Protein Alignment Pde11 and Pde5a

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_700471.2
• Gene: Pde5a / 242202
• MGIID: 2651499
• Length: 865
• Species: Mus musculus
• Alignment Length: 1000
• Identity: 424/1000 - (42%)
• Similarity: 559/1000 - (55%)
• Gaps: 200/1000 - (20%)

  Fly   184 NSPQHHRPYDPEHARMEAWLDENQEFVQDYFIRKATRQTVDAW--------------LVSHATSA 234
            ||.:..:..||:.  :|||||::::|...||||||||..|:||              :.:|..|.
Mouse     7 NSVRSQQQRDPDW--VEAWLDDHRDFTFSYFIRKATRDMVNAWFSERVHNIPVCKEGIRAHTESC 69

  Fly   235 GNDVVSSTSPTHANGQTSSSRGGSGATTPVRKISAHEFERGGLLKPI-VNTIDGTPTFLS----- 293
            ...:..|   .||:..|..:        |.|||||.||:|.  |:|| |...:||.:|||
Mouse    70 SCSLQQS---PHADNTTPGA--------PARKISASEFDRP--LRPIVVKDSEGTVSFLSDSGKK 121

  Fly   294 ----IGPPMDNGSVGGSCSNLQNVGGVVAGQYQYNHQQHHHNHAHLHHSQHSHYQAGGAVGSSSL 354
                :.||..:...|..||.|
Mouse   122 EQMPLTPPRFDSDEGDQCSRL-------------------------------------------- 142

  Fly   355 GSTGGASGAGGAPSLGGSGGAGNGHQYPYYHCHQRPQRLSRNELKQLDEKELIFELVKDICNELE 419
                                                                 .||||||.:.|:
Mouse   143 -----------------------------------------------------LELVKDISSHLD 154

  Fly   420 VRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLK-KCLVSKLFDVCPRSTVEEMEQQDEVRV 483
            |..|||||..::..|::|||.|||||   |.  |..| |.|:|:||||...||:|| ...:.:|:
Mouse   155 VTALCHKIFLHIHGLISADRYSLFLV---CE--DSSKDKFLISRLFDVAEGSTLEE-ASNNCIRL 213

  Fly   484 AWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKM 548
            .|..||.||||..|||:||.|||:|.|||.|:|.:|||:|:::||||||:...:|:||||.|||.
Mouse   214 EWNKGIVGHVAAFGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKK 278

  Fly   549 --NGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFR 611
              ||..|:|.|||.|::||.||||.|.||||||.|.||.||||||||||.:|||||.::|.::.:
Mouse   279 SGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKK 343

  Fly   612 ILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFEAND-------LSEEEATSRTSPYESRFPINI 669
            |...:.|.:|.|:..|.:|.|....||||||..|..:       |:.|:..::         ||.
Mouse   344 IAATIISFMQVQKCTIFIVDEDCPDSFSRVFHMECEEVGKPSDPLTREQDANK---------INY 399

  Fly   670 GITGHVATTGETVNVPNAYEDDRFDASVDEN------SCFKHRSILCMAIKN-SLGQIIGVIQLI 727
            ....:|..|.|.:|:|:..:|.||..: :||      .|.  .|:||..||| ...::|||.||:
Mouse   400 MYAQYVKNTMEPLNIPDVTKDKRFPWT-NENMGHVNTPCI--GSLLCTPIKNGKKNKVIGVCQLV 461

  Fly   728 NKFNE-----LDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDE 787
            ||..|     ..|.:|||.|:|||.||||:||.||.|||....|||||.||||||||||||..:|
Mouse   462 NKMEENTGKIKAFNQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEE 526

  Fly   788 AHRLRRLR---VPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLS 849
            ...|:.|.   ||||...::.||.|.|....|.:|....:|||.||:.|:.|.:.:||||||:||
Mouse   527 TRELQALSAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILS 591

  Fly   850 VKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQI 913
            |||||| ||.|||||||||.||.|||.|...:......::|.|||:|..|.|||||||.|||:..
Mouse   592 VKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLETLALLIAALSHDLDHRGVNNSYIQ 656

  Fly   914 KASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKK 978
            ::..||||||..|.|||||||||||||||||||||:.||.|:|...:::::.|||:||||:|.|:
Mouse   657 RSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIDEYKTTLKIIKQAILATDLALYIKR 721

  Fly   979 RGPFLESVSQPTSYWVAEEP--RALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEK 1041
            ||.|.|.:.:  :.:..|:|  :.|..||.||.||||||||||.|::|:|:||::|||:|||.|:
Mouse   722 RGEFFELIRK--NQFSFEDPLQKELFLAMLMTACDLSAITKPWPIQQRIAELVAAEFFDQGDRER 784

  Fly  1042 QELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADV 1106
            :|||:.|.|:|||||::::|.|||.|||:|||.:|||...:|:...||::|.|.||..|..||
Mouse   785 KELNMEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCLPLLDGCRKNRQKWQALA-- 847

  Fly  1107 VKTKTSQDQEPEEEQQQQNVISNGD 1131
                          :||:.::.||:
Mouse   848 --------------EQQEKMLLNGE 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	90/164 (55%)
		GAF	611..762	CDD:214500	61/169 (36%)
		PDEase_I	859..1093	CDD:459723	131/235 (56%)
Pde5a	NP_700471.2	GAF	154..311	CDD:214500	88/162 (54%)
		GAF	337..503	CDD:214500	63/177 (36%)
		PDEase_I	602..836	CDD:459723	131/235 (56%)