Protein Alignment Pde11 and pde-6

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001370828.1
• Gene: pde-6 / 190808
• WormBaseID: WBGene00022389
• Length: 760
• Species: Caenorhabditis elegans
• Alignment Length: 907
• Identity: 194/907 - (21%)
• Similarity: 343/907 - (37%)
• Gaps: 252/907 - (27%)

  Fly   299 DNGSVGGSCSNLQNVGGVVAGQYQYNHQQHHHNHAHLHHSQHSHYQAGGAVGSSS---------- 353
            |...|||. ...::|.|..|      |.|......|...::....:|..|..:::
 Worm     3 DRSGVGGE-EGEKSVLGASA------HSQAGRRQQHTPAARRGAQRAPAATAAAASRPVFAMRWC 60

  Fly   354 LGSTGGASGAGGAPSLGGSGGAGNGHQYPYYHCHQRPQRLSRNELKQLDEKELIFELVKDICNEL 418
            .|.:...:|.||    |||.||             .|..|       |...........|....:
 Worm    61 CGGSYSENGGGG----GGSRGA-------------PPTPL-------LTVAATSSSTAHDTFGPM 101

  Fly   419 EVRTLCHKIL----QNVSILLNADRGSLFLVQGRCNGPDGLKKCLV-------SKLFDVCPRSTV 472
            :|:.|...::    ...|:||::.|.|.::             |.|       |.:..:||.:..
 Worm   102 QVKMLKTAVIVTEGTGESVLLDSLRASGWI-------------CTVSFPTQATSDVESICPLAVF 153

  Fly   473 EEMEQQDEVRVAWGTGIAGHVAE-SGEP---VNIPDAYQDERFNCEIDSLTGYRTKAL----LCM 529
            .::      ||...:.||..|:. |.|.   |:|.:.:..|:           |.:||    :..
 Worm   154 IDL------RVPHPSQIAKDVSSVSTEEVLIVSIAEKHISEK-----------RRRALAQSNIIH 201

  Fly   530 PIKDSSGDVI---GVAQVINKMNG--ECFSEIDEKVFSSYLQFCG---------------IGLRN 574
            .:..::.||:   .|.::.|::..  ..|:.:||.  ...::.|.               .|...
 Worm   202 HVTWNTRDVVLFDYVGRLANRIRALPALFAVLDET--DQAVEICDEQRVVQYVNRAYENVTGCIR 264

  Fly   575 AQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRI-LTHMQSLIQCQRVQILLVHEADKGSF 638
            :::..:.:.|::|..  |..||...|.:.:.:....|: ..:....:..:|       ....|..
 Worm   265 SEVIGQPESEMRRKS--LPRARGEEERRRSCDWKFIRVPFANNSQFVYMKR-------SNTTGDT 320

  Fly   639 SRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDENSCF 703
            :.:|    .|:|.:...|:|...|:  ||:     .|.|....|:           |.||...
 Worm   321 AAIF----RDVSLKSLKSQTGGIEA--PIS-----EVLTMLRDVS-----------ARVDGEP-- 361

  Fly   704 KHRSILCMAIKNSLGQIIGVIQL----INKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAI 764
                  ...||::: :::...:|    ||:|.:.|...                   |..|:..|
 Worm   362 ------AQTIKDAM-KVLSSHELYAPSINRFRDADRIA-------------------TQYYDGLI 400

  Fly   765 -----VAMAKQSVTLEVLSYHASATMDEAHRLR------RLRVPSAVHFRLHD---FKFDDIHFE 815
                 ....|:||.             :|||.:      |.||.:.|...|.:   :|||.:|.|
 Worm   401 RLHHPARQRKRSVV-------------DAHREKRGSHGERRRVSADVKNALENDNCWKFDILHLE 452

  Fly   816 ---DDDTL-KACLRMFLDLDFVERFHI------DYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVA 869
               |...| :..:::|      ||:.:      ..::|.||:||::.:|. ..||||..||.:|.
 Worm   453 KVSDHHALSQVGMKVF------ERWKVCDVLGCSDDLLHRWILSIEAHYHAGNTYHNATHAADVL 511

  Fly   870 QMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHF 933
            |.....|.:........|...:|.::....|||||.|..|::.|.....||.||: .|.:|:||.
 Worm   512 QATSFFLDSPSVAVHVNESHAVAALLAAAVHDLDHPGRGNAYLINTRQSLAILYNDNSILENHHI 576

  Fly   934 DQC--LMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAE 996
            ...  |.:.::....|.::||.:::.::...:.:.:|:||::.:|       |.:::.....|.:
 Worm   577 ALAFQLTLQHNANVNIFSSLSREEFIQMRHAMVEMVLATDISRHF-------EYLAKFNKMHVTD 634

  Fly   997 EPRALLRAMSMTVCDL----SAITKP---WEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMN 1053
            .|.......|:|:||:    :.|:.|   |.:.:|.|..:..|:|||...||:: |.:| :::.:
 Worm   635 VPEEQRDTNSLTICDMLVKCADISNPAREWGLCQRWAHRIVEEYFEQTREEKEKGLPVT-MEVFD 698

  Fly  1054 REKEDELPMMQVNFIDSICLPIYEAFATLSD--KLEPLVEGVRDNRGHWIDLADVVKTKTSQ 1113
            | ....:|:.|..|||...   .|||||.::  ||..|.:.:..|...|       |..|||
 Worm   699 R-NTCNVPITQCGFIDMFA---REAFATFTEFAKLGELSDQLESNYEKW-------KVMTSQ 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	34/200 (17%)
		GAF	611..762	CDD:214500	26/155 (17%)
		PDEase_I	859..1094	CDD:278654	68/247 (28%)
pde-6	NP_001370828.1	PDEase_I	501..737	CDD:395177	68/247 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920