DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde11 and Pde8a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_942062.1	Gene:	Pde8a / 308776	RGDID:	735125	Length:	823	Species:	Rattus norvegicus

Alignment Length:	795	Identity:	157/795 - (19%)
Similarity:	295/795 - (37%)	Gaps:	194/795 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 HQRPQRLSRNEL------KQLDEKELIFELVKDICNELEVRTL-------CHKILQNVSILLNAD 438
            |:.|:::....:      .:|.|..:|..:|:.:..| ||..:       ..:.::|.:::...:
  Rat   126 HRNPRQMDAEAMCRSIRSSKLSENTVIVGVVRRVDKE-EVSLMPFLAAGFTRRYIENPNVMACYN 189

  Fly   439 RGSLFLVQGRCNGPDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIP 503
            . .|.|..|.......|:.|  :.:|....:|. |.:|...|          .|:.:...|.
  Rat   190 E-LLQLAFGEVRSQLKLRAC--NSVFTALEKSQ-EAIEITSE----------DHIIQYANPA--- 237

  Fly   504 DAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIG--VAQV-INKMNGECFSEIDEKV-FSSY 564
                       .::..||:            ||::||  :||| ||:..|:....|:..| ....
  Rat   238 -----------FETTMGYQ------------SGELIGKELAQVPINEKKGDLLDAINSCVTIDKE 279

  Fly   565 LQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMV--FRIL---THMQSLIQCQR 624
            .|    |:.:.|  :|:...|::|..::.    :..:...|.|.|  .|:.   ..:::..:|.:
  Rat   280 WQ----GVYHTQ--KKNGDNIQQNVKIIP----VIGQGGKIRHYVSIIRVCNGSNKVETTTECVQ 334

  Fly   625 VQILLVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESR-----------FPINIGITGHVATT 678
            .......:|.|..     |...:.:..:..:||||...::           ..|...||
  Rat   335 TDSQTDSQAGKHK-----DRRKHSMDVKAVSSRTSEVSNQRRHSSLARIHSMMIEAPIT------ 388

  Fly   679 GETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFV 743
             :.:|:.:|         ..|||        .:::..:|..::.:::....::....|::|.:..
  Rat   389 -KVINILSA---------AQENS--------PVSVTEALNHVLDILRTTELYSPQFNTEDDPHAT 435

  Fly   744 EAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDF- 807
            :........|:..          .:....||...|...|::        :|.||    ..|||.
  Rat   436 DLVGGLMSDGLRR----------FSGNEYTLATKSLRPSSS--------QLAVP----ISLHDIP 478

  Fly   808 -----------KFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLC------RWLLSVKKNYR 855
                       ::|...||.:...:....::|.|....||.|...:.|      .|...::.||.
  Rat   479 PRIAQVIENEEQWDFDIFELEAATQNRPLIYLGLKTFARFEICEFLQCSEATLKSWFQIIESNYH 543

  Fly   856 NVT-YHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPL 919
            :.. |||..||.:|.......|:..:.......::.:|.:|....||:||.|..|||...|...|
  Rat   544 SSNPYHNSTHAADVLHATAYFLSRNKLKDTLDRLDEVAALIAATIHDVDHPGRTNSFLCNAGKEL 608

  Fly   920 AQLYS-TSTMEHHHF----------DQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLA 973
            |.||: |:.:|.||.          |:|         .|..|...:||..:.:.:.|.:|:|::.
  Rat   609 AVLYNDTAVLESHHAALAFQLTLENDKC---------NIFKNTDRNDYRTLRQSIIDMVLATEMT 664

  Fly   974 VYFKKRGPFLESVSQPTSYWVAE------------------EPRALLRAMSMTVCDLSAITKPWE 1020
            .:|:....|:.|:::|......|                  |.|.|::.|.:...|:|...:|.|
  Rat   665 KHFEHVNKFINSINKPLKAQKNEVQETGRSLEDIRAMVRTPESRTLIKRMMIKCADVSNPCRPLE 729

  Fly  1021 IEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDK 1085
            .....|..:|.|:|.|.|.||| |::..:..:.......:|..|::|||.....:::|:.... .
  Rat   730 HCIEWAARISEEYFSQTDEEKQ-LDLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFV-Y 792

  Fly  1086 LEPLVEGVRDNRGHW 1100
            |..|:..:.||..:|
  Rat   793 LPNLMRHLEDNFKYW 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	32/172 (19%)
		GAF	611..762	CDD:214500	21/164 (13%)
		PDEase_I	859..1094	CDD:278654	66/263 (25%)
Pde8a	NP_942062.1	PDE8	1..44	CDD:285793
		PAS_9	220..318	CDD:290162	28/143 (20%)
		PAS	224..318	CDD:238075	26/139 (19%)
		PDEase_I	548..801	CDD:278654	66/263 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347760
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940