Protein Alignment Pde11 and Pde10a

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_017172949.1
• Gene: Pde10a / 23984
• MGIID: 1345143
• Length: 891
• Species: Mus musculus
• Alignment Length: 733
• Identity: 248/733 - (33%)
• Similarity: 391/733 - (53%)
• Gaps: 62/733 - (8%)

  Fly   390 PQRLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVS----ILLNADRGSLFLVQGRCN 450
            |:.:||  .:..:.:.:::||...|...|:.....|.:|..:|    |...||..:|:.: |.||
Mouse   165 PKEVSR--YQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFL-GECN 226

  Fly   451 G------PDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDE 509
            .      |.|:|:. ..:|....|              :..||.|:.:||:|.:.:.:.|...||
Mouse   227 NSLCVFIPPGMKEG-QPRLIPAGP--------------ITQGTTISAYVAKSRKTLLVEDILGDE 276

  Fly   510 RFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRN 574
            ||.......:|.|.:::||:||..:.||:||:.::......|.|....::|.::.|.:..:.:..
Mouse   277 RFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQ 341

  Fly   575 AQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADKGSFS 639
            .|:......:.:.|..|||:::..|:....|:.::..|:.:.::|:...|..:..|...:|..:|
Mouse   342 VQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYS 406

  Fly   640 RVFDFEANDLSEEE----ATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDEN 700
            .:|     |:.||:    ...:|.  |.||.|..||.|.||.|||.:|:|:||.|.||:..||..
Mouse   407 DLF-----DIGEEKEGKPIFKKTK--EIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLY 464

  Fly   701 SCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIV 765
            :.:..|:||||.|. |.|.:|||:|::||.:...|:|.|||..:.||:||.:.:|..:||.:...
Mouse   465 TGYTTRNILCMPIV-SRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRH 528

  Fly   766 AMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDL 830
            :.....||:|.||||:..|.:|...|.|..:|:.:...:..|.||...||:         |:..:
Mouse   529 SECIYRVTMEKLSYHSICTSEEWQGLMRFNLPARICRDIELFHFDIGPFEN---------MWPGI 584

  Fly   831 DFVERFH-------IDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEI 888
             ||...|       .:.|.|||:::|||||||.|.||||:||..||..|:|||....  .:|.::
Mouse   585 -FVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNN--GLFTDL 646

  Fly   889 ECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSS 953
            |...|:|.||||||||||.:||:..|...|||.||||||||.|||.|.:.||...|:.|.:.|||
Mouse   647 ERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSS 711

  Fly   954 DDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEP-RALLRAMSMTVCDLSAITK 1017
            .:|.:|:.::..||::||||:||..|.. ||.:.|..|..:..:. |..:..:.||.|||.::||
Mouse   712 SEYEQVLEIIRKAIIATDLALYFGNRKQ-LEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTK 775

  Fly  1018 PWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATL 1082
            .|.:.|..|:.:.:||:.:|| |.::|.|.||.:|:|:|.||:|..|:.|.:::.:|.|.....:
Mouse   776 LWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQI 839

  Fly  1083 SDKLEPLVEGVRDNRGHW 1100
            ....|||::..|||...|
Mouse   840 LPPTEPLLKACRDNLNQW 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	41/171 (24%)
		GAF	611..762	CDD:214500	58/154 (38%)
		PDEase_I	859..1093	CDD:459723	99/234 (42%)
Pde10a	XP_017172949.1	GAF	<170..>354	CDD:441805	46/201 (23%)
		GAF	372..527	CDD:214500	59/162 (36%)
		PDEase_I	619..850	CDD:459723	99/234 (42%)