DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pde11 and PDE6C

DIOPT Version :9

Sequence 1:NP_001286044.1 Gene:Pde11 / 35107 FlyBaseID:FBgn0085370 Length:1451 Species:Drosophila melanogaster
Sequence 2:NP_006195.3 Gene:PDE6C / 5146 HGNCID:8787 Length:858 Species:Homo sapiens


Alignment Length:817 Identity:266/817 - (32%)
Similarity:416/817 - (50%) Gaps:85/817 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   393 LSRNELKQLDEKELIFELVKDICNELEV-RTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLK 456
            :|.:||.|::|..|..||:..:..|... ....|:.||.::.||.|||.|:||.:.|...|:   
Human    48 MSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPE--- 109

  Fly   457 KCLVSKLFDVCPRSTVEE--MEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLT 519
              :.|:|.||.|.|..|:  :....||......||.|..|.:.:..|:||..::..|:..:|..|
Human   110 --VASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQT 172

  Fly   520 GYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLE 584
            ||.||.||..||.... :|:.|...:||:|...||:.||:|||.||.|..|.||.........:|
Human   173 GYVTKNLLATPIVVGK-EVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIE 236

  Fly   585 IKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVH------------------ 631
            .:|:|:|:..|..:|||.:.:|....:.|..::|.:.|:|..|.|:.                  
Human   237 SRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEV 301

  Fly   632 EADKG---------SFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNA 687
            |..||         :|.::.|:..:  .:||.....:|....:.:..|:..:||..|...|:.||
Human   302 EPYKGPKTPDGREVNFYKIIDYILH--GKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNA 364

  Fly   688 YEDDRF---DASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIF 749
            ..|:.|   ...|||.. :..:::|.:.|.|....|:||....|:.:...|.::||...|....|
Human   365 PADEYFTFQKGPVDETG-WVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQF 428

  Fly   750 CGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLR------------------- 795
            .|..:.||..|:|......::.:..|:|.....||.:|...:.:.:                   
Human   429 LGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAI 493

  Fly   796 ----VPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRN 856
                :|......|::|:|.|....:...:|..:|:|.:::.||:|.:..|||.||:.:|:|.||.
Human   494 LKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRA 558

  Fly   857 VTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQ 921
            ||||||||.|||.|.||.:|.|.:..|.:.::|..|::....|||:|||||||.:|:|::||||:
Human   559 VTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLAR 623

  Fly   922 LYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESV 986
            |:.:|.:|.||.:....:|......|..||:...:..||.:.|.||::||||:|||||..|.:.|
Human   624 LHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIV 688

  Fly   987 --------SQPTSYWVAEEP--RALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEK 1041
                    .:....:|..:|  :.::.||.||.|||||||||||::.:||.:|::||:||||:|:
Human   689 DACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLER 753

  Fly  1042 QELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADV 1106
            ..|...||.:|:|.|.||||.:||.|||.:|..:|:.|:....::.|::.|:::||..|..|||.
Human   754 TVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADE 818

  Fly  1107 VKTKTSQDQEPEEEQQQQNVISNGDCKAMSD----DD 1139
            ...|....:|..::|:      .|..||..|    ||
Human   819 YDAKMKVIEEEAKKQE------GGAEKAAEDSGGGDD 849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde11NP_001286044.1 GAF 420..582 CDD:214500 58/164 (35%)
GAF 611..762 CDD:214500 42/180 (23%)
PDEase_I 859..1094 CDD:278654 105/244 (43%)
PDE6CNP_006195.3 GAF 80..231 CDD:214500 58/156 (37%)
GAF 256..443 CDD:214500 44/189 (23%)
PDEase_I 561..806 CDD:278654 105/244 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 830..858 7/26 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154138
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D904682at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.750

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