DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and Pde4b

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_038965199.1	Gene:	Pde4b / 24626	RGDID:	3280	Length:	736	Species:	Rattus norvegicus

Alignment Length:	817	Identity:	177/817 - (21%)
Similarity:	298/817 - (36%)	Gaps:	208/817 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   453 DGLK---KCLVSKLFDV--------------CPRSTVE----EMEQQDEVRVAWGTGIAGHVAES 496
            |.||   :|.:||.:..              |....::    ...|.:..|...|.||:
  Rat    14 DNLKDYFECSLSKSYSSSSYTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGIS------ 72

  Fly   497 GEPVNIP---------DAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGEC 552
             .|..:|         .....|.|:.|.....|   ::.|......|||.|:..|...:....|.
  Rat    73 -RPTTLPLTTLPSIAITTVSQECFDVENGPSPG---RSPLDPQASSSSGLVLHAAFPGHSQRRES 133

  Fly   553 F-------SEIDEKVFSSYLQFCGIGLRNAQLYEK----------------SQLEIKRNQVLL-- 592
            |       .::..|..|          ||:.|..:                |...::.|..||
  Rat   134 FLYRSDSDYDLSPKAMS----------RNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTLLTN 188

  Fly   593 ---------------DLARMIFEEQSTIEHMVFRILTHMQ-SLIQCQRVQIL-LVHEADKGSFSR 640
                           .:.|:..:|:| .:.:....|..:. .|.|.:.:|.. .|.|.....|.|
  Rat   189 LHGAPNKRSPAASQAPVTRVSLQEES-YQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKR 252

  Fly   641 VFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDENSCFKH 705
            :.:.|...|||   .||:....|.:     |:.........|.:|:..:.||      |..  |.
  Rat   253 MLNRELTHLSE---MSRSGNQVSEY-----ISNTFLDKQNDVEIPSPTQKDR------EKK--KK 301

  Fly   706 RSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQ 770
            :.::.        ||.||.:|::. :.|:.|.     :..|    |:...|.....|.:..:.|.
  Rat   302 QQLMT--------QISGVKKLMHS-SSLNNTS-----ISRF----GVNTENEDHLAKELEDLNKW 348

  Fly   771 SVTL-EVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACL--RMFLDLDF 832
            .:.: .|..|..:..:                                    .|:  .:|.:.|.
  Rat   349 GLNIFNVAGYSHNRPL------------------------------------TCIMYAIFQERDL 377

  Fly   833 VERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIG 896
            ::.|.|..:....::::::.:|. :|.|||..||.:|||....:|:|.....:|.::|.||.|..
  Rat   378 LKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFA 442

  Fly   897 CLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVI 960
            ...||:||.|.:|.|.|..:|.||.:|: .|.:|:||......:|......|..||:......:.
  Rat   443 AAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKKQRQTLR 507

  Fly   961 RVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWVA-----EEPRALLRAMSMTVC-DLSAITK 1017
            :::.|.:|:||::.:.......  :....:.||..|.     .:...:||  :|..| |||..||
  Rat   508 KMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLR--NMVHCADLSNPTK 570

  Fly  1018 PWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFAT 1081
            ..|:.::..|.:..|||:|||.|::. :.|:|   |..:....:...||.|||.|..|::|.:|.
  Rat   571 SLELYRQWTDRIMEEFFQQGDKERERGMEISP---MCDKHTASVEKSQVGFIDYIVHPLWETWAD 632

  Fly  1082 L--------SDKLE----------------PLVEGVRDNRGHWIDLADVVKTKTSQDQE-PEEEQ 1121
            |        .|.||                ||.|..||.:| .::......|...:|.| ||:|.
  Rat   633 LVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQG-LMEKFQFELTLEEEDSEGPEKEG 696

  Fly  1122 QQQNVISNGDCKAMSDDDVAASEAEVAVDSPSEKASV 1158
            :..|..|:.....:.|.:...|..|..:|..:|..|:
  Rat   697 EGPNYFSSTKTLCVIDPENRDSLEETDIDIATEDKSL 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	31/181 (17%)
		GAF	611..762	CDD:214500	32/152 (21%)
		PDEase_I	859..1094	CDD:278654	79/268 (29%)
Pde4b	XP_038965199.1	PDE4_UCR	166..281	CDD:407935	23/123 (19%)
Pde4b	XP_038965199.1	PDEase_I	405..646	CDD:395177	74/245 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920