Protein Alignment Pde11 and Pde8a

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_063118773.1
• Gene: Pde8a / 308776
• RGDID: 735125
• Length: 858
• Species: Rattus norvegicus
• Alignment Length: 731
• Identity: 141/731 - (19%)
• Similarity: 265/731 - (36%)
• Gaps: 192/731 - (26%)

  Fly   387 HQRPQRLSRNEL------KQLDEKELIFELVKDICNELEVRTL-------CHKILQNVSILLNAD 438
            |:.|:::....:      .:|.|..:|..:|:.:..| ||..:       ..:.::|.:::...:
  Rat   126 HRNPRQMDAEAMCRSIRSSKLSENTVIVGVVRRVDKE-EVSLMPFLAAGFTRRYIENPNVMACYN 189

  Fly   439 RGSLFLVQGRCNGPDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIP 503
            . .|.|..|.......|:.|  :.:|....:|. |.:|...|          .|:.:...|.
  Rat   190 E-LLQLAFGEVRSQLKLRAC--NSVFTALEKSQ-EAIEITSE----------DHIIQYANPA--- 237

  Fly   504 DAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIG--VAQV-INKMNGECFSEIDEKV-FSSY 564
                       .::..||:            ||::||  :||| ||:..|:....|:..| ....
  Rat   238 -----------FETTMGYQ------------SGELIGKELAQVPINEKKGDLLDAINSCVTIDKE 279

  Fly   565 LQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMV--FRIL---THMQSLIQCQR 624
            .|    |:.:.|  :|:...|::|..::.    :..:...|.|.|  .|:.   ..:::..:|.:
  Rat   280 WQ----GVYHTQ--KKNGDNIQQNVKIIP----VIGQGGKIRHYVSIIRVCNGSNKVETTTECVQ 334

  Fly   625 VQILLVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESR-----------FPINIGITGHVATT 678
            .......:|.|..     |...:.:..:..:||||...::           ..|...||
  Rat   335 TDSQTDSQAGKHK-----DRRKHSMDVKAVSSRTSEVSNQRRHSSLARIHSMMIEAPIT------ 388

  Fly   679 GETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFV 743
             :.:|:.:|         ..|||        .:::..:|..::.:::....::....|::|.:..
  Rat   389 -KVINILSA---------AQENS--------PVSVTEALNHVLDILRTTELYSPQFNTEDDPHAT 435

  Fly   744 EAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDF- 807
            :........|:..          .:....||...|...|::        :|.||    ..|||.
  Rat   436 DLVGGLMSDGLRR----------FSGNEYTLATKSLRPSSS--------QLAVP----ISLHDIP 478

  Fly   808 -----------KFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLC------RWLLSVKKNYR 855
                       ::|...||.:...:....::|.|....||.|...:.|      .|...::.||.
  Rat   479 PRIAQVIENEEQWDFDIFELEAATQNRPLIYLGLKTFARFEICEFLQCSEATLKSWFQIIESNYH 543

  Fly   856 NVT-YHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPL 919
            :.. |||..||.:|.......|:..:.......::.:|.:|....||:||.|..|||...|...|
  Rat   544 SSNPYHNSTHAADVLHATAYFLSRNKLKDTLDRLDEVAALIAATIHDVDHPGRTNSFLCNAGKEL 608

  Fly   920 AQLYS-TSTMEHHHF----------DQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLA 973
            |.||: |:.:|.||.          |:|         .|..|...:||..:.:.:.|.:|:|::.
  Rat   609 AVLYNDTAVLESHHAALAFQLTLENDKC---------NIFKNTDRNDYRTLRQSIIDMVLATEMT 664

  Fly   974 VYFKKRGPFLESVSQPTSYWVAE------------------EPRALLRAMSMTVCDLSAITKPWE 1020
            .:|:....|:.|:::|......|                  |.|.|::.|.:...|:|...:|.|
  Rat   665 KHFEHVNKFINSINKPLKAQKNEVQETGRSLEDIRAMVRTPESRTLIKRMMIKCADVSNPCRPLE 729

  Fly  1021 IEKRVADLVSSEFFEQ 1036
            .....|..:|.|:|.|
  Rat   730 HCIEWAARISEEYFSQ 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	32/172 (19%)
		GAF	611..762	CDD:214500	21/164 (13%)
		PDEase_I	859..1093	CDD:459723	53/207 (26%)
Pde8a	XP_063118773.1	None