DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde11 and PDE3A

DIOPT Version :9

Sequence 1:NP_001286044.1 Gene:Pde11 / 35107 FlyBaseID:FBgn0085370 Length:1451 Species:Drosophila melanogaster
Sequence 2:NP_000912.3 Gene:PDE3A / 5139 HGNCID:8778 Length:1141 Species:Homo sapiens


Alignment Length:925 Identity:185/925 - (20%)
Similarity:303/925 - (32%) Gaps:302/925 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   372 SGGAGNGHQYPYYHCHQRPQRLSRNELKQLDEKE------------------------LIFELVK 412
            ||.:...|:.....|..|.|.:..:|   .|.|.                        ||.:|:.
Human   301 SGCSSKSHRRTSLPCIPREQLMGHSE---WDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLA 362

  Fly   413 D------ICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKKCLVSKLFDVCPRST 471
            |      :|..|..          ||.||:.......:.:.|.|.        |:.|.:....|.
Human   363 DPSLPPNVCTSLRA----------VSNLLSTQLTFQAIHKPRVNP--------VTSLSENYTCSD 409

  Fly   472 VEEMEQQDEVRV------------------AWGTGIAGHVAESGEPVNI-------------PDA 505
            .||..::|::.:                  .|.|..:.....:.||..:             |.:
Human   410 SEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSS 474

  Fly   506 YQDERFNCEIDSLT-------GYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSS 563
            ..|...|..:.:||       .|...|...:..|..|..  |....|:.::..|.|.:.....||
Human   475 SPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRP--GALAKISPLSSPCSSPLQGTPASS 537

  Fly   564 YLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQIL 628
            .:.    .:...|..|.:....|               ||...|   |.||:.||          
Human   538 LVS----KISAVQFPESADTTAK---------------QSLGSH---RALTYTQS---------- 570

  Fly   629 LVHEADKGSFSRVFDFEANDLSEEEAT------SRTSPYESRFPINIGI-TGHVAT-----TGET 681
                             |.|||.:..|      |...||....|.:..: ...|||     |.:|
Human   571 -----------------APDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDT 618

  Fly   682 VNVPNAYE-DDRFDAS-----VDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDE 740
            ..|.:.|| ::..|:|     .||..|.:                                   |
Human   619 AQVTSDYETNNNSDSSDIVQNEDETECLR-----------------------------------E 648

  Fly   741 NFVEAFAIFCGMGIHNTHMY-EKAIVA-----MAKQSVTLEVLSYHASATMDEAHRLRRL--RVP 797
            ...:|.|  |......|.|: :|.|:|     |......:|.|:.......|....:.|.  |:.
Human   649 PLRKASA--CSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRIL 711

  Fly   798 SAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNW 862
            |.|.:||                      |.|:...|.|.|.......:..:::..||::.|||.
Human   712 SQVSYRL----------------------FEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNR 754

  Fly   863 RHAFNVAQMMFAI-----------------------------------------LTTTQWWKIFG 886
            .||.:|...::.:                                         :|..::..:.|
Human   755 IHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSG 819

  Fly   887 EI---ECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCL-MILNSPGNQ 946
            .|   |.:||.:....||.||.|..|:|.:..|:|.|.||: .|.:|:||..... :.::.|...
Human   820 NIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYN 884

  Fly   947 ILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSY-WVAEEPRALLRAMSMTVC 1010
            .|.||...::.....::.:|||:|||..:|.....|...|:..... |..|..|.|:..|.:.:.
Human   885 FLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLA 949

  Fly  1011 DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPI 1075
            |::...|..|:..:..|.:.:||:|||| |:..|.: ||.........:|..:|.:||..|..|:
Human   950 DINGPAKCKELHLQWTDGIVNEFYEQGD-EEASLGL-PISPFMDRSAPQLANLQESFISHIVGPL 1012

  Fly  1076 YEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCKAMSDDDV 1140
            ..::.  |..|.|         |.|::.:|    ::....:||||::        :..|.::::.
Human  1013 CNSYD--SAGLMP---------GKWVEDSD----ESGDTDDPEEEEE--------EAPAPNEEET 1054

  Fly  1141 AASEAEVAVDSPSEK 1155
            ..:.     :||.:|
Human  1055 CENN-----ESPKKK 1064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde11NP_001286044.1 GAF 420..582 CDD:214500 33/199 (17%)
GAF 611..762 CDD:214500 33/169 (20%)
PDEase_I 859..1094 CDD:278654 69/281 (25%)
PDE3ANP_000912.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..42
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 436..482 6/45 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 590..640 13/49 (27%)
PDEase_I 751..1012 CDD:306695 65/262 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1023..1062 10/64 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1100..1141
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154150
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D904682at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

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