Protein Alignment Pde11 and PDE7A

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001229247.1
• Gene: PDE7A / 5150
• HGNCID: 8791
• Length: 482
• Species: Homo sapiens
• Alignment Length: 345
• Identity: 89/345 - (25%)
• Similarity: 161/345 - (46%)
• Gaps: 31/345 - (8%)

  Fly   803 RLHDFKFDDIHFE----DDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVT-YHNW 862
            ::.::.||...|:    .:..:.....:|.....:|.||:|...|.|:|:.::::|.:.. |||.
Human   150 KVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNA 214

  Fly   863 RHAFNVAQMMFAIL-------TTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLA 920
            .||.:|.|.|...|       :.|.|       :.|..:|....|||||.|.|..|.||.:..||
Human   215 VHAADVTQAMHCYLKEPKLANSVTPW-------DILLSLIAAATHDLDHPGVNQPFLIKTNHYLA 272

  Fly   921 QLY-STSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLE 984
            .|| :||.:|:||:...:.:|...|  :.::|..:...::...:...||:||::...:....|..
Human   273 TLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRS 335

  Fly   985 SVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQ-ELNITP 1048
            .:.:..........|.|:..|::...|:....:.||:.|:.::.|:.|||.|||:||: .|.::|
Human   336 HLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSP 400

  Fly  1049 IDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSD-KLEPLVEG-VRDNRGHWIDLADVVKTKT 1111
              :.:|..| .:..:|:.|:..:..|::..:|..|: :|...:.| |..|:..|..|.....:..
Human   401 --LCDRHTE-SIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSE 462

  Fly  1112 SQDQEPEEEQQ---QQNVIS 1128
            ..|...|...|   |:|.:|
Human   463 DTDAAFELNSQLLPQENRLS 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500
		PDEase_I	859..1093	CDD:459723	67/244 (27%)
PDE7A	NP_001229247.1	PDEase_I	211..431	CDD:459723	64/231 (28%)