Protein Alignment Pde11 and Pde3b

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_058925.2
• Gene: Pde3b / 29516
• RGDID: 61943
• Length: 1111
• Species: Rattus norvegicus
• Alignment Length: 628
• Identity: 121/628 - (19%)
• Similarity: 217/628 - (34%)
• Gaps: 183/628 - (29%)

  Fly   711 MAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGI--------------HNTHMYE 761
            :.:..|||.:         .:..||.:...|...:....||..|              ||....|
  Rat   534 VTLHRSLGSV---------SSAADFHQYLRNSDSSLCSSCGHQILKYVSTCEPDGTDHHNEKSGE 589

  Fly   762 KAIVAMAKQSVTLEVLSYHASATMDE----------AHRLRRLRVPSAVHFRLHDFKFDDIHFED 816
            :.....:|:  .|.::......|:.|          .|.:...:.|:..    .:...|.:..||
  Rat   590 EDSTVFSKE--RLNIVETQEEETVKEDCRELFLEGDDHLMEEAQQPNID----QEVLLDPMLVED 648

  Fly   817 DDTL---------------------------KACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNY 854
            .|:|                           :....:|.|...:|.|.|..:....:..:::..|
  Rat   649 YDSLIEKMSNWNFQIFELVEKMGEKSGRILSQVMYTLFQDTGLLETFKIPTQEFMNYFRALENGY 713

  Fly   855 RNVTYHNWRHAFNVAQMMFAILT-------------TTQWW------------------------ 882
            |::.|||..||.:|...::.:.|             .|:..
  Rat   714 RDIPYHNRVHATDVLHAVWYLTTRPIPGLQQLHNNHETETKADSDARLSSGQIAYLSSKSCCIPD 778

  Fly   883 KIFG-------EIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCL-M 938
            |.:|       .:|.:||.:....||.||.|..|:|.:..::|.|.||: .|.:|:||..... :
  Rat   779 KSYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNL 843

  Fly   939 ILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTS---YWVAEEPRA 1000
            .|:.|....|.||...::.|...::.:|||:|||..:|:....|....:...|   .|.:|..|.
  Rat   844 YLSRPEYNFLLNLDHMEFKRFRFLVIEAILATDLKKHFEFLAEFNAKANDVNSNGIEWSSENDRL 908

  Fly  1001 LLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQV 1065
            |:..:.:.:.|::...|..::..|..:.:.:||:|||| |:..|.: ||.........:|..:|.
  Rat   909 LVCQVCIKLADINGPAKDRDLHLRWTEGIVNEFYEQGD-EEATLGL-PISPFMDRSSPQLAKLQE 971

  Fly  1066 NFIDSICLPI---YEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVI 1127
            :||..|..|:   |:|...|.              |.||:..:...|::..|.:.:::....:
  Rat   972 SFITHIVGPLCNSYDAAGLLP--------------GQWIEAEEGDDTESDDDDDDDDDDDDDD-- 1020

  Fly  1128 SNGDCKAMSDDDVAASE------------------------------AEVAVDSPSEKASVNGSN 1162
             :.|.:.:..||....:                              .|:..:....||..|...
  Rat  1021 -DDDDEELDSDDEETEDNLNPKPQRRKGRRRIFCQLMHHLTENHKIWKEIIEEEEKCKAEGNKLQ 1084

  Fly  1163 VANNSSNTNKKIAVASHPTSTQPSDDDNDVDADADDVDEQAAE 1205
            |.|                ::.|..|:..|..:||:.:||..|
  Rat  1085 VDN----------------ASLPQADEIQVIEEADEEEEQMFE 1111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	11/64 (17%)
		PDEase_I	859..1094	CDD:278654	69/286 (24%)
Pde3b	NP_058925.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32
		Interaction with RAPGEF3. /evidence=ECO:0000250	1..32
		DUF3488	145..>264	CDD:403269
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	405..448
		Interaction with PIK3R6. /evidence=ECO:0000250	421..445
		PDEase_I	718..992	CDD:395177	68/275 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347768
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850