Protein Alignment Pde11 and pde6a

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001007161.1
• Gene: pde6a / 368410
• ZFINID: ZDB-GENE-030616-42
• Length: 858
• Species: Danio rerio
• Alignment Length: 803
• Identity: 251/803 - (31%)
• Similarity: 423/803 - (52%)
• Gaps: 73/803 - (9%)

  Fly   394 SRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKKC 458
            |.:||..::|.|:||::|:|:...|.:......:::::|.::.|||.|||:.:.|    :|:.:
Zfish    49 SHHELSSMEECEIIFDMVRDMQENLHMERAVFNLMRHLSFMIRADRMSLFMYRQR----NGIAE- 108

  Fly   459 LVSKLFDVCPRSTVEE--MEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGY 521
            |.:::|:|...:|:||  :....|:.....|||.||||.:.:.||:||..:|..|:..:|:||.|
Zfish   109 LATRIFNVHKDATLEECLVPPDSEIVYPLDTGIVGHVATAKKTVNVPDVTKDSHFSDFVDNLTEY 173

  Fly   522 RTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLEIK 586
            .||.:|..||.:.. |::.|...:||:....|:..||:....||.|..:.||...|......|.:
Zfish   174 ETKNVLATPIMNGK-DMVAVMMAVNKIGAPHFTAQDEETLKKYLNFANLVLRVFHLSYLHNCETR 237

  Fly   587 RNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQI----------------LLVHEADK 635
            |.||||..|..:|||.:.||....:.|..:::.:.|.|..:                :|:.|...
Zfish   238 RGQVLLWSASKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKTKEFFDLWPVLMGEVPP 302

  Fly   636 GS-----------FSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYE 689
            .|           |.:|.|:..:  .:|:.....:|....:.:..|:..:||..|...|:.||.:
Zfish   303 YSGPKTPDGREVIFYKVIDYILH--GKEDIKVIPNPPADHWALVSGLPTYVAENGLICNIMNAAQ 365

  Fly   690 DDRFDASVD--ENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGM 752
            |:.|:...:  :.|.:..:::|.:.|.|...:|:||....|:.:...|.:.||..:|:...|.|.
Zfish   366 DEFFEFQKEPLDESGWMIKNVLSLPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGW 430

  Fly   753 GIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLR---------------------- 795
            .:.||..|:|......::.:..:::.||.....||...:...|
Zfish   431 SVLNTDTYDKMNKLENRKDIFQDMVMYHVKCRKDEIQNILNTREMYDKEPDECEEDELEDILNEV 495

  Fly   796 VPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYH 860
            :|.:....:.:|.|.|..|.:.|.:|..::|:.:|..|::|||..|.|.|::.||.|.||.:|||
Zfish   496 LPDSEESEIFEFHFCDFEFSELDLVKCGIKMYYELGVVDKFHIPRETLVRFVYSVSKGYRKITYH 560

  Fly   861 NWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYST 925
            ||||.|||.|.||.:|.|....:.:.::|.:|::...||||:|||||||.:|:|:.:|||:|:.:
Zfish   561 NWRHGFNVGQTMFTLLMTGDLKRYYTDLEAMAMVTAGLCHDIDHRGTNNLYQMKSGNPLAKLHGS 625

  Fly   926 STMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQP- 989
            |.:|.||.:....:|......|..||:...:..||.:::.||::||||:|||||..|.:.|.|.
Zfish   626 SILERHHLEFGKTLLRDEALNIYQNLNRRQHETVIHLMDIAIIATDLALYFKKRTMFQKIVDQSK 690

  Fly   990 --------TSYWVAEEPR-ALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELN 1045
                    |.|.:.|..| .::.||.||.||||||.|||||:.:||..|::||:||||:|:..|.
Zfish   691 TYDSWDSWTKYMMLETTRKEIVMAMMMTACDLSAIAKPWEIQSKVALSVAAEFWEQGDLERTVLE 755

  Fly  1046 ITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTK 1110
            ..||.:|:|.|.:|||.:|..|||.:|..:|:.|:....::.|::|.:.:||..|..|.::.:.|
Zfish   756 QQPIPMMDRNKAEELPKLQCGFIDFVCSFVYKEFSRFHVEITPMLERLLNNRKEWNALKEIHEAK 820

  Fly  1111 TSQDQEPEEEQQQQNVISNGDCK 1133
            .::..|.::.:::.:  :|.|.|
Zfish   821 VAKLDEAKKAKEEAH--ANSDHK 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	51/163 (31%)
		GAF	611..762	CDD:214500	37/179 (21%)
		PDEase_I	859..1094	CDD:278654	104/244 (43%)
pde6a	NP_001007161.1	GAF	74..233	CDD:214500	51/164 (31%)
		GAF	255..442	CDD:214500	40/188 (21%)
		PDEase_I	559..803	CDD:278654	104/243 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750