Protein Alignment Pde11 and PDE3A

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_000912.3
• Gene: PDE3A / 5139
• HGNCID: 8778
• Length: 1141
• Species: Homo sapiens
• Alignment Length: 925
• Identity: 185/925 - (20%)
• Similarity: 303/925 - (32%)
• Gaps: 302/925 - (32%)

  Fly   372 SGGAGNGHQYPYYHCHQRPQRLSRNELKQLDEKE------------------------LIFELVK 412
            ||.:...|:.....|..|.|.:..:|   .|.|.                        ||.:|:.
Human   301 SGCSSKSHRRTSLPCIPREQLMGHSE---WDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLA 362

  Fly   413 D------ICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKKCLVSKLFDVCPRST 471
            |      :|..|..          ||.||:.......:.:.|.|.        |:.|.:....|.
Human   363 DPSLPPNVCTSLRA----------VSNLLSTQLTFQAIHKPRVNP--------VTSLSENYTCSD 409

  Fly   472 VEEMEQQDEVRV------------------AWGTGIAGHVAESGEPVNI-------------PDA 505
            .||..::|::.:                  .|.|..:.....:.||..:             |.:
Human   410 SEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSS 474

  Fly   506 YQDERFNCEIDSLT-------GYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSS 563
            ..|...|..:.:||       .|...|...:..|..|..  |....|:.::..|.|.:.....||
Human   475 SPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRP--GALAKISPLSSPCSSPLQGTPASS 537

  Fly   564 YLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQIL 628
            .:.    .:...|..|.:....|               ||...|   |.||:.||
Human   538 LVS----KISAVQFPESADTTAK---------------QSLGSH---RALTYTQS---------- 570

  Fly   629 LVHEADKGSFSRVFDFEANDLSEEEAT------SRTSPYESRFPINIGI-TGHVAT-----TGET 681
                             |.|||.:..|      |...||....|.:..: ...|||     |.:|
Human   571 -----------------APDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDT 618

  Fly   682 VNVPNAYE-DDRFDAS-----VDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDE 740
            ..|.:.|| ::..|:|     .||..|.:                                   |
Human   619 AQVTSDYETNNNSDSSDIVQNEDETECLR-----------------------------------E 648

  Fly   741 NFVEAFAIFCGMGIHNTHMY-EKAIVA-----MAKQSVTLEVLSYHASATMDEAHRLRRL--RVP 797
            ...:|.|  |......|.|: :|.|:|     |......:|.|:.......|....:.|.  |:.
Human   649 PLRKASA--CSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRIL 711

  Fly   798 SAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNW 862
            |.|.:||                      |.|:...|.|.|.......:..:::..||::.|||.
Human   712 SQVSYRL----------------------FEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNR 754

  Fly   863 RHAFNVAQMMFAI-----------------------------------------LTTTQWWKIFG 886
            .||.:|...::.:                                         :|..::..:.|
Human   755 IHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSG 819

  Fly   887 EI---ECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCL-MILNSPGNQ 946
            .|   |.:||.:....||.||.|..|:|.:..|:|.|.||: .|.:|:||..... :.::.|...
Human   820 NIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYN 884

  Fly   947 ILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSY-WVAEEPRALLRAMSMTVC 1010
            .|.||...::.....::.:|||:|||..:|.....|...|:..... |..|..|.|:..|.:.:.
Human   885 FLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLA 949

  Fly  1011 DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPI 1075
            |::...|..|:..:..|.:.:||:|||| |:..|.: ||.........:|..:|.:||..|..|:
Human   950 DINGPAKCKELHLQWTDGIVNEFYEQGD-EEASLGL-PISPFMDRSAPQLANLQESFISHIVGPL 1012

  Fly  1076 YEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCKAMSDDDV 1140
            ..::.  |..|.|         |.|::.:|    ::....:||||::        :..|.::::.
Human  1013 CNSYD--SAGLMP---------GKWVEDSD----ESGDTDDPEEEEE--------EAPAPNEEET 1054

  Fly  1141 AASEAEVAVDSPSEK 1155
            ..:.     :||.:|
Human  1055 CENN-----ESPKKK 1064

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	33/199 (17%)
		GAF	611..762	CDD:214500	33/169 (20%)
		PDEase_I	859..1093	CDD:459723	69/280 (25%)
PDE3A	NP_000912.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..482		6/45 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	590..640		13/49 (27%)
		Interaction with SLFN12. /evidence=ECO:0000269|PubMed:35104454	669..1141		100/448 (22%)
		PDEase_I	751..1012	CDD:459723	65/262 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1023..1062		10/64 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1100..1141