Protein Alignment Pde11 and pde10a

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_957396.2
• Gene: pde10a / 394077
• ZFINID: ZDB-GENE-040426-1115
• Length: 794
• Species: Danio rerio
• Alignment Length: 764
• Identity: 252/764 - (32%)
• Similarity: 398/764 - (52%)
• Gaps: 77/764 - (10%)

  Fly   402 DEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNG------PDGLKKCLV 460
            |.|.|::||    ||.::..|             .||..:|:.: |.||.      |.|.|:.|.
Zfish   101 DNKLLLYEL----CNIIKTAT-------------KADGFALYFL-GECNNSLCLFTPTGAKEGLP 147

  Fly   461 SKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKA 525
            .    :.|...           :.:||.||.|||::.:.:.:.|...||||.......:|.|..:
Zfish   148 G----LIPSGP-----------ITFGTTIAAHVAKTRKTLLVEDIMGDERFPHGTGQDSGIRVHS 197

  Fly   526 LLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQV 590
            :||:||..:.||:|.:.::...:..|.|:...::|.::.|.:..:.:...|:......:.:.|..
Zfish   198 VLCLPILTAIGDLIAILELHRHLGREPFNLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDF 262

  Fly   591 LLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFEANDLSEEEAT 655
            |||:::..|:....|:.::..|:.:.::|:...|..:..|...:|..:|.:||.  .:.:|.:..
Zfish   263 LLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHNNKELYSDLFDI--GEENEGKPV 325

  Fly   656 SRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQI 720
            .|.:. |.||.|..||.|.||.|||.:|:|:||.|.||:..||..:.:..|:||||.|. |.|.:
Zfish   326 FRKTK-EIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV-SRGTV 388

  Fly   721 IGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATM 785
            |||:|::||.....|||.|||..:.||:||.:.:|..:||.:...:.....||:|.||||:..|.
Zfish   389 IGVVQMVNKLGGSAFTKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTS 453

  Fly   786 DEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSV 850
            :|...|.:|.:|||::..:..|.||...||:   |...:.:::..:...:...:.|.|||:.:||
Zfish   454 EEWKTLTQLTLPSAIYKEIELFHFDIAPFEE---LWPAIFVYMVHNSCGKTSFELEKLCRFTMSV 515

  Fly   851 KKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKA 915
            :||||.|.||||:||..||..|:|||..|.  .||.|:|...|:|.||||||||||.:||:..|.
Zfish   516 RKNYRRVPYHNWKHAVTVAHCMYAILQKTT--GIFTELERKGLLIACLCHDLDHRGYSNSYLQKF 578

  Fly   916 SSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRG 980
            ..|||.||||||||.|||.|.:.||.. |:.|.:||:|.:|.:|:.::..||::||||:||..|.
Zfish   579 DHPLAALYSTSTMEQHHFSQTVSILQE-GHNIFSNLTSGEYEQVLEIIRKAIIATDLALYFGNRK 642

  Fly   981 PFLESVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELN 1045
            ...|.:|...........|..:..:.||.|||.::||.|.:.:..|:.:.:||:.:|| |.:::.
Zfish   643 QLAELLSTGALDLNNRAHRDRVIGLMMTACDLCSVTKLWPVTRLTANDIYAEFWAEGD-EMKKIG 706

  Fly  1046 ITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTK 1110
            :.||.:|:|:|:||:|..||.|.:::.:|.|...:.|.....||:|..|:|...|
Zfish   707 MQPISMMDRDKKDEVPQGQVGFYNAVAIPCYTTLSELFPPSVPLLEACRENLSQW---------- 761

  Fly  1111 TSQDQEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDSPSEKASVN 1159
                         :.::...|..|.|    :..||||:..|.|....|:
Zfish   762 -------------ERIVQGEDVSAWS----STEEAEVSETSDSGPVKVD 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	38/167 (23%)
		GAF	611..762	CDD:214500	58/150 (39%)
		PDEase_I	859..1093	CDD:459723	99/233 (42%)
pde10a	NP_957396.2	GAF	<39..>259	CDD:441805	45/190 (24%)
		GAF	277..432	CDD:214500	59/158 (37%)
		PDEase_I	524..754	CDD:459723	99/233 (42%)