DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and Pde2a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_006507586.1	Gene:	Pde2a / 207728	MGIID:	2446107	Length:	953	Species:	Mus musculus

Alignment Length:	795	Identity:	254/795 - (31%)
Similarity:	400/795 - (50%)	Gaps:	82/795 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 QRPQRLSRNEL----KQLDEK------ELIFELVKDICNE---LEVRTLCHKILQNVSILLNADR 439
            :||:.:....:    .|.|||      ..|.:|    |.|   |:..:|..|:||.:.....|..
Mouse   213 RRPEAVQNTSVDASEDQKDEKGYTDHDRKILQL----CGELFDLDATSLQLKVLQYLQQETQATH 273

  Fly   440 GSLFLVQGRCNGPDGLK-KCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIP 503
            ..|.||     ..|.|: .|.|           :.:....:||......|..|.|.|..:.:.:.
Mouse   274 CCLLLV-----SEDNLQLSCKV-----------IGDKVLGEEVSFPLTMGRLGQVVEDKQCIQLK 322

  Fly   504 DAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGD-VIGVAQVINKMNGECFSEIDEKVFSSYLQF 567
            |...|:  ..::.::.|...:|:||:|:...:.| |:.:|...||:.|:.|::.||.|......:
Mouse   323 DLTSDD--VQQLQNMLGCELQAMLCVPVISRATDQVVALACAFNKLGGDFFTDEDEHVIQHCFHY 385

  Fly   568 CGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHE 632
            .|..|.:...::|.|......|.||.:|:.:|.....:..::..|:|..::|...:...:.|:.:
Mouse   386 TGTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQ 450

  Fly   633 ADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASV 697
            .:  ..::|||   ..:.::|:      ||.|.|.:.||.|||||||:.:|:|:||....|...|
Mouse   451 NE--LVAKVFD---GGVVDDES------YEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGV 504

  Fly   698 DENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEK 762
            |:::.|:.|:|||..|||...::|||.:|:||.|...|:|.||:...||:|:||:.|.::.:|:|
Mouse   505 DDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKK 569

  Fly   763 AIVAMAKQSVTLEVLSYHASATMDEAHRLRR--LRVPSAVHFRLHDFKFDDIHFEDDDTLKACLR 825
            ...|..:..:..|::.||...:.||..:|..  ::..:|:.....:|.:......:|||..|.|.
Mouse   570 VNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFANFTYTPRSLPEDDTSMAILS 634

  Fly   826 MFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIEC 890
            |..|::|:..:.||...|.|:.|.|||.||:..||||.|||:|:...:.:....:......:||.
Mouse   635 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELSNYLEDIEI 699

  Fly   891 LALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYST--STMEHHHFDQCLMILNSPGNQILANLSS 953
            .||.|.|:||||||||||||||:.:.|.||.|||:  |.||.|||.|.:.|||:.|..|..:.|.
Mouse   700 FALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSR 764

  Fly   954 DDYCRVIRVLEDAILSTDLAVY---FKKRGPFLESVSQPTSYWVAEEPRALLRAMSMTVCDLSAI 1015
            .||.|::.::.|.||:||||.:   ||.    |:.:::........:...||..:.||.||||..
Mouse   765 KDYQRMLDLMRDIILATDLAHHLRIFKD----LQKMAEVGYDRNNRQHHRLLLCLLMTSCDLSDQ 825

  Fly  1016 TKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFA 1080
            ||.|:..:::|:|:..|||.|||:||...| .|:::|:|||. .:|.:|::|::.|.:|||:...
Mouse   826 TKGWKTTRKIAELIYKEFFSQGDLEKAMGN-RPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQ 888

  Fly  1081 TLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCKAMSDDDVAASEA 1145
            .|..|...|.|.|..||.||        ||.|      .:...:.:.||...      |....|.
Mouse   889 DLFPKAAELYERVASNREHW--------TKVS------HKFTIRGLPSNNSL------DFLDEEY 933

  Fly  1146 EVAVDSPSEKASVNG 1160
            ||. |....:|.|||
Mouse   934 EVP-DLDGTRAPVNG 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	38/163 (23%)
		GAF	611..762	CDD:214500	54/150 (36%)
		PDEase_I	859..1094	CDD:278654	98/239 (41%)
Pde2a	XP_006507586.1	GAF	253..400	CDD:214500	38/164 (23%)
		GAF	422..571	CDD:214500	55/159 (35%)
		PDEase_I	668..901	CDD:365964	98/238 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844394
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750