDEase_I	555..806	CDD:459723	66/261 (25%)