Protein Alignment Pde11 and PDE4D

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001098101.1
• Gene: PDE4D / 5144
• HGNCID: 8783
• Length: 809
• Species: Homo sapiens
• Alignment Length: 1012
• Identity: 212/1012 - (20%)
• Similarity: 367/1012 - (36%)
• Gaps: 296/1012 - (29%)

  Fly   297 PMDNGSVGGSCSNLQNVGGVV--AGQYQYNHQQHH------------HNHAHLHHSQHSHYQ--- 344
            |...||..||    .:.||..  |.::.:.|:|||            |.|.||........|
Human     9 PARAGSGEGS----DSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQP 69

  Fly   345 ------------------AGGAVGS-SSLGSTGGASGAGGAPSLGGSGGAGNGHQYPYYHCHQRP 390
                              .|.|.|. :|.|:||.....|.:.:          .:|.|
Human    70 QCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDT----------ERYLY------- 117

  Fly   391 QRLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGL 455
                                    |..:                   ||.|..:..|.   ..||
Human   118 ------------------------CRAM-------------------DRTSYAVETGH---RPGL 136

  Fly   456 KKCLVS--------KLFDV-----CPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQ 507
            ||..:|        :.|||     ..||.::.|...       |:|:   :.::    |...:.:
Human   137 KKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSP-------GSGL---ILQA----NFVHSQR 187

  Fly   508 DERFNCEIDSLTGYRTKALLCMPIKDSS------GD---VIGVAQVINKM-----NGECFSEIDE 558
            .|.|....||......|::    .::||      ||   |...|||:..:     |....:.:.:
Human   188 RESFLYRSDSDYDLSPKSM----SRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQD 248

  Fly   559 KVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQ 623
            :..|.....|            :|..|.:..:..:..:.:..|  |:|.:.:       .|.|.:
Human   249 RAPSKRSPMC------------NQPSINKATITEEAYQKLASE--TLEELDW-------CLDQLE 292

  Fly   624 RVQIL-LVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNA 687
            .:|.. .|.|.....|.|:.:.|...|||   .||:....|.|     |:.........|.:|:.
Human   293 TLQTRHSVSEMASNKFKRMLNRELTHLSE---MSRSGNQVSEF-----ISNTFLDKQHEVEIPSP 349

  Fly   688 YEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGM 752
            .:.:            |.:.      |..:.||.||.:|
Human   350 TQKE------------KEKK------KRPMSQISGVKKL-------------------------- 370

  Fly   753 GIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDD 817
             :|::.:...:|.....::...:||    :..:::.::           :.||.|:..::  ..:
Human   371 -MHSSSLTNSSIPRFGVKTEQEDVL----AKELEDVNK-----------WGLHVFRIAEL--SGN 417

  Fly   818 DTLKACLR-MFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQ 880
            ..|...:. :|.:.|.::.|.|..:.|..:|::::.:|. :|.|||..||.:|.|....:|:|..
Human   418 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPA 482

  Fly   881 WWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPG 944
            ...:|.::|.||.|.....||:||.|.:|.|.|..:|.||.:|: :|.:|:||......:|....
Human   483 LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEEN 547

  Fly   945 NQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWV------AEEPRAL 1001
            ..|..||:......:.:::.|.:|:||::.:.......  :....:.||..|      ::..:.|
Human   548 CDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 612

  Fly  1002 LRAMSMTVC-DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPI-DIMNREKEDELPMM 1063
               .:|..| |||..|||.::.::..|.:..|||.|||.|::. :.|:|: |..|...|..
Human   613 ---QNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKS---- 670

  Fly  1064 QVNFIDSICLPIYEAFATL-SDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVI 1127
            ||.|||.|..|::|.:|.| ....:.:::.:.||| .|.. :.:.::.:....:|||.:|.|.
Human   671 QVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNR-EWYQ-STIPQSPSPAPDDPEEGRQGQT-- 731

  Fly  1128 SNGDCKAMSDDDVAASEAEVAVDSPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQ-PSDDDND 1191
                       :....|..:..|..|:....:||.|..::|.::.|........||: |
Human   732 -----------EKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIP------ 779

  Fly  1192 VDADADDVDEQAAEEN-GHDAEVDEASC----RSNST 1223
                   :|||..||. |.:.|....:|    ||..|
Human   780 -------LDEQVEEEAVGEEEESQPEACVIDDRSPDT 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	34/188 (18%)
		GAF	611..762	CDD:214500	26/151 (17%)
		PDEase_I	859..1094	CDD:278654	73/247 (30%)
PDE4D	NP_001098101.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..107		24/101 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..364		4/38 (11%)
		PDEase_I	461..702	CDD:278654	73/247 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	710..729		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	739..809		20/82 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154159
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750