Protein Alignment Pde11 and PDE3B

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001350499.1
• Gene: PDE3B / 5140
• HGNCID: 8779
• Length: 1190
• Species: Homo sapiens
• Alignment Length: 1020
• Identity: 202/1020 - (19%)
• Similarity: 343/1020 - (33%)
• Gaps: 323/1020 - (31%)

  Fly   306 SCSNLQNVGGVVAGQYQYNH-QQHHHNHAHLHHSQHSHY-QAGGAVGSSSLGSTGGASGAGGAPS 368
            ||.:|::       .:.|.| ..|..|...|......|. |||..:.:|....|..:..||
Human   365 SCLSLRS-------SWDYRHVPPHLANFVFLVEMGFLHVGQAGLELPTSGDLPTSASQSAG---- 418

  Fly   369 LGGSGGAGNGHQYPYYHCHQRPQRLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSI 433
            :.|:.|.|||                 .:|..|:|..   .:|.|:..:..:.......|:::|.
Human   419 ITGNSGGGNG-----------------VDLSVLNEAR---NMVSDLLTDPSLPPQVISSLRSISS 463

  Fly   434 LLNADRGSLFLVQGRCN---GP----DGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAG 491
            |:.|..||       |.   .|    .|...|           |.:|:
Human   464 LMGAFSGS-------CRPKINPLTPFPGFYPC-----------SEIED----------------- 493

  Fly   492 HVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSG--DVIGVAQVI--NKMNGEC 552
             .||.|          |.:.|      .|....:|....::.|||  .::.|.|..  ::.||:
Human   494 -PAEKG----------DRKLN------KGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGK- 540

  Fly   553 FSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQ 617
                     ..:.:|   |:.:...|    |....|..||.:.:   :..|::.      |||..
Human   541 ---------RPHQEF---GISSQGCY----LNGPFNSNLLTIPK---QRSSSVS------LTHHV 580

  Fly   618 SLIQCQRVQILLVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVA-----T 677
            .|   :|..:|       .|.|.|.......:|....|:| ||.|  ||.........:     :
Human   581 GL---RRAGVL-------SSLSPVNSSNHGPVSTGSLTNR-SPIE--FPDTADFLNKPSVILQRS 632

  Fly   678 TGETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLG-QIIGVIQLINKFNELDFTK---- 737
            .|...|.|:.|:..|   :.|.|.|            ||.| |::..:..    :|.|.|.
Human   633 LGNAPNTPDFYQQLR---NSDSNLC------------NSCGHQMLKYVST----SESDGTDCCSG 678

  Fly   738 ---NDENFV--EAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVP 797
               .:||..  |:|.:.      .|...|:     .::..:.::.........:||...::..:.
Human   679 KSGEEENIFSKESFKLM------ETQQEEE-----TEKKDSRKLFQEGDKWLTEEAQSEQQTNIE 732

  Fly   798 SAVHFRLHDFKFDDIHFEDDDTL---------------------------KACLRMFLDLDFVER 835
            ..|       ..|.|..|:.|:|                           :....:|.|...:|.
Human   733 QEV-------SLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEI 790

  Fly   836 FHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILT------------------TTQWW 882
            |.|..:....:..:::..||::.|||..||.:|...::.:.|                  |....
Human   791 FKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDG 855

  Fly   883 KI-------------------FG-------EIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQ 921
            :|                   :|       .:|.:||.:....||.||.|..|:|.:..::|.|.
Human   856 RINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAV 920

  Fly   922 LYS-TSTMEHHHFDQCL-MILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLE 984
            ||: .|.:|:||..... :.|:.|....|.:|...::.|...::.:|||:|||..:|.....|..
Human   921 LYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA 985

  Fly   985 SVSQPTS---YWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNI 1046
            ..:...|   .|..|..|.|:..:.:.:.|::...|..::..:..:.:.:||:||||   :|.|:
Human   986 KANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGD---EEANL 1047

  Fly  1047 -TPIDIMNREKEDELPMMQVNFIDSICLPI---YEAFATLSDKLEPLVEGVRDNRGHWIDLADVV 1107
             .||.........:|..:|.:||..|..|:   |:|...|.              |.|::..:..
Human  1048 GLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLP--------------GQWLEAEEDN 1098

  Fly  1108 KTKTSQDQEPEEEQQQQNVISNG--------------DCKAMSDDDVAASE-----AEVAVDSPS 1153
            .|::..|::.||...:...:.|.              .|:.|..    .:|     .|:..:...
Human  1099 DTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHH----LTENHKIWKEIVEEEEK 1159

  Fly  1154 EKASVNGSNVANNSSNTNKKIAVASHPTSTQPSDDDNDVDADADD 1198
            .||..|...|.|                |:.|..|:..|..:||:
Human  1160 CKADGNKLQVEN----------------SSLPQADEIQVIEEADE 1188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	29/172 (17%)
		GAF	611..762	CDD:214500	37/165 (22%)
		PDEase_I	859..1094	CDD:278654	67/287 (23%)
PDE3B	NP_001350499.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		Interaction with RAPGEF3. /evidence=ECO:0000269|PubMed:21393242	1..25
		DUF1109	136..>282	CDD:310850
		PDEase_I	814..1088	CDD:306695	66/276 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154155
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850