DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and Pde11a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_006499516.1	Gene:	Pde11a / 241489	MGIID:	3036251	Length:	1011	Species:	Mus musculus

Alignment Length:	921	Identity:	391/921 - (42%)
Similarity:	543/921 - (58%)	Gaps:	75/921 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 EHARMEAWLDENQEFVQDYFIRKATRQTVDAWLVSHATSAGNDVVSSTSPTHANGQT---SSSRG 256
            :...:|.:||.:.|..:||.:||..::.||.||..|.:..|   .||..|..|...:   |:::|
Mouse     7 DFGEVETFLDRHPELFEDYLMRKGKQELVDKWLQRHTSGQG---ASSLRPALAGASSLAQSNAKG 68

  Fly   257 G---SGATTPVRKISAHEFERGGLLKPIVNTIDGTPTFLSIGPPMDNGSVGGSCSNLQNVGGVVA 318
            .   .|...|.....:|....||       ...|.|    :.|...:||.|.  .:||.    .|
Mouse    69 SPGIGGGAGPQGSAHSHPTPGGG-------ESAGVP----LSPSWASGSRGD--GSLQR----RA 116

  Fly   319 GQYQYNHQQHHHNHAHLHHSQHSHYQAGGAVGSSSLGSTGGASGAGGAPSLGGSGGAGNGH---- 379
            .|.:...........|::.:......:......||:........|...|..       ..|
Mouse   117 SQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPT-------TAHILSA 174

  Fly   380 ---------QYP----YYHCHQRPQRLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNV 431
                     |||    .|.||          ||:.:|::...||||||.|:|::.:|.:|||..|
Mouse   175 LLESRVNLPQYPPTAIDYKCH----------LKKHNERQFFLELVKDISNDLDLTSLSYKILIFV 229

  Fly   432 SILLNADRGSLFLVQGRCNGPDGLKKCLVSKLFDV---CPRSTVEEMEQQDEVRVAWGTGIAGHV 493
            .::::|||.|||||:|...|    ||.||||.|||   .|.......|..:||:|.||.||.|:|
Mouse   230 CLMVDADRCSLFLVEGAAAG----KKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYV 290

  Fly   494 AESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKM-NGECFSEID 557
            .|.||.|||||||||.|||.|||.||||:||:||||||::|.|::|||||.|||: .|..|:|.|
Mouse   291 GEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRNSDGEIIGVAQAINKVPEGAPFTEDD 355

  Fly   558 EKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQC 622
            |||...||.||||.:.||||:..|:.|.:|::.||::...:||||:.:|.:|.:|:...|:|::|
Mouse   356 EKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC 420

  Fly   623 QRVQILLVHEADKG--SFSRVFDFEANDLSEEEATSRTSPYE----SRFPINIGITGHVATTGET 681
            :|..:||:.:.:..  .|::.|:..:...|.:...|.....|    |.:.||..|...||:||..
Mouse   421 ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESVEKSSYSDWLINNSIAELVASTGLP 485

  Fly   682 VNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAF 746
            |||.:||:|.||||..|:.|.|..||:||:.|.||..|||||.|::|:.:...|...|:...|||
Mouse   486 VNVSDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAF 550

  Fly   747 AIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDD 811
            .||||:||:||.||::...:.|||||.|:||||||:.:..|..:.:...:|......:.|..|||
Mouse   551 VIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDD 615

  Fly   812 IHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAIL 876
            ...:.|..:.|.||||::|..|::|.||||.||||||:|:||||.|.||||||||||.|:|||:|
Mouse   616 FSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 680

  Fly   877 TTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYSTS-TMEHHHFDQCLMIL 940
            ||..:.:|..|:|.||:|:||||||||||||||:||.|:.|.|||||.|| |:|||||:..:|||
Mouse   681 TTAGFQEILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSDSALAQLYGTSATLEHHHFNHAVMIL 745

  Fly   941 NSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEPRALLRAM 1005
            .|.|:.|.|||||.:|..::::|:.:||:|||.:||::|..|.|.|.:....|.....|.:.|:|
Mouse   746 QSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVRKGDYDWSITSHRDVFRSM 810

  Fly  1006 SMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDS 1070
            .||.|||.|:||||||.::||:||:||||||||.|:.||.:||..|.:|.::||||.:|:.:|||
Mouse   811 LMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERSELKLTPSAIFDRNRKDELPRLQLEWIDS 875

  Fly  1071 ICLPIYEAFAT 1081
            ||:|:|::..:
Mouse   876 ICMPLYQSIGS 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	92/165 (56%)
		GAF	611..762	CDD:214500	62/156 (40%)
		PDEase_I	859..1094	CDD:278654	125/224 (56%)
Pde11a	XP_006499516.1	GAF	217..380	CDD:214500	92/166 (55%)
		GAF	402..568	CDD:214500	64/165 (39%)
		PDEase_I	663..885	CDD:365964	125/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844392
Domainoid	1	1.000	280	1.000	Domainoid score	I1674
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	698	1.000	Inparanoid score	I672
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002593
OrthoInspector	1	1.000	-	-		oto92760
orthoMCL	1	0.900	-	-		OOG6_100960
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.690