Protein Alignment Pde11 and dnc

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Alignment Length: 1218
• Identity: 242/1218 - (19%)
• Similarity: 393/1218 - (32%)
• Gaps: 410/1218 - (33%)

  Fly    25 QQQQQQQQQQQQQQHQQQQQQTPSHSPQIQHHSEIIPATTGLHLRSIEEPATTPLQ--FQPTGRM 87
            |||||||||.||...|.|....||       ...|:...|   |.|...|:|.|.|  .|..|:
  Fly   242 QQQQQQQQQLQQPLLQSQPHFVPS-------SGNILSQVT---LYSGSNPSTNPCQSAVQNQGQ- 295

  Fly    88 NTEQGGTGYGGYGSSEHSLLIATRHAGVPLP------------------LAQHQPLP-------- 126
            |:............:::....:.:....|||                  |.:|||||
  Fly   296 NSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEESDQANFKHQTSLKEHQPLPPPITIATG 360

  Fly   127 --AHYQPLNHSGAAPPSSSNGSSSSGGG------VQTSATPQQQQQYQVQQPYQYQYQHHYHHQA 183
              ...:.::||.|.  |||.|:...||.      ..||:||..:.:.:.::|::
  Fly   361 YCGSCESVHHSSAT--SSSAGTVPPGGQQTQEYIAGTSSTPSPRIKLKFRKPHK----------- 412

  Fly   184 NSPQHHRPYDPEHARMEAWLDENQEFVQDYFIRKATRQTVDAW---LVSHATSAGNDVVSST--- 242
                                                    ..|   :::...|||....::|
  Fly   413 ----------------------------------------SCWSRIVLAPIGSAGGSSSATTVIG 437

  Fly   243 SPTHANGQTSSSRGGSGATTPVR---KISAHEFERGGLLKPIVNTIDGTPTFLSIGPPMDNGSVG 304
            |.::....:||:.||:..||...   .::||.           .....:.:.|:...|.::..:
  Fly   438 SNSNETLASSSTTGGTATTTQNSSSVSVAAHH-----------RLTSSSASALATSHPSNSQLL- 490

  Fly   305 GSCSNLQNVGGVVAGQYQYNHQQHHHNHAHLHHSQHSHYQAGGAVGSSSLGSTGGASGAGGAPSL 369
             ..|.:|...|.: |..|..|.::..|..|...:.....:.|....|               |..
  Fly   491 -PTSKMQAEQGSI-GDLQKYHSRYLKNRRHTLANVRFDVENGQGARS---------------PLE 538

  Fly   370 GGSGGAGNGHQYPYYHCHQR---------------PQRLSRNELKQLDEKELIFELVKDICNELE 419
            |||..||...|    :..||               |:.:|||       ..:..|..|:
  Fly   539 GGSPSAGLVLQ----NLPQRRESFLYRSDSDFEMSPKSMSRN-------SSIASERFKE------ 586

  Fly   420 VRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKKC---LVSKLFDVCPRSTVEEMEQQDEV 481
                     |..|||::...|...:|.........|:..   |:| |.:| |.|.......|
  Fly   587 ---------QEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLS-LTNV-PASNKSRRPNQ--- 637

  Fly   482 RVAWGTGIAGHVAESGEPVNIPDAYQDERFN------------C--EIDSLTGYRTKALLCMPIK 532
                    :...:.||.|...|.:..:|.:.            |  :::::..:|:       :.
  Fly   638 --------SSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRS-------VS 687

  Fly   533 DSSGDVIGVAQVINKMNGECFSEIDE--KVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLA 595
            |.:.  :...:::||.... |||...  ...|.|:  |...|...|.::...|.::.|..|: .|
  Fly   688 DMAS--LKFKRMLNKELSH-FSESSRSGNQISEYI--CSTFLDKQQEFDLPSLRVEDNPELV-AA 746

  Fly   596 RMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFEANDLSEEEATSRTSP 660
            .....:||.                               |.::|........:|:.....|...
  Fly   747 NAAAGQQSA-------------------------------GQYARSRSPRGPPMSQISGVKRPLS 780

  Fly   661 YESRFPINIGITGHVATTGET-----VNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQI 720
            :.:.|            |||.     |..|.                           :|.||.:
  Fly   781 HTNSF------------TGERLPTFGVETPR---------------------------ENELGTL 806

  Fly   721 IGVIQL--INKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASA 783
            :|.:..  |..|:..:|:.|......|:.||                    ||..|
  Fly   807 LGELDTWGIQIFSIGEFSVNRPLTCVAYTIF--------------------QSREL--------- 842

  Fly   784 TMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLL 848
                   |..|.:|....                            |:|:......|
  Fly   843 -------LTSLMIPPKTF----------------------------LNFMSTLEDHY-------- 864

  Fly   849 SVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQI 913
             ||.|    .:||..||.:|.|....:|.|.....:|..:|....:.....||:||.|..|.|.:
  Fly   865 -VKDN----PFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLV 924

  Fly   914 KASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFK 977
            .:||.||.:|: .|.:|:||......:|.:.|..|..|:.......:.:::.|.:||||::.:..
  Fly   925 NSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMS 989

  Fly   978 KRGPFLESVSQPTSYWVAEEPRALLRAMSMTV---------CDLSAITKPWEIEKRVADLVSSEF 1033
            ........|....   ||.....||...:..:         .|||..|||..:.||...|:..||
  Fly   990 LLADLKTMVETKK---VAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEF 1051

  Fly  1034 FEQGDMEKQE-LNITPI-DIMNREKEDELPMMQVNFIDSICLPIYEAFATL-SDKLEPLVEGVRD 1095
            |.|||.|::. ::|:|: |..|...|..    ||.|||.|..|::|.:|.| ....:.:::.:.:
  Fly  1052 FLQGDKERESGMDISPMCDRHNATIEKS----QVGFIDYIVHPLWETWADLVHPDAQDILDTLEE 1112

  Fly  1096 NRGHWIDLADVVKTKTSQDQEPE----------EEQQQQNV--ISNGD 1131
            ||.::..:.......:..|:.|:          ||..|:|:  :..||
  Fly  1113 NRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGD 1160

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	32/180 (18%)
		GAF	611..762	CDD:214500	21/157 (13%)
		PDEase_I	859..1094	CDD:278654	71/247 (29%)
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	71/247 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45459132
Domainoid	1	1.000	82	1.000	Domainoid score	I1950
eggNOG	1	0.900	-	-		E1_KOG3689
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46491
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850