DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde11 and Pde4c

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001263694.1	Gene:	Pde4c / 290646	RGDID:	727918	Length:	671	Species:	Rattus norvegicus

Alignment Length:	318	Identity:	93/318 - (29%)
Similarity:	157/318 - (49%)	Gaps:	31/318 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   831 DFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALI 894
            |.::.|.|..:.|.|:||:::.:|. ||.|||..||.:|.|....:|.|.....:|.::|.||.|
  Rat   359 DLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAI 423

  Fly   895 IGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQILANLSSDDYCR 958
            ..|..||:||.|.:|.|.|..:|.||.:|: :|.:|:||......:|......|..|||:.....
  Rat   424 FACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLS 488

  Fly   959 VIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWV------AEEPRALLRAMSMTVC-DLSA 1014
            :.|::.|.:|:||::.:.......  :....:.||..|      ::..:.|   .|:..| |||.
  Rat   489 LRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVL---QSLVHCADLSN 550

  Fly  1015 ITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDELPMMQVNFIDSICLPIYEA 1078
            ..||..:.::..:.:.:|||:|||.|::. |:|:|   |..:....:...||.|||.|..|::|.
  Rat   551 PAKPLPLYRQWTERIMAEFFQQGDRERESGLDISP---MCDKHTASVEKSQVGFIDYIAHPLWET 612

  Fly  1079 FATL-SDKLEPLVEGVRDNRGHWIDL-----------ADVVKTKTSQDQEPEEEQQQQ 1124
            :|.| ....:.|::.:.||| .|...           .|..|.:.:.::..|||::.:
  Rat   613 WADLVHPDAQELLDTLEDNR-EWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDE 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500
		PDEase_I	859..1094	CDD:278654	74/246 (30%)
Pde4c	NP_001263694.1	PDEase_I	388..629	CDD:278654	74/246 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750