DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and Pde6b

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001099494.1	Gene:	Pde6b / 289878	RGDID:	1311039	Length:	856	Species:	Rattus norvegicus

Alignment Length:	867	Identity:	277/867 - (31%)
Similarity:	450/867 - (51%)	Gaps:	114/867 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 GN---GHQYPYYHCHQRPQRL-------------SRNELKQLDEKELIFELVKDICNELEVRTLC 424
            ||   .||  |:.....|:.:             |..||.|::|...:||||:|:...:.:..:.
  Rat    14 GNPTFAHQ--YFEKKLSPENVAGACEGGCLVDCGSLRELCQVEESAALFELVQDMQESVNMERVV 76

  Fly   425 HKILQNVSILLNADRGSLFLVQGRCNGPDGLKKCLVSKLFDVCPRSTVEE--MEQQDEVRVAWGT 487
            .|:|:.:..:|:|||.|||:.:.|    :|:.: |.::||.|.|.|.:|:  :....|:......
  Rat    77 FKVLRRLCTILHADRCSLFMYRQR----NGVAE-LATRLFSVQPDSLLEDCLVPPDSEIVFPLDI 136

  Fly   488 GIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGEC 552
            ||.||||::.:.:|:.|..:...|:...|.||.|.||.:|..||.:.. ||:.|...:||::|.|
  Rat   137 GIVGHVAQTKKMINVQDVAECPHFSPFADELTDYVTKNILSTPIMNGK-DVVAVIMAVNKLDGPC 200

  Fly   553 FSEIDEKVFSSYLQFCGIGLRNAQLYEKSQL---EIKRNQVLLDLARMIFEEQSTIEHMVFRILT 614
            |:..||.||:.||.|..:   |.::|..|.|   |.:|.||||..|..:|||.:.||....:...
  Rat   201 FTSEDEDVFTKYLNFATL---NLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFY 262

  Fly   615 HMQSLIQCQRVQI----------------LLVHEADKGS-----------FSRVFDFEANDLSEE 652
            .:::.:.|.|..:                :|:.||...|           |.:|.|:..:  .:|
  Rat   263 TVRAYLNCDRYSVGLLDMTKEKEFFDVWPVLMGEAQPYSGPRTPDGREIVFYKVIDYILH--GKE 325

  Fly   653 EATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRF---DASVDENSCFKHRSILCMAIK 714
            :.....:|....:.:..|:..:||.:|...|:.||..|:.|   :..:|| |.:..:::|.|.|.
  Rat   326 DIKVIPTPPADHWALTSGLPTYVAESGFICNIMNASADEMFNFQEGPLDE-SGWVIKNVLSMPIV 389

  Fly   715 NSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSY 779
            |...:|:||....|:.:...|...||..:|:...|.|..:.||..|:|......::.:..:::.|
  Rat   390 NKKEEIVGVATFYNRKDGKPFDDQDEVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLY 454

  Fly   780 H----------------------ASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKA 822
            |                      |....||..::.:..:|....|.:::|.|.|:...:.:.:|.
  Rat   455 HVRCDKDEIQEILPTRDRLGKEPADCEEDELGKILKEELPGPTKFDIYEFHFSDLECTELELVKC 519

  Fly   823 CLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGE 887
            .::|:.:|..|.:|.|..|||.|:|.||.|.||.:|||||||.|||||.||.:|.|.:....:.:
  Rat   520 GIQMYYELGVVRKFQIPQEVLVRFLFSVSKAYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTD 584

  Fly   888 IECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLS 952
            :|..|::...||||:|||||||.:|:|:.:|||:|:.:|.:|.||.:....:|......|..||:
  Rat   585 LEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLAEESLNIYQNLN 649

  Fly   953 SDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSY-----WV----AEEPR-ALLRAMSM 1007
            ...:..||.:::.||::||||:|||||..|.:.|.:..:|     ||    .|..| .::.||.|
  Rat   650 RRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDKKSWVEYLSLETTRKEIVMAMMM 714

  Fly  1008 TVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSIC 1072
            |.|||||||||||::.:||.||::||:||||:|:..|:..||.:|:|.|..|||.:||.|||.:|
  Rat   715 TACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVC 779

  Fly  1073 LPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCKAMSD 1137
            ..:|:.|:...:::.|:.:.:::||..|..|||..:.|.   :..|||::::            :
  Rat   780 TFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKV---KALEEEKKKE------------E 829

  Fly  1138 DDVAASEA--EVAVDSPSEKAS 1157
            |.|||.:|  |:....|:.|:|
  Rat   830 DRVAAKKAGTEICNGGPAPKSS 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	54/163 (33%)
		GAF	611..762	CDD:214500	40/180 (22%)
		PDEase_I	859..1094	CDD:278654	106/244 (43%)
Pde6b	NP_001099494.1	GAF	71..230	CDD:214500	56/167 (34%)
		GAF	252..439	CDD:214500	43/189 (23%)
		PDEase_I	556..801	CDD:278654	106/244 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347765
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750