DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and Pde8b

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_008758892.1	Gene:	Pde8b / 309962	RGDID:	735041	Length:	885	Species:	Rattus norvegicus

Alignment Length:	1040	Identity:	188/1040 - (18%)
Similarity:	337/1040 - (32%)	Gaps:	336/1040 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 HATSAG----NDVVSSTSPTHANGQTSSSRGGSGATTPVRKISAHEFERGGLLKPIVNTIDGTPT 290
            |.:.:|    .|...|.||.    ||||.  ..|.|.|:..:...           .:..|..|.
  Rat     8 HVSQSGVIYCRDSDESNSPR----QTSSV--SQGPTAPLHGLFVQ-----------TDAADAMPP 55

  Fly   291 FLSIGPPMDNGSVGGSCSNLQNVGGVVAGQYQYNHQQHHHNHAHLHHSQHSHYQAGGAVGSSSLG 355
            ..:.|||   |:|                                 ..:.|..:.|.       |
  Rat    56 SRAAGPP---GAV---------------------------------RVRRSRAELGS-------G 77

  Fly   356 STGGASGAGGAPSLGGSGGAGNGHQYPYYHCHQRPQRLSRNELKQLDEKELIFELVKDICNELEV 420
            |:.|:||.......|..           .||....:.          |.:..:..||.: :..||
  Rat    78 SSTGSSGPAATTCRGRR-----------RHCCSSAEA----------ETQTSYTSVKQV-SSAEV 120

  Fly   421 RTLCHKILQN-VSILL--------------NADRGSLFLVQGRCN---GPDGLKKCLVSKLFDVC 467
            |....::.|: :.:||              ..||...     |||   .|:...:|.:.|..::.
  Rat   121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGY-----RCNIARTPESALECFLDKHHEII 180

  Fly   468 PRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIK 532
                                              :.|..|...|:.|           .:|..|:
  Rat   181 ----------------------------------VIDHRQTRNFDAE-----------AVCRSIR 200

  Fly   533 DSS-GDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLAR 596
            .:: .:...:..|:::.:       |:...:|.|.....|. |.:..|.|.:....|:::
  Rat   201 ATNPSEHTVILAVVSQAS-------DDHEEASVLPLLHAGF-NRRFMENSSIIACYNELI----- 252

  Fly   597 MIFEEQSTIEH-------------MVFRILTHMQSLIQCQRVQ--ILLVHEADKGSFSRVFDFEA 646
                   .|||             .||..|.|....|:.....  |..|:.|    |.|:..:..
  Rat   253 -------QIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPA----FERMMGYHK 306

  Fly   647 NDLSEEEA---------------TSRT---------SPYESRFPINIGITGHV------------ 675
            .:|..:|.               |..|         ..|.:|......|..||
  Rat   307 GELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKI 371

  Fly   676 ----------ATTGETVNVPNAYEDDRFDASVDENSCFKHRS----------------------- 707
                      .||..:..:...:.|.. |.|..|...|:|:|
  Rat   372 RHFVSLKKLCCTTDSSKQIHRIHRDSG-DNSQTEPHSFRHKSRRKESIDVKSISSRGSDAPSLQN 435

  Fly   708 --------ILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAI 764
                    |..|.|:..:.::|.:|....:.:.:...:..:..:|.        :..|.:|...:
  Rat   436 RRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEI--------LRTTELYSPQL 492

  Fly   765 VAMAKQSVTLEVL--------------SYHASATMDEAHRLRRLRV------PSAVHFRLHDFKF 809
            ....:...|.:::              .|..:..:..:|....:.:      ||......::..:
  Rat   493 GTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHHSHSHLSMPITINDVPPSIAQLLDNEESW 557

  Fly   810 DDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLC------RWLLSVKKNYRNV-TYHNWRHAFN 867
            |...||.:........::|.|....||.:...:.|      .||..::.||.:. .|||..||.:
  Rat   558 DFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCTETTLRAWLQVIEANYHSSNAYHNSTHAAD 622

  Fly   868 VAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHH 931
            |.......|...:......:::.:|.:|....||:||.|..|||...|.|.||.||: |:.:|.|
  Rat   623 VLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESH 687

  Fly   932 H----FDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSY 992
            |    |.  |.:.::..| |..|:..:.|..:.:.:.|.:|:|::..:|:....|:.|:::|.:
  Rat   688 HTALAFQ--LTVKDTKCN-IFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPLA- 748

  Fly   993 WVAE----------------EPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEK 1041
              ||                |.:.|::.|.:...|::...:|.::....|..:|.|:|.|.|.||
  Rat   749 --AESEGSDCECNPTGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEK 811

  Fly  1042 QELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADV 1106
            ::.....:.:.:| ....:|..|::|||.....:::|:...: .|..|::.:.||..||..|.|:
  Rat   812 RQGLPVVMPVFDR-NTCSIPKSQISFIDYFITDMFDAWDAFA-HLPALMQHLADNYKHWKTLDDL 874

Fly 1107 1106
Rat 875 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	26/180 (14%)
		GAF	611..762	CDD:214500	34/229 (15%)
		PDEase_I	859..1094	CDD:278654	64/255 (25%)
Pde8b	XP_008758892.1	PDE8	1..47	CDD:285793	13/55 (24%)
		PAS_9	279..377	CDD:290162	15/101 (15%)
		PAS	284..376	CDD:238075	14/95 (15%)
		PDEase_I	614..861	CDD:278654	64/254 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347773
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850