DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and Pde4d

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001106799.1	Gene:	Pde4d / 24627	RGDID:	3281	Length:	803	Species:	Rattus norvegicus

Alignment Length:	985	Identity:	202/985 - (20%)
Similarity:	356/985 - (36%)	Gaps:	272/985 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 PMDNGSVGGSCSNLQNVGGVV--AGQYQYNHQQHH------------HNHAHLHHSQHSHYQAGG 347
            |...||..||.|:    ||..  |.::.:.|:|||            |.|.||........|
  Rat     9 PARAGSDEGSDSS----GGAALKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQ--- 66

  Fly   348 AVGSSSL---------------GSTGGASGAGGAPSLGGSGGAGNGHQYPYYHCHQRPQRLSRNE 397
                ..|               |:|.|...:.||..:...|.:....   |.:|..
  Rat    67 ----PQLQPPPPPPLPPPPPPPGATRGRYASSGASRVRHRGYSDTER---YLYCRA--------- 115

  Fly   398 LKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKKCLVS- 461
                                                   .||.|..:..|.   ..||||..:|
  Rat   116 ---------------------------------------MDRTSYAVETGH---RPGLKKSRMSW 138

  Fly   462 -------KLFDV-----CPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCE 514
                   :.|||     ..||.::.|...       |:|:   :.::    |...:.:.|.|...
  Rat   139 PSSFQGLRRFDVDNGTSAGRSPLDPMTSP-------GSGL---ILQA----NFVHSQRRESFLYR 189

  Fly   515 IDSLTGYRTKALLCMPIKDSS------GD---VIGVAQVINKM-----NGECFSEIDEKVFSSYL 565
            .||......|::    .::||      ||   |...|||:..:     |....:.:.::..|...
  Rat   190 SDSDYDLSPKSM----SRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRS 250

  Fly   566 QFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQIL-L 629
            ..|            :|..|.:..:..:..:.:..|  |:|.:.:       .|.|.:.:|.. .
  Rat   251 PMC------------NQPSINKATITEEAYQKLASE--TLEELDW-------CLDQLETLQTRHS 294

  Fly   630 VHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFD 694
            |.|.....|.|:.:.|...|||   .||:....|.:     |:.........|.:|:..:.:
  Rat   295 VSEMASNKFKRMLNRELTHLSE---MSRSGNQVSEY-----ISNTFLDKQHEVEIPSPTQKE--- 348

  Fly   695 ASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHM 759
                     |.:.      |..:.||.||.:|                           :|::.:
  Rat   349 ---------KEKK------KRPMSQISGVKKL---------------------------MHSSSL 371

  Fly   760 YEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACL 824
            ....|.....::...:||    :..:::.::           :.||.|:..::  ..:..|...:
  Rat   372 TNSCIPRFGVKTEQEDVL----AKELEDVNK-----------WGLHVFRIAEL--SGNRPLTVIM 419

  Fly   825 R-MFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGE 887
            . :|.:.|.::.|.|..:.|..:|::::.:|. :|.|||..||.:|.|....:|:|.....:|.:
  Rat   420 HTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTD 484

  Fly   888 IECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQILANL 951
            :|.||.|.....||:||.|.:|.|.|..:|.||.:|: :|.:|:||......:|......|..||
  Rat   485 LEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNL 549

  Fly   952 SSDDYCRVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWV------AEEPRALLRAMSMT 1008
            :......:.::..|.:|:||::.:.......  :....:.||..|      ::..:.|   .:|.
  Rat   550 TKKQRQSLRKMAIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL---QNMV 611

  Fly  1009 VC-DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPI-DIMNREKEDELPMMQVNFIDS 1070
            .| |||..|||.::.::..|.:..|||.|||.|::. :.|:|: |..|...|..    ||.|||.
  Rat   612 HCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKS----QVGFIDY 672

  Fly  1071 ICLPIYEAFATL-SDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCKA 1134
            |..|::|.:|.| ....:.:::.:.||| .|      .::...|...|..:.|:..        .
  Rat   673 IVHPLWETWADLVHPDAQDILDTLEDNR-EW------YQSTIPQSPSPAPDDQEDG--------R 722

  Fly  1135 MSDDDVAASEAEVAVDSPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQ-PSDDDNDVDADADD 1198
            ....:....|..:..|..|:....:||.|..::|.::.|........||: |.|:..:.:|.|
  Rat   723 QGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVA-- 785

  Fly  1199 VDEQAAEENG 1208
             :|::..:.|
  Rat   786 -EEESQPQTG 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	34/188 (18%)
		GAF	611..762	CDD:214500	25/151 (17%)
		PDEase_I	859..1094	CDD:278654	73/247 (30%)
Pde4d	NP_001106799.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103		24/104 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..358		4/37 (11%)
		PDEase_I	456..697	CDD:278654	73/247 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	705..724		3/26 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..803		16/66 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347772
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850