Protein Alignment Pde11 and PDE4A

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001104777.1
• Gene: PDE4A / 5141
• HGNCID: 8780
• Length: 886
• Species: Homo sapiens
• Alignment Length: 1044
• Identity: 202/1044 - (19%)
• Similarity: 349/1044 - (33%)
• Gaps: 355/1044 - (34%)

  Fly   352 SSLGSTG-GASGAGG------------APSLGGS--------------GGAGNGHQYPYYH---- 385
            ||...|| |:.||||            .||.|.|              |.|.:..:..:.:
Human    88 SSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDS 152

  Fly   386 -CHQRPQRLSRNE--LKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNA-----DRGSL 442
             ....|:.:|||.  ..:...::||      :....:|......:..|.|:|.|.     .|..|
Human   153 DYDMSPKTMSRNSSVTSEAHAEDLI------VTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPL 211

  Fly   443 FLVQGRCNGPDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQ 507
                   .||..:.|..:|:  :.|.:...|.:|:.|     |
Human   212 -------GGPTPVCKATLSE--ETCQQLARETLEELD-----W---------------------- 240

  Fly   508 DERFNC--EIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGI 570
                 |  :::::..||:                             .||:....|...|
Human   241 -----CLEQLETMQTYRS-----------------------------VSEMASHKFKRML----- 266

  Fly   571 GLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADK 635
               |.:|...|::....|||...::....::|:.:|
Human   267 ---NRELTHLSEMSRSGNQVSEYISTTFLDKQNEVE----------------------------- 299

  Fly   636 GSFSRVFDFEANDLSEEEATSRTSPYESRFP--------INIGITG-----HVATTGETVNVPNA 687
                    ..:..:.|.|......|..|:.|        ....|||     |..:...: |:|
Human   300 --------IPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNS-NIP-- 353

  Fly   688 YEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGM 752
                ||....|:      ..:|...::|           :||:              ...|||
Human   354 ----RFGVKTDQ------EELLAQELEN-----------LNKW--------------GLNIFC-- 381

  Fly   753 GIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDD 817
                                   |..|....::
Human   382 -----------------------VSDYAGGRSL-------------------------------- 391

  Fly   818 DTLKACL--RMFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTT 879
                .|:  .:|.:.|.:::|.|..:.:..::|:::.:|. :|.|||..||.:|.|....:|.|.
Human   392 ----TCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 452

  Fly   880 QWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSP 943
            ....:|.::|.||.:.....||:||.|.:|.|.|..:|.||.:|: .|.:|:||......:|...
Human   453 ALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED 517

  Fly   944 GNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWVA-----EEPRAL 1001
            ...|..|||......:.:::.|.:|:||::.:.......  :....:.||..|.     .:...:
Human   518 NCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQV 582

  Fly  1002 LRAMSMTVC-DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDELPMMQ 1064
            ||  :|..| |||..|||.|:.::..|.:.:|||:|||.|::. :.|:|   |..:....:...|
Human   583 LR--NMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISP---MCDKHTASVEKSQ 642

  Fly  1065 VNFIDSICLPIYEAFATL-SDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEE--------- 1119
            |.|||.|..|::|.:|.| ....:.:::.:.||| .|...|    .:.|....|||
Human   643 VGFIDYIVHPLWETWADLVHPDAQEILDTLEDNR-DWYYSA----IRQSPSPPPEEESRGPGHPP 702

  Fly  1120 -----------EQQQQNVISNGDCKAMSDDDVAA---SEAEVAVDSPSEKASVNGSNVANNSSNT 1170
                       |::::..||.......:.:.:.|   |..|.|:|          :.:|..:|..
Human   703 LPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALD----------ATIAWEASPA 757

  Fly  1171 NKKIAVASHPTSTQPSDDDNDVDADADDVDEQAAEENGHDAEVDEASCRSNSTCSSSTASSCLST 1235
            .:.:.|.:...|.       :.:.:|..:.:||..........||.|.|.....:.|.:|
Human   758 QESLEVMAQEASL-------EAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSS----- 810

  Fly  1236 PPPTGEDDSTPVSPL-KTLQAKLVAANL-----NALQRQTSNQAQTQKQRCKSCDHSRSGLQVRK 1294
              |:.....:|:.|. :||.....|..|     .|.:.:...:.|..|:.|.:|    :|.....
Human   811 --PSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSAC----AGTFGED 869

  Fly  1295 TSSL 1298
            ||:|
Human   870 TSAL 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	25/168 (15%)
		GAF	611..762	CDD:214500	21/163 (13%)
		PDEase_I	859..1093	CDD:459723	73/244 (30%)
PDE4A	NP_001104777.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..128		13/39 (33%)
		PDE4_UCR	178..293	CDD:465648	29/192 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..331		7/73 (10%)
		PDEase_I	432..672	CDD:459723	73/244 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..705		5/26 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	866..886		3/8 (38%)