DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde11 and PDE2A

DIOPT Version :9

Sequence 1:NP_001286044.1 Gene:Pde11 / 35107 FlyBaseID:FBgn0085370 Length:1451 Species:Drosophila melanogaster
Sequence 2:NP_002590.1 Gene:PDE2A / 5138 HGNCID:8777 Length:941 Species:Homo sapiens


Alignment Length:762 Identity:246/762 - (32%)
Similarity:390/762 - (51%) Gaps:69/762 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   411 VKDICNE---LEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLK-KCLVSKLFDVCPRST 471
            :..:|.|   |:..:|..|:||.:.....|.|..|.||     ..|.|: .|.|           
Human   230 ILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLV-----SEDNLQLSCKV----------- 278

  Fly   472 VEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSG 536
            :.:....:||.... ||..|.|.|..:.:.:.|...::  ..::.|:.|...:|:||:|:...:.
Human   279 IGDKVLGEEVSFPL-TGCLGQVVEDKKSIQLKDLTSED--VQQLQSMLGCELQAMLCVPVISRAT 340

  Fly   537 D-VIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFE 600
            | |:.:|...||:.|:.|::.||.|......:....|.:...::|.|......|.||.:|:.:|.
Human   341 DQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFT 405

  Fly   601 EQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRF 665
            ....:..::..|:|..::|...:...:.|:.:.:  ..::|||   ..:.::|:      ||.|.
Human   406 HLDDVSVLLQEIITEARNLSNAEICSVFLLDQNE--LVAKVFD---GGVVDDES------YEIRI 459

  Fly   666 PINIGITGHVATTGETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKF 730
            |.:.||.|||||||:.:|:|:||....|...||:::.|:.|:|||..|||...::|||.:|:||.
Human   460 PADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKI 524

  Fly   731 NELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRR-- 793
            |...|:|.||:...||:|:||:.|.::.:|:|...|..:..:..|::.||...:.||..:|..  
Human   525 NGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDG 589

  Fly   794 LRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVT 858
            ::..:|:......|.:......:|||..|.|.|..|::|:..:.||...|.|:.|.|||.||:..
Human   590 IQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPP 654

  Fly   859 YHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLY 923
            ||||.|||:|:...:.:....:......:||..||.|.|:||||||||||||||:.:.|.||.||
Human   655 YHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALY 719

  Fly   924 ST--STMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVY---FKKRGPFL 983
            |:  |.||.|||.|.:.|||:.|..|..:.|..||.|::.::.|.||:||||.:   ||.    |
Human   720 SSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKD----L 780

  Fly   984 ESVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITP 1048
            :.:::.......::...||..:.||.||||..||.|:..:::|:|:..|||.|||:||...| .|
Human   781 QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGN-RP 844

  Fly  1049 IDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQ 1113
            :::|:|||. .:|.:|::|::.|.:|||:....|..|...|.|.|..||.||        ||.| 
Human   845 MEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHW--------TKVS- 899

  Fly  1114 DQEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDSPSEKASVNG 1160
                 .:...:.:.||...      |....|.||. |....:|.:||
Human   900 -----HKFTIRGLPSNNSL------DFLDEEYEVP-DLDGTRAPING 934

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde11NP_001286044.1 GAF 420..582 CDD:214500 39/163 (24%)
GAF 611..762 CDD:214500 54/150 (36%)
PDEase_I 859..1094 CDD:278654 98/239 (41%)
PDE2ANP_002590.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 16..42
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 196..221
GAF 241..387 CDD:214500 39/164 (24%)
GAF 409..558 CDD:214500 55/159 (35%)
PDEase_I 655..885 CDD:306695 96/235 (41%)
Substrate binding 656..660 3/3 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154151
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D114875at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.750

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