Protein Alignment Pde11 and Pde4d

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001106799.1
• Gene: Pde4d / 24627
• RGDID: 3281
• Length: 803
• Species: Rattus norvegicus
• Alignment Length: 985
• Identity: 202/985 - (20%)
• Similarity: 356/985 - (36%)
• Gaps: 272/985 - (27%)

  Fly   297 PMDNGSVGGSCSNLQNVGGVV--AGQYQYNHQQHH------------HNHAHLHHSQHSHYQAGG 347
            |...||..||.|:    ||..  |.::.:.|:|||            |.|.||........|
  Rat     9 PARAGSDEGSDSS----GGAALKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQ--- 66

  Fly   348 AVGSSSL---------------GSTGGASGAGGAPSLGGSGGAGNGHQYPYYHCHQRPQRLSRNE 397
                ..|               |:|.|...:.||..:...|.:....   |.:|..
  Rat    67 ----PQLQPPPPPPLPPPPPPPGATRGRYASSGASRVRHRGYSDTER---YLYCRA--------- 115

  Fly   398 LKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKKCLVS- 461
                                                   .||.|..:..|.   ..||||..:|
  Rat   116 ---------------------------------------MDRTSYAVETGH---RPGLKKSRMSW 138

  Fly   462 -------KLFDV-----CPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCE 514
                   :.|||     ..||.::.|...       |:|:   :.::    |...:.:.|.|...
  Rat   139 PSSFQGLRRFDVDNGTSAGRSPLDPMTSP-------GSGL---ILQA----NFVHSQRRESFLYR 189

  Fly   515 IDSLTGYRTKALLCMPIKDSS------GD---VIGVAQVINKM-----NGECFSEIDEKVFSSYL 565
            .||......|::    .::||      ||   |...|||:..:     |....:.:.::..|...
  Rat   190 SDSDYDLSPKSM----SRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRS 250

  Fly   566 QFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQIL-L 629
            ..|            :|..|.:..:..:..:.:..|  |:|.:.:       .|.|.:.:|.. .
  Rat   251 PMC------------NQPSINKATITEEAYQKLASE--TLEELDW-------CLDQLETLQTRHS 294

  Fly   630 VHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFD 694
            |.|.....|.|:.:.|...|||   .||:....|.:     |:.........|.:|:..:.:
  Rat   295 VSEMASNKFKRMLNRELTHLSE---MSRSGNQVSEY-----ISNTFLDKQHEVEIPSPTQKE--- 348

  Fly   695 ASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHM 759
                     |.:.      |..:.||.||.:|                           :|::.:
  Rat   349 ---------KEKK------KRPMSQISGVKKL---------------------------MHSSSL 371

  Fly   760 YEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACL 824
            ....|.....::...:||    :..:::.::           :.||.|:..::  ..:..|...:
  Rat   372 TNSCIPRFGVKTEQEDVL----AKELEDVNK-----------WGLHVFRIAEL--SGNRPLTVIM 419

  Fly   825 R-MFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGE 887
            . :|.:.|.::.|.|..:.|..:|::::.:|. :|.|||..||.:|.|....:|:|.....:|.:
  Rat   420 HTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTD 484

  Fly   888 IECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQILANL 951
            :|.||.|.....||:||.|.:|.|.|..:|.||.:|: :|.:|:||......:|......|..||
  Rat   485 LEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNL 549

  Fly   952 SSDDYCRVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWV------AEEPRALLRAMSMT 1008
            :......:.::..|.:|:||::.:.......  :....:.||..|      ::..:.|   .:|.
  Rat   550 TKKQRQSLRKMAIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL---QNMV 611

  Fly  1009 VC-DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPI-DIMNREKEDELPMMQVNFIDS 1070
            .| |||..|||.::.::..|.:..|||.|||.|::. :.|:|: |..|...|..    ||.|||.
  Rat   612 HCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKS----QVGFIDY 672

  Fly  1071 ICLPIYEAFATL-SDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCKA 1134
            |..|::|.:|.| ....:.:::.:.||| .|      .::...|...|..:.|:..        .
  Rat   673 IVHPLWETWADLVHPDAQDILDTLEDNR-EW------YQSTIPQSPSPAPDDQEDG--------R 722

  Fly  1135 MSDDDVAASEAEVAVDSPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQ-PSDDDNDVDADADD 1198
            ....:....|..:..|..|:....:||.|..::|.::.|........||: |.|:..:.:|.|
  Rat   723 QGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVA-- 785

  Fly  1199 VDEQAAEENG 1208
             :|::..:.|
  Rat   786 -EEESQPQTG 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	34/188 (18%)
		GAF	611..762	CDD:214500	25/151 (17%)
		PDEase_I	859..1093	CDD:459723	73/246 (30%)
Pde4d	NP_001106799.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103		24/104 (23%)
		PDE4_UCR	218..334	CDD:465648	27/144 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..358		4/37 (11%)
		PDEase_I	456..696	CDD:459723	73/246 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	705..724		3/26 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..803		16/66 (24%)