DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and PDE4B

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001032418.1	Gene:	PDE4B / 5142	HGNCID:	8781	Length:	736	Species:	Homo sapiens

Alignment Length:	784	Identity:	168/784 - (21%)
Similarity:	294/784 - (37%)	Gaps:	204/784 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   507 QDERFNC-EIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECF----------SEIDEKV 560
            |.||... |.|.::...|..|..:|           :..|..::.|||          |.:|.:.
Human    59 QSERARTPEGDGISRPTTLPLTTLP-----------SIAITTVSQECFDVENGPSPGRSPLDPQA 112

  Fly   561 FSS-----YLQFCGIGLRNAQL-------YEKSQLEIKRNQ-----------VLLDLARMIFEEQ 602
            .||     :..|.|...|....       |:.|...:.||.           ::...|:::...:
Human   113 SSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLR 177

  Fly   603 STIEHMVFRILTHMQS--------------------------------------LIQCQRVQIL- 628
            |...:  |.|||::..                                      |.|.:.:|..
Human   178 SVRNN--FTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR 240

  Fly   629 LVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRF 693
            .|.|.....|.|:.:.|...|||   .||:....|.:     |:.........|.:|:..:.||
Human   241 SVSEMASNKFKRMLNRELTHLSE---MSRSGNQVSEY-----ISNTFLDKQNDVEIPSPTQKDR- 296

  Fly   694 DASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTH 758
                 |..  |.:.::.        ||.||.:|::. :.|:.|.     :..|    |:...|..
Human   297 -----EKK--KKQQLMT--------QISGVKKLMHS-SSLNNTS-----ISRF----GVNTENED 336

  Fly   759 MYEKAIVAMAKQSVTL-EVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKA 822
            ...|.:..:.|..:.: .|..|..:..:                                    .
Human   337 HLAKELEDLNKWGLNIFNVAGYSHNRPL------------------------------------T 365

  Fly   823 CL--RMFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKI 884
            |:  .:|.:.|.::.|.|..:....::::::.:|. :|.|||..||.:|||....:|:|.....:
Human   366 CIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 430

  Fly   885 FGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQIL 948
            |.::|.||.|.....||:||.|.:|.|.|..:|.||.:|: .|.:|:||......:|......|.
Human   431 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIF 495

  Fly   949 ANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWVA-----EEPRALLRAMS 1006
            .||:......:.:::.|.:|:||::.:.......  :....:.||..|.     .:...:||  :
Human   496 MNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLR--N 558

  Fly  1007 MTVC-DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDELPMMQVNFID 1069
            |..| |||..||..|:.::..|.:..|||:|||.|::. :.|:|   |..:....:...||.|||
Human   559 MVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP---MCDKHTASVEKSQVGFID 620

  Fly  1070 SICLPIYEAFATLSDKLEP----LVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNG 1130
            .|..|::|.:|   |.::|    :::.:.||| :|      .::...|...|..::|      |.
Human   621 YIVHPLWETWA---DLVQPDAQDILDTLEDNR-NW------YQSMIPQSPSPPLDEQ------NR 669

  Fly  1131 DCKAMSDDDVAASEAEVAVD-SPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQPSDDDNDVDA 1194
            ||:.:.:    ..:.|:.:| ..||.....|...:..||  .|.:.|..  ...:.|..:.|:|.
Human   670 DCQGLME----KFQFELTLDEEDSEGPEKEGEGHSYFSS--TKTLCVID--PENRDSLGETDIDI 726

  Fly  1195 DADD 1198
            ..:|
Human   727 ATED 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	20/97 (21%)
		GAF	611..762	CDD:214500	34/189 (18%)
		PDEase_I	859..1094	CDD:278654	74/248 (30%)
PDE4B	NP_001032418.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..78		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..209		0/19 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..301		5/26 (19%)
		PDEase_I	405..646	CDD:278654	74/248 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..736		12/50 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820