Protein Alignment Pde11 and Pde1c

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Alignment Length: 1357
• Identity: 255/1357 - (18%)
• Similarity: 441/1357 - (32%)
• Gaps: 411/1357 - (30%)

  Fly    61 PATTGLHLRSIEEPATTPLQFQPTGRMNTEQ---GGTGYGGYGSSEHSLLIATRHAGVPLPL--- 119
            |....|:...:..|.|........||:|:.:   ||.  |..|.|....|:.|......|.|
  Fly    87 PRRESLNSCEVGSPGTMSSSLGKAGRLNSSRYPSGGA--GAIGLSVMGNLVGTTTRKCVLTLDGY 149

  Fly   120 ------AQHQPLPAHYQPLNHSGAAPPSSSNG-------SSSSGGGVQTSATPQQQQQYQVQQPY 171
                  :..:.||:.    ....:..|.||.|       |||||||.
  Fly   150 SYVIVASTPESLPSK----RDEASGGPGSSGGTSGAATSSSSSGGGA------------------ 192

  Fly   172 QYQYQHHYHHQANSPQHHRPYDPEHARMEAWLDENQEFVQDYFIRKATRQTVDAWLVSHATSAGN 236
                                                                       |:.|.:
  Fly   193 -----------------------------------------------------------ASGAAS 198

  Fly   237 DVVSSTSPTHANGQTSSSRGGSGATTPVRKISAHEFERGGLLKPIVNTIDGTPTFLSIGPPMDNG 301
            ..|...|.| |.|..|:|.|..|.:||.::.::          |.|:.:.|:.:..:|     ||
  Fly   199 GSVGPASGT-ATGTGSASGGAGGVSTPAQEAAS----------PTVSELSGSGSNATI-----NG 247

  Fly   302 SVG--GSCSNLQNVGGVVAGQYQYNHQQHHHNHAHLHHS-----------------QHSHYQAGG 347
            .|.  ||.:.::....  ....|::.|....:......:                 :.|...:||
  Fly   248 QVARHGSLTIIRRTNS--RNFTQFDGQLASPSSTACSSTAPGIGFAQTPLSEPLAERLSFRASGG 310

  Fly   348 AVGSSSLG----STGGASGAGGAPSLG-----GSGGAGNGHQYPYYHCHQRPQRLSRNELKQLDE 403
            :.||:|.|    |..|.|.:|.|.|..     .|..|.|       :.....|..|.|    |.:
  Fly   311 SNGSASAGDSRSSNQGPSNSGPAASAAVKMQPSSPNATN-------YLADNIQISSAN----LSQ 364

  Fly   404 KELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKKCLVSKLFDVCP 468
            .|::      :..:....|..|.|  ||.:      |:.||     .|...:            |
  Fly   365 TEMV------VGRDSADYTAMHSI--NVGV------GNSFL-----RGDTDI------------P 398

  Fly   469 RSTVEEMEQQDEVRVA---WGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALL--- 527
            :.:....|....:...   |.|       ||..||:.|||         ::...| |.::||
  Fly   399 QESGHSFETPSNMSFTAGQWDT-------ESLPPVDTPDA---------LNKAAG-RIRSLLRRM 446

  Fly   528 ---CMPIKDSSGDVIGVAQVINKM---------NGEC---------FSEIDEKVFSSYLQFCGIG 571
               .:..:|...::...|:|:..:         ||.|         ....|::      |.....
  Fly   447 DHETVAYEDMQRNLHYAARVLEAVFIDESREGCNGNCKNLNCSRHSHGRDDQQ------QDNNNS 505

  Fly   572 LRNAQLYEKS--------------QLEIKRNQVLLDLARMIFE-----EQSTIEHMVFRILTHMQ 617
            .|:..|.|.|              |..|:.....:..|.....     ..:|....:.:....:|
  Fly   506 NRSCSLQEASPGGAGAGVTPGADNQDSIESRTKGVSQAPQTHSGPTGPPSNTSSETIAQPAPKLQ 570

  Fly   618 SLIQCQRVQILLVHEA---DKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTG 679
            ..::..|..::  .|:   |.|..........:.|:.:..||.::..|..........|...::|
  Fly   571 PALETVRESVM--EESPSKDPGDKGPPPPASTSTLTSQTTTSSSATAEPSAKAAESQAGSAGSSG 633

  Fly   680 ETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQI--IGVIQLINKFNELDFT------ 736
            ...|....:...|........|...:::.|... .:.|.::  ..|...:.::....||
  Fly   634 SCSNPAAVHRQRRLRTPTWARSMSTNKTRLADE-DDELSEVQPDAVPPEVREWLASTFTRQMATS 697

  Fly   737 --KNDEN-FVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPS 798
              |:||. ...:.|.....||....||.:             |.|...:|...:..||.:
  Fly   698 RRKSDEKPKFRSVAHAIRAGIFVDRMYRR-------------VSSSALTAFPPDVVRLLK----- 744

  Fly   799 AVHFRLHDFKFDDIHFED---DDTLK-ACLRMFLDLDFVERFHIDYEVLCRWLLSVKK---NYRN 856
                .|.|:.||.....:   ...:| ....:|.....:.:|.|...:|..:|..|::   .|||
  Fly   745 ----NLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRN 805

  Fly   857 VTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQ 921
             .|||..||.:|.|.:...|..|.......::|..|.::..|.||.:|.||.|:|.:.:.|..|.
  Fly   806 -PYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETAL 869

  Fly   922 LYS-TSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLES 985
            ||: .:.:|:||......:|......||::||.:::..:..::.:.:|.||:..:|::    :::
  Fly   870 LYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQ----MKA 930

  Fly   986 VSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQ-ELNITPI 1049
            :.|..:...|...:..:.::.:..||:|...|.|.:..|...|:..|||.|||:||: .|..:|:
  Fly   931 MRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPL 995

  Fly  1050 DIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQD 1114
            ...|.....|   .|:.|||.|..|   :...:||.||.::
  Fly   996 CDRNNTLVAE---SQICFIDFIVEP---SMGVMSDMLELIL------------------------ 1030

  Fly  1115 QEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDSPSEKAS-VNGSNVANNSSNTNKKIAVAS 1178
                                          |.:|..:.|:.|: |.....||  |.||..|.:.:
  Fly  1031 ------------------------------APIAPMNKSKPATLVEHETTAN--STTNSAIVIPN 1063

  Fly  1179 H---PTSTQPSDDDNDVDADADDVDEQAAEENGHDAEVDEASCRSNSTCSSSTAS---------S 1231
            .   |:..:|.|                   :..:|:...|.|.:..:.:.:|||         :
  Fly  1064 SGITPSMDKPRD-------------------HRTEAKTTAAECLARKSVTGTTASKFNIPKPWLT 1109

  Fly  1232 CLSTPPPTGEDDSTPVSPLKTLQAKLVAANLNALQRQTSNQAQTQKQRCKSCDHSRS 1288
            ||.......::.:     :|..:|:.:|..........:.:|:..|...::.|..:|
  Fly  1110 CLVENKRIWKEQA-----VKDAEARALATAAEEAAAAAAAEAEESKPETETADGEQS 1161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	36/202 (18%)
		GAF	611..762	CDD:214500	27/164 (16%)
		PDEase_I	859..1093	CDD:459723	66/235 (28%)
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	11/60 (18%)
		PDEase_I	807..1027	CDD:459723	64/229 (28%)