DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and Pde3a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_059033.1	Gene:	Pde3a / 50678	RGDID:	61942	Length:	1141	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	150/745 - (20%)
Similarity:	251/745 - (33%)	Gaps:	224/745 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   571 GLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADK 635
            |:.:.|..|..::..||...               .|   |.||:.||
  Rat   541 GIASVQFPESPEVTTKRGPG---------------SH---RALTYTQS----------------- 570

  Fly   636 GSFSRVFDFEANDLSEE------EATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFD 694
                      |.|||.:      ..:|...||....|.:    |....:|..:..||..:|
  Rat   571 ----------APDLSPQIPPSPVICSSCGRPYSQGNPAD----GPSERSGPAMQKPNRTDD---- 617

  Fly   695 ASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEA--------FAIFCG 751
                                  ..|:....:..|..:..|..:|||   ||        .|..||
  Rat   618 ----------------------TSQVTSDYETNNNSDSSDILQNDE---EAECQREPLRKASACG 657

  Fly   752 MGIHNTHMY-EKAIVA-----MAKQSVTLEVLSYHASATMDEAHRLRRL--RVPSAVHFRLHDFK 808
            .....|.:: :|.|:|     |......::.|:.......|....:.|.  |:.|.|.:||
  Rat   658 TYTPQTMIFLDKPILAPEPLVMDNLDSIMDQLNTWNFPIFDLVENIGRKCGRILSQVSYRL---- 718

  Fly   809 FDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMF 873
                              |.|:...|.|.|.......:..:::..||::.|||..||.:|...::
  Rat   719 ------------------FEDMGLFEAFKIPVREFMNYFHALEIGYRDIPYHNRIHATDVLHAVW 765

  Fly   874 AILTTTQ----------------------------WWKIFGE------------------IECLA 892
            .:  |||                            ...:|.:                  :|.:|
  Rat   766 YL--TTQPIPGLPSVIGDHGSASDSDSDSGFTHGHMGYVFSKAYHVPDDKYGCLSGNIPALELMA 828

  Fly   893 LIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCL-MILNSPGNQILANLSSDD 955
            |.:....||.||.|..|:|.:..|:|.|.||: .|.:|:||..... :.::.|....|.||...:
  Rat   829 LYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVE 893

  Fly   956 YCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSY-WVAEEPRALLRAMSMTVCDLSAITKPW 1019
            :.....::.:|||:|||..:|.....|...|:..... |..|..|.|:..|.:.:.|::...|..
  Rat   894 FKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCK 958

  Fly  1020 EIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSD 1084
            ::..|..:.::|||:|||| |:..|.: ||.........:|..:|.:||..|..|:..::.  |.
  Rat   959 DLHLRWTEGIASEFYEQGD-EEASLGL-PISPFMDRSAPQLANLQESFISHIVGPLCHSYD--SA 1019

  Fly  1085 KLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAV 1149
            .|.|         |.|:|.:|    .:....:||||::                     |||
  Rat  1020 GLMP---------GKWVDDSD----DSGDTDDPEEEEE---------------------EAE--- 1047

  Fly  1150 DSPSEKASVNGSNVANNSSNTNKKI-------AVASHPTSTQPSDDDNDVDADADDVDEQAAEEN 1207
             :|.|:.:...|......|...::|       .:.:|....:..:::..:....:...:||..:
  Rat  1048 -TPHEEETCENSEAPRKKSFKRRRIYCQITQHLLQNHMMWKKVIEEEQCLSGTENQAPDQAPLQ- 1110

  Fly  1208 GHDAEVDEASCRSNSTCSSSTASSCLSTPP 1237
             |.:|..:|............|...|:..|
  Rat  1111 -HSSEQIQAIKEEEEEKGKPRAEETLAPQP 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	3/10 (30%)
		GAF	611..762	CDD:214500	30/165 (18%)
		PDEase_I	859..1094	CDD:278654	70/283 (25%)
Pde3a	NP_059033.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..309
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..479
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..643		30/179 (17%)
		PDEase_I	751..1012	CDD:278654	66/264 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1062		14/66 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1098..1141		8/44 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347763
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850