Protein Alignment Pde11 and PDE4C

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_000914.2
• Gene: PDE4C / 5143
• HGNCID: 8782
• Length: 712
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 133/555 - (23%)
• Similarity: 231/555 - (41%)
• Gaps: 122/555 - (21%)

  Fly   673 GHVATTGETVNVPNAYED----------DRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLI 727
            |.|.....:..:|.| ||          |..|..:|:        :..:..::|:|::..
Human   184 GPVGNPSSSNQLPPA-EDTGQKLALETLDELDWCLDQ--------LETLQTRHSVGEMAS----- 234

  Fly   728 NKF--------NELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLE--------V 776
            |||        ..|..|....|.|..:       |..|.:.::..|.:.|  ||.|        :
Human   235 NKFKRILNRELTHLSETSRSGNQVSEY-------ISRTFLDQQTEVELPK--VTAEEAPQPMSRI 290

  Fly   777 LSYHA---SATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLK----------------- 821
            ...|.   ||::..|      .||   .|.:...:.:.:..|.:||.|
Human   291 SGLHGLCHSASLSSA------TVP---RFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL 346

  Fly   822 --ACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWK 883
              ....:|.:.|.::.|.|..:.|..:||.::.:|. ||.|||..||.:|||....:|.|.....
Human   347 TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEA 411

  Fly   884 IFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQI 947
            :|.::|.||.:.....||:||.|.:|.|.|..:|.||.:|: .|.:|:||......:|.:....|
Human   412 VFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDI 476

  Fly   948 LANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWV------AEEPRALLRA 1004
            ..|||:.....:.|::.|.:|:||::.:.......  :....:.||..|      ::..:.|
Human   477 FQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVL--- 538

  Fly  1005 MSMTVC-DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDELPMMQVNF 1067
            .::..| |||..|||..:.::..|.:.:|||:|||.|::. |:|:|   |..:....:...||.|
Human   539 QNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP---MCDKHTASVEKSQVGF 600

  Fly  1068 IDSICLPIYEAFATL-SDKLEPLVEGVRDNRGHWI---------DLA------------DVVKTK 1110
            ||.|..|::|.:|.| ....:.|::.:.||| .|.         ||.            ::...:
Human   601 IDYIAHPLWETWADLVHPDAQDLLDTLEDNR-EWYQSKIPRSPSDLTNPERDGPDRFQFELTLEE 664

  Fly  1111 TSQDQEPEEEQQQQNVISNGDCKAMSDDDVAASEA 1145
            ..::.|.|||:.::..::. :...:.|.::.:.||
Human   665 AEEEDEEEEEEGEETALAK-EALELPDTELLSPEA 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	20/106 (19%)
		PDEase_I	859..1094	CDD:278654	74/246 (30%)
PDE4C	NP_000914.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..64
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..200		4/16 (25%)
		PDEase_I	387..628	CDD:278654	74/246 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	636..655		2/18 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	664..712		7/36 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154140
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750