Protein Alignment Pde11 and Pde6

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Alignment Length: 1268
• Identity: 457/1268 - (36%)
• Similarity: 636/1268 - (50%)
• Gaps: 253/1268 - (19%)

  Fly   126 PAHYQPLNHSGAAPPSSS------NGS-----SSSGGGVQTSATP---------QQQQQYQVQQP 170
            |......:.|.||..|:|      ||:     |::.|||...|.|         ......||:
  Fly    14 PVEMSTTSSSSAATTSASSSKPLTNGANKTAISTAAGGVTPGAVPGPGSGAIPASSSSGNQVK-- 76

  Fly   171 YQYQYQHHYHHQANSPQHHRPYDPEHARMEAWLDENQEFVQDYFIRKATRQTVDAWLVSHATSAG 235
                 ..|:|.|:|   ::||                         ..|.::.:..|:: .|.:.
  Fly    77 -----LEHHHRQSN---NNRP-------------------------AVTNRSSETKLMT-PTGSS 107

  Fly   236 NDVVSSTSPTHANGQTSSSRGG--SGATTPVRKISAHEFERGGLLKPIVNTIDGTPTFLSIGPPM 298
            :....|.|.|.|:.||.:|:..  :.|:|...:....|..|....||     :....:|:...|.
  Fly   108 SSPSQSPSQTQASIQTQTSQQDRLAKASTTASQQDVDEVARLFEEKP-----EAFEKWLTERAPP 167

  Fly   299 DNGSVGGSCSNLQNVGGVVAGQYQYNHQQHHHNHAHLHHSQHSHYQAGGAVGSSSLGSTGGASGA 363
            :      :.|.||          ::...:..|....:.......:.|...........:...|.|
  Fly   168 E------ALSRLQ----------EFIENRKPHKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSA 216

  Fly   364 GGAPSLGGSGGAGNGHQYPYYHCHQRPQRLSRNELKQLDEKELIFELVKDICNELEVRTLCHKIL 428
            ...|                 .|        |..|..|||.||..||::|:.|||::..||||||
  Fly   217 SSLP-----------------EC--------RRHLMDLDEGELFMELIRDVANELDIDVLCHKIL 256

  Fly   429 QNVSILLNADRGSLFLVQGRCNGPDGLKKCLVSKLFDVCPRSTVEE---MEQQDEVRVAWGTGIA 490
            .||.:|.:||||||||.:|     ....|.||:|||||..::.:::   ....:|:.:.:|.|||
  Fly   257 VNVGLLTHADRGSLFLAKG-----TPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIA 316

  Fly   491 GHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGEC--F 553
            |.||::.:.:||.:||:|.|||||||..|||:|.|:|||||.:..||:|||||:|||.|| |  |
  Fly   317 GMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNG-CMEF 380

  Fly   554 SEIDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQS 618
            .|.|.::|..||.|||||::||||:|.|..|.:|||:||:|||.|||||:.:|.:|.:|:|..:.
  Fly   381 DEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARE 445

  Fly   619 LIQCQRVQILLV-------------------------HEAD-------KGSFSRVF----DFEAN 647
            |::|:|..:.||                         ..||       :..|:.:|    :::|.
  Fly   446 LLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAA 510

  Fly   648 DLSE---EEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYE----------DDRFDASVDE 699
            ::|.   .|.:|.|....::|         |||||:|||:.:..|          :|..|::
  Fly   511 NVSRPSVSELSSSTLAQIAQF---------VATTGQTVNICDVIEWVRDHNQIRAEDEIDST--- 563

  Fly   700 NSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAI 764
                  ::||||.|.|:..::|||.|||||.|.:.||.:|.:..||||||||:|||||.|||.|.
  Fly   564 ------QAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENAC 622

  Fly   765 VAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLD 829
            ..||||.|.||.|||||:|:.|:..:|.:..:..|..:.|:.|.|.|....||||.:|.||||:.
  Fly   623 KLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAVLRMFMQ 687

  Fly   830 LDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALI 894
            .:.|.:|.|.|:|||||:|||:||||.|.|||||||.||||.|||:|.|.:..:...::|.|.|:
  Fly   688 CNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLL 752

  Fly   895 IGCLCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRV 959
            :.|||||||||||||:||.|..||||.||:||||||||||||:|||||.||.|...||.:||..|
  Fly   753 VACLCHDLDHRGTNNAFQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSV 817

  Fly   960 IRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKR 1024
            ::.:|.||||||||:|||||..|||.|......|..||.:.||..|.||.||:|||.||||::.:
  Fly   818 MKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHK 882

  Fly  1025 VADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPL 1089
            ||.||:.|||:|||:||.:||..|:.:|:||::||||.|||.|||.||||:|.........:.||
  Fly   883 VAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPL 947

  Fly  1090 VEGVRDNRGHWIDLADVVK---TKTSQD--QEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAV 1149
            .||..:||.:|.|||:.|:   |....|  .:|.||           ..|.:|:::...|..|..
  Fly   948 YEGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPVEE-----------FAACADEEIKDIEFTVTT 1001

  Fly  1150 ------------DSPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQPSDDDNDVDADADDVDEQ 1202
                        ||.:.:...:||.::...:....| ||.|..:.|..:..|..
  Fly  1002 LNCNQQSQHGSEDSHTPEHQRSGSRLSMKKTGALGK-AVRSKLSKTLYNSMDGS----------- 1054

  Fly  1203 AAEENGHDAEVDEASCRSNSTCSSSTASSCLSTPPPTGEDDSTPVSPLKTLQAKLVAANLNALQR 1267
                                  ...|:...|.:......||.:|.||.:. ||......::|...
  Fly  1055 ----------------------KPKTSLKLLESHVSEDMDDKSPTSPSQP-QASGSMGRMSASSS 1096

  Fly  1268 QTSNQAQ---TQKQRCKSCDHSRSGLQVRKTSS 1297
            .:|...|   ..|:|.|.|     .|. ||.|:
  Fly  1097 TSSAGGQMVDKSKKRSKLC-----ALLXRKPSN 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	85/166 (51%)
		GAF	611..762	CDD:214500	61/199 (31%)
		PDEase_I	859..1094	CDD:278654	138/234 (59%)
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	84/164 (51%)
		GAF	431..619	CDD:214500	62/205 (30%)
		PDEase_I	717..950	CDD:278654	136/232 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	216	1.000	Domainoid score	I1562
eggNOG	1	0.900	-	-		E1_KOG3689
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	1	1.000	-	-		FOG0002593
OrthoInspector	1	1.000	-	-		mtm6603
orthoMCL	1	0.900	-	-		OOG6_100960
Panther	1	1.100	-	-	P	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.820