DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and PDE11A

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_058649.3	Gene:	PDE11A / 50940	HGNCID:	8773	Length:	933	Species:	Homo sapiens

Alignment Length:	945	Identity:	400/945 - (42%)
Similarity:	557/945 - (58%)	Gaps:	79/945 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 EHARMEAWLDENQEFVQDYFIRKATRQTVDAWLVSHATSAG-----NDVVSSTSPTHANGQTSSS 254
            :...:|.:||.:.|..:||.:||..::.|:.||..|:...|     ..:..::|..|     |:.
Human     7 DFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSSLAH-----STC 66

  Fly   255 RGGS---GATTPVRKISAHEFERGGLLKPIVNTIDGTPTFLSIGPPMDNGSVGGSCSNLQNVGGV 316
            ||||   |.|.|.....:.....||       ...|.|    :.|....||.|.  .|||.
Human    67 RGGSSVGGGTGPNGSAHSQPLPGGG-------DCGGVP----LSPSWAGGSRGD--GNLQR---- 114

  Fly   317 VAGQYQYNHQQHHHNHAHLHHSQHSHYQAGGAVGSSSLGSTGGASGAGGAPSLGGSGGAGNGH-- 379
            .|.|.:...........|::.:......:......||:........|...|..       ..|
Human   115 RASQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPT-------TAHIL 172

  Fly   380 -----------QYP----YYHCHQRPQRLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQ 429
                       :||    .|.||          ||:.:|::...||||||.|:|::.:|.:|||.
Human   173 SALLESRVNLPRYPPTAIDYKCH----------LKKHNERQFFLELVKDISNDLDLTSLSYKILI 227

  Fly   430 NVSILLNADRGSLFLVQGRCNGPDGLKKCLVSKLFDV---CPRSTVEEMEQQDEVRVAWGTGIAG 491
            .|.::::|||.|||||:|...|    ||.||||.|||   .|.......|..:||:|.||.||.|
Human   228 FVCLMVDADRCSLFLVEGAAAG----KKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIG 288

  Fly   492 HVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKM-NGECFSE 555
            :|.|.||.|||||||||.|||.|||.||||:||:||||||:.|.|::|||||.|||: .|..|:|
Human   289 YVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTE 353

  Fly   556 IDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLI 620
            .||||...||.||||.:.||||:..|:.|.:|::.||::...:||||:.:|.:|.:|:...|:|:
Human   354 DDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL 418

  Fly   621 QCQRVQILLVHEADKG--SFSRVFDFEANDLSEEEATSRTSPYE----SRFPINIGITGHVATTG 679
            :|:|..:||:.:.:..  .|::.|:..:...|.:...|.....|    |.:.||..|...||:||
Human   419 KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTG 483

  Fly   680 ETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVE 744
            ..||:.:||:|.||||..|:.|.|..||:||:.|.||..|||||.|::|:.:...|...|:...|
Human   484 LPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFE 548

  Fly   745 AFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKF 809
            ||.||||:||:||.||::...:.|||||.|:||||||:.:..|..:.:...:|......:.|..|
Human   549 AFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHF 613

  Fly   810 DDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFA 874
            ||...:.|..:.|.||||::|..|::|.||||.||||||:|:||||.|.||||||||||.|:|||
Human   614 DDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFA 678

  Fly   875 ILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYSTS-TMEHHHFDQCLM 938
            :|||..:..|..|:|.||:|:||||||||||||||:||.|:.|.|||||.|| |:|||||:..:|
Human   679 MLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVM 743

  Fly   939 ILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEPRALLR 1003
            ||.|.|:.|.|||||.:|..::::|:.:||:|||.:||::|..|.|.||:....|..:..|.:.|
Human   744 ILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFR 808

  Fly  1004 AMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFI 1068
            :|.||.|||.|:||||||.::||:||:||||||||.|:.||.:||..|.:|.::||||.:|:.:|
Human   809 SMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWI 873

  Fly  1069 DSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDL 1103
            ||||:|:|:|...::.||:|:::.|..||..|.:|
Human   874 DSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	92/165 (56%)
		GAF	611..762	CDD:214500	61/156 (39%)
		PDEase_I	859..1094	CDD:278654	130/235 (55%)
PDE11A	NP_058649.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..125		25/104 (24%)
		GAF	217..380	CDD:214500	92/166 (55%)
		GAF	402..568	CDD:214500	63/165 (38%)
		PDEase_I	663..898	CDD:278654	130/234 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154148
Domainoid	1	1.000	280	1.000	Domainoid score	I1685
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	1	1.000	-	-		FOG0002593
OrthoInspector	1	1.000	-	-		otm40818
orthoMCL	1	0.900	-	-		OOG6_100960
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.650