DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and PDE6A

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_000431.2	Gene:	PDE6A / 5145	HGNCID:	8785	Length:	860	Species:	Homo sapiens

Alignment Length:	878	Identity:	261/878 - (29%)
Similarity:	441/878 - (50%)	Gaps:	115/878 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 GHQYPYYHCHQRPQRLS--------------RNELKQLDEKELIFELVKDICNELEVRTLCHKIL 428
            |....||:.|.|.:.:|              .:....::|.|:||:|::|....|:.......::
Human    18 GFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEIIFDLLRDFQENLQTEKCIFNVM 82

  Fly   429 QNVSILLNADRGSLFLVQGRCNGPDGLKKCLVSKLFDVCPRSTVEE---MEQQDEVRVAWGTGIA 490
            :.:..||.|||.|||:.:.|    :|:.: |.::||:|...:.:|:   |..| |:......||.
Human    83 KKLCFLLQADRMSLFMYRTR----NGIAE-LATRLFNVHKDAVLEDCLVMPDQ-EIVFPLDMGIV 141

  Fly   491 GHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSE 555
            ||||.|.:..|:|:..:||.|...:|.||.|:||.:|..||.:.. ||:.:...:||::|..|::
Human   142 GHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILASPIMNGK-DVVAIIMAVNKVDGSHFTK 205

  Fly   556 IDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLI 620
            .||::...||.|..:.::...|......|.:|.|:||.....:|||.:.||....:.|..:::.:
Human   206 RDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFL 270

  Fly   621 QCQRVQI----------------LLVHEADKGS-----------FSRVFDFEANDLSEEEATSRT 658
            .|.|..:                :|:.|....|           |.:|.|:..:  .:|:.....
Human   271 NCDRYSVGLLDMTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILH--GKEDIKVIP 333

  Fly   659 SPYESRFPINIGITGHVATTGETVNVPNAYEDDRF---DASVDENSCFKHRSILCMAIKNSLGQI 720
            :|....:.:..|:..:||..|...|:.||..:|.|   ...:|| |.:..:::|.|.|.|...:|
Human   334 NPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDE-SGWMIKNVLSMPIVNKKEEI 397

  Fly   721 IGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATM 785
            :||....|:.:...|.:.||..:|:...|.|..:.|...||.......::.:..:::.||.....
Human   398 VGVATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDN 462

  Fly   786 DEAHRLRRLR----------------------VPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFL 828
            :|..::.:.|                      :|.|..:.::.|.|.|:...:.:.:|..::|:.
Human   463 EEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYY 527

  Fly   829 DLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLAL 893
            :|..|::|||..|.|.|::.|:.|.||.:|||||||.|||.|.||::|.|.:..:.|.::|.||:
Human   528 ELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAM 592

  Fly   894 IIGCLCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCR 958
            :....|||:|||||||.:|:|:.:|||:|:.:|.:|.||.:....:|......|..||:...:..
Human   593 VTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEH 657

  Fly   959 VIRVLEDAILSTDLAVYFKKRGPFLESVSQP---------TSYWVAEEPR-ALLRAMSMTVCDLS 1013
            .|.:::.||::||||:|||||..|.:.|.|.         |.|.:.|:.| .::.||.||.||||
Human   658 AIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACDLS 722

  Fly  1014 AITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEA 1078
            |||||||::.:||.||::||:||||:|:..|...||.:|:|.|.||||.:||.|||.:|..:|:.
Human   723 AITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKE 787

  Fly  1079 FATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCKAMSDDDVAAS 1143
            |:...:::.|:::|:.:||..|..|||....|....:|.:::||                   ::
Human   788 FSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQ-------------------SA 833

  Fly  1144 EAEVAVDSPSEKASVNGSNVANNSSNTNKKIAV 1176
            ::..|.:.|       |.|.:...:.|:|...:
Human   834 KSAAAGNQP-------GGNPSPGGATTSKSCCI 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	51/164 (31%)
		GAF	611..762	CDD:214500	39/180 (22%)
		PDEase_I	859..1094	CDD:278654	107/244 (44%)
PDE6A	NP_000431.2	GAF	75..232	CDD:214500	51/163 (31%)
		GAF	254..441	CDD:214500	42/189 (22%)
		PDEase_I	558..802	CDD:365964	106/243 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..860		9/65 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154153
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750