Protein Alignment Pde11 and Pde4d

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001389812.1
• Gene: Pde4d / 238871
• MGIID: 99555
• Length: 803
• Species: Mus musculus
• Alignment Length: 1041
• Identity: 211/1041 - (20%)
• Similarity: 366/1041 - (35%)
• Gaps: 320/1041 - (30%)

  Fly   259 GATTPVRKISAHEFERGGLLKPIVNTIDGTPTFLSIGPPMDNGSVGGSCSNLQNVGGVVAGQYQY 323
            |::.|.|.:|    |.|                        |.|.||:        .:.|.::.:
Mouse     5 GSSVPARAVS----EEG------------------------NDSAGGA--------ALKAPKHLW 33

  Fly   324 NHQQHH------------HNHAHLHHSQHSHYQAGGAVGSSSL---------------GSTGGAS 361
            .|:|||            |.|.||........|       ..|               |:|.|..
Mouse    34 RHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQ-------PQLQPPPPPPLPPPPPPPGATRGRY 91

  Fly   362 GAGGAPSLGGSGGAGNGHQYPYYHCHQRPQRLSRNELKQLDEKELIFELVKDICNELEVRTLCHK 426
            .:.||..:...|.:....   |.:|..
Mouse    92 ASSGASRVRHRGYSDTER---YLYCRA-------------------------------------- 115

  Fly   427 ILQNVSILLNADRGSLFLVQGRCNGPDGLKKCLVS--------KLFDV-----CPRSTVEEMEQQ 478
                      .||.|..:..|.   ..||||..:|        :.|||     ..||.::.|...
Mouse   116 ----------MDRTSYAVETGH---RPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSP 167

  Fly   479 DEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSS------GD 537
                   |:|:   :.::    |...:.:.|.|....||......|::    .::||      ||
Mouse   168 -------GSGL---ILQA----NFVHSQRRESFLYRSDSDYDLSPKSM----SRNSSIASDIHGD 214

  Fly   538 ---VIGVAQVINKM-----NGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDL 594
               |...|||:..:     |....:.:.::..|.....|            :|..|.:..:..:.
Mouse   215 DLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMC------------NQPSINKATITEEA 267

  Fly   595 ARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQIL-LVHEADKGSFSRVFDFEANDLSEEEATSRT 658
            .:.:..|  |:|.:.:       .|.|.:.:|.. .|.|.....|.|:.:.|...|||   .||:
Mouse   268 YQKLASE--TLEELDW-------CLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSE---MSRS 320

  Fly   659 SPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGV 723
            ....|.:     |:.........|.:|:..:.:            |.:.      |..:.||.||
Mouse   321 GNQVSEY-----ISNTFLDKQHEVEIPSPTQKE------------KEKK------KRPMSQISGV 362

  Fly   724 IQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEA 788
            .:|                           :|::.:....|.....::...:||    :..:::.
Mouse   363 KKL---------------------------MHSSSLTNSCIPRFGVKTEQEDVL----AKELEDV 396

  Fly   789 HRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACLR-MFLDLDFVERFHIDYEVLCRWLLSVKK 852
            ::           :.||.|:..::  ..:..|...:. :|.:.|.::.|.|..:.|..:|::::.
Mouse   397 NK-----------WGLHVFRIAEL--SGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 448

  Fly   853 NYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKAS 916
            :|. :|.|||..||.:|.|....:|:|.....:|.::|.||.|.....||:||.|.:|.|.|..:
Mouse   449 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTN 513

  Fly   917 SPLAQLYS-TSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRG 980
            |.||.:|: :|.:|:||......:|......|..||:......:.:::.|.:|:||::.:.....
Mouse   514 SELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLA 578

  Fly   981 PF--LESVSQPTSYWV------AEEPRALLRAMSMTVC-DLSAITKPWEIEKRVADLVSSEFFEQ 1036
            ..  :....:.||..|      ::..:.|   .:|..| |||..|||.::.::..|.:..|||.|
Mouse   579 DLKTMVETKKVTSSGVLLLDNYSDRIQVL---QNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQ 640

  Fly  1037 GDMEKQE-LNITPI-DIMNREKEDELPMMQVNFIDSICLPIYEAFATL-SDKLEPLVEGVRDNRG 1098
            ||.|::. :.|:|: |..|...|..    ||.|||.|..|::|.:|.| ....:.:::.:.|||.
Mouse   641 GDRERERGMEISPMCDKHNASVEKS----QVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNRE 701

  Fly  1099 HWIDLADVVKTKTSQDQEP----EEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDSPSEKASVN 1159
            .:........:....|||.    :.|:.|..:....||                 :|.:||.|
Mouse   702 WYQSTIPQSPSPAPDDQEEGRQGQTEKFQFELTLEEDC-----------------ESDTEKDS-- 747

  Fly  1160 GSNVANNSSNTNKKIAVASHPTSTQ-PSDDDNDVDADADDVDEQAAEENGHDAEVDEASCRSNST 1223
            ||.|..::|.::.|........||: |             :|||..||...:.|....:|..:..
Mouse   748 GSQVEEDTSCSDSKTLCTQDSESTEIP-------------LDEQVEEEAVAEEESQPETCVPDDC 799

  Fly  1224 C 1224
            |
Mouse   800 C 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	34/188 (18%)
		GAF	611..762	CDD:214500	25/151 (17%)
		PDEase_I	859..1093	CDD:459723	73/246 (30%)
Pde4d	NP_001389812.1	PDE4_UCR	218..334	CDD:465648	27/144 (19%)
		PDEase_I	456..696	CDD:459723	73/246 (30%)