DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and Pde6a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_666198.1	Gene:	Pde6a / 225600	MGIID:	97524	Length:	860	Species:	Mus musculus

Alignment Length:	831	Identity:	251/831 - (30%)
Similarity:	433/831 - (52%)	Gaps:	85/831 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 GHQYPYYHCHQRPQRLS--------------RNELKQLDEKELIFELVKDICNELEVRTLCHKIL 428
            |....||:.|.|.:.:|              .:::..::|.|:||:|::|:...|:.......::
Mouse    18 GFAKQYYNFHYRGKVISDLLGAKEAAVDFSNYHDVNSVEESEIIFDLLRDVQENLQAEKCTFNVM 82

  Fly   429 QNVSILLNADRGSLFLVQGRCNGPDGLKKCLVSKLFDVCPRSTVEE--MEQQDEVRVAWGTGIAG 491
            :.:..||.|||.|||:.:.|    :|:.: |.::||:|...:.:|:  :....|:......|:.|
Mouse    83 KKLCFLLRADRMSLFMYRTR----NGIAE-LATRLFNVHKDAVLEDCLVMPDSEIVFPLDMGVVG 142

  Fly   492 HVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEI 556
            |||.|.:..|:|:..:||.|...:|:||.|:||.:|..||.:.. ||:.:...:||::...|::.
Mouse   143 HVAHSKKIANVPNTEEDEHFCDFVDNLTEYQTKNILASPIMNGK-DVVAIIMAVNKIDEPHFTKR 206

  Fly   557 DEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQ 621
            ||::...||.|..:.::...|......|.:|.|:||.....:|||.:.||....:.|..:::.:.
Mouse   207 DEEILLKYLNFVNLIMKVFHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLN 271

  Fly   622 CQRVQI----------------LLVHEADKGS-----------FSRVFDFEANDLSEEEATSRTS 659
            |.|..:                :|:.||...|           |.:|.|:..:  .:|:.....:
Mouse   272 CDRYSVGLLDMTKQKEFFDVWPVLMGEAPAYSGPRTPDGREINFYKVIDYILH--GKEDIKVIPN 334

  Fly   660 PYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVD--ENSCFKHRSILCMAIKNSLGQIIG 722
            |....:.:..|:..:||..|...|:.||..:|.|:...:  :.|.:..:::|.|.|.|...:|:|
Mouse   335 PPADHWALVSGLPTYVAQNGLICNIMNAPAEDFFEFQKEPLDESGWMIKNVLSMPIVNKKEEIVG 399

  Fly   723 VIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDE 787
            |....|:.:...|...||..:|:...|.|..:.|...||.......::.:..:::.||.....:|
Mouse   400 VATFYNRKDGKPFDDMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEE 464

  Fly   788 AHRLRRLR----------------------VPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDL 830
            ..::.:.|                      :|.|..:.::.|.|.|:...:.:.:|..::|:.:|
Mouse   465 IQKILKTREVYGKEPWECEEEELAEILQGELPDAESYEINKFHFSDLPLTELELVKCGIQMYYEL 529

  Fly   831 DFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALII 895
            ..|::|||..|.|.|::.|:.|.||.:|||||||.|||.|.||::|.|.:..:.|.::|.||::.
Mouse   530 RVVDKFHIPQEALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVT 594

  Fly   896 GCLCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVI 960
            ...|||:|||||||.:|:|:.:|||:|:.:|.:|.||.:....:|......|..||:...:...|
Mouse   595 AAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAI 659

  Fly   961 RVLEDAILSTDLAVYFKKRGPF---------LESVSQPTSYWVAEEPR-ALLRAMSMTVCDLSAI 1015
            .:::.||::||||:|||||..|         .||..:.|.|.:.|:.| .::.||.||.||||||
Mouse   660 HMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESTQEWTQYMMLEQTRKEIVMAMMMTACDLSAI 724

  Fly  1016 TKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFA 1080
            |||||::.:||.||::||:||||:|:..|...||.:|:|.|.||||.:||.|||.:|..:|:.|:
Mouse   725 TKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFS 789

  Fly  1081 TLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGD 1131
            ...:::.|:::|:.:||..|..|||..:.|....:|.:::||.....::|:
Mouse   790 RFHEEITPMLDGITNNRKEWKALADEYEAKMKALEEEKQKQQAAKQAASGN 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	47/163 (29%)
		GAF	611..762	CDD:214500	38/179 (21%)
		PDEase_I	859..1094	CDD:278654	107/244 (44%)
Pde6a	NP_666198.1	GAF	67..232	CDD:214500	49/170 (29%)
		GAF	254..441	CDD:214500	41/188 (22%)
		PDEase_I	558..802	CDD:278654	106/243 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750