Protein Alignment Pde11 and PDE1C

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_016867753.1
• Gene: PDE1C / 5137
• HGNCID: 8776
• Length: 804
• Species: Homo sapiens
• Alignment Length: 684
• Identity: 163/684 - (23%)
• Similarity: 269/684 - (39%)
• Gaps: 152/684 - (22%)

  Fly   629 LVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRF 693
            ||.:.::|..| |.|.:.|  .|..||...|.|             :..|...::..:...|.:.
Human   142 LVKQLERGEAS-VVDLKKN--LEYAATVLESVY-------------IDETRRLLDTEDELSDIQS 190

  Fly   694 DASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTH 758
            ||...|     .|..|.......:|      .::.:.:|....|:..:.|:|       ||....
Human   191 DAVPSE-----VRDWLASTFTRQMG------MMLRRSDEKPRFKSIVHAVQA-------GIFVER 237

  Fly   759 MYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHD---FKFDDIHFED---D 817
            ||        :::..:..|||                 |.||...|.|   :.||.....:   |
Human   238 MY--------RRTSNMVGLSY-----------------PPAVIEALKDVDKWSFDVFSLNEASGD 277

  Fly   818 DTLKACLRMFLDL----DFVERFHIDYEVLCRWLLSVKKNY---RNVTYHNWRHAFNVAQMMFAI 875
            ..||.   :|.:|    |.:.||.|....|..::.:::..|   :| .|||..||.:|.|.:..:
Human   278 HALKF---IFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKN-PYHNLMHAADVTQTVHYL 338

  Fly   876 LTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMI 939
            |..|.......|:|..|:|.....||.:|.||.|:|.|:..|..|.||: .|.:|:||......:
Human   339 LYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRL 403

  Fly   940 LNSPGN-QILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEPRALLR 1003
            |..... .||.|||.||:.....::.:.:::||::.:|::......::.||.:   .|:|:||
Human   404 LQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA---IEKPKAL-- 463

  Fly  1004 AMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFI 1068
            ::.:...|:|...|.|::..|....:..|||.|||.| .||.: |...:...|...:...||.||
Human   464 SLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDRE-AELGL-PFSPLCDRKSTMVAQSQVGFI 526

  Fly  1069 DSICLPIYEAFATLSDKL-EPLVE--------GVRDNRGHWIDLADV----VKTKTSQDQEP--- 1117
            |.|..|.:.....:::|: .||::        |.|.:..:.|..:|.    |||..|:...|
Human   527 DFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKRSGVKTSGSEGSAPINN 591

  Fly  1118 ------------------------------------EEEQQQQNVISNGDCKAMSDDDVAASEAE 1146
                                                :|.:::..:.:....|.|.    |.|:||
Human   592 SVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEQQKEME----AKSQAE 652

  Fly  1147 VAVDSPSEKAS-------VNGSNVANNSSNTNKKIAVASHPTSTQPSDDDNDVDADADDVDEQAA 1204
            ......:||.:       |||:. ||.|.|...|.:.|...:..|  ..:.|.....:..|::..
Human   653 EGASGKAEKKTSGETKNQVNGTR-ANKSDNPRGKNSKAEKSSGEQ--QQNGDFKDGKNKTDKKDH 714

  Fly  1205 EENGHDA-EVDEASCRSNSTCSSSTASSCLSTPP 1237
            ...|:|: :.|....||:.:.:.||:|:|..|.|
Human   715 SNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLP 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	28/132 (21%)
		PDEase_I	859..1093	CDD:459723	72/244 (30%)
PDE1C	XP_016867753.1	PDEase_I_N	177..237	CDD:462497	13/77 (17%)
		PDEase_I	322..550	CDD:459723	72/234 (31%)